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Human papillomavirus in Ethiopia

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Abstract

Over 99% of cervical cancer cases are associated with genital infection by certain types of human papillomaviruses (HPVs). To outline optimal vaccination strategies and HPV based cervical cancer screening, synthesized data on the genotype distribution of HPV is fundamental that is otherwise missed in Ethiopia. The aim of this study is to compile the findings on HPV genotyping in Ethiopia. Published articles were systematically searched using comprehensive search strings from PubMed/Medline and SCOPUS. Further, Google Scholar and the Google databases were also searched manually for grey literature. The included studies in the review employed 859 women (age range 15–85 years) with different kinds of cervical abnormalities. A total of 534 HPV sequences were reported; the proportion of high risk HPVs was varied 80.4–100%. The top five identified genotypes were HPV 16 (45.3%; 95% CI 41.1–49.6%), HPV 52 (9.4%; 95% CI 7.2–12.1%), HPV 18 (8.2%; 95% CI 6.2–10.9%), HPV 58 (6.9%; 95% CI 5.1–9.4%) and HPV 45 (5.2%; 95% CI 3.7–7.5%). The combined prevalence of HPV 16/18 was at 53.6% (95% CI 49.3–57.8%). In this review, HPV 16 in particular, but also HPV 52 and 18, warrant exceptional consideration in vaccination and HPV based screening programs in Ethiopia. To the best of our knowledge, this study represents the first of its kind to establish the genotype distribution of HPV from different kinds of cervical lesions in Ethiopia although it was synthesized out of few studies. Hence, additional nationwide data are needed to strengthen our finding.

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References

  1. Abate E, Aseffa A, El-Tayeb M, El-Hassan I, Yamuah L, Mihret W, et al. Genotyping of human papillomavirus in paraffin embedded cervical tissue samples from women in Ethiopia and the Sudan. J Med Virol. 2013;85(2):282–7. https://doi.org/10.1002/jmv.23437.

    Article  PubMed  Google Scholar 

  2. Bansal D, Elmi AA, Skariah S, Haddad P, Abu-Raddad LJ, Al Hamadi AH, et al. Molecular epidemiology and genotype distribution of human papillomavirus (HPV) among Arab women in the State of Qatar. J Transl Med. 2014;12(300):014–0300.

    Google Scholar 

  3. Bekele A, Baay M, Mekonnen Z, Suleman S, Chatterjee S. Human papillomavirus type distribution among women with cervical pathology—a study over 4 years at Jimma Hospital, southwest Ethiopia. Trop Med Int Health. 2010;15(8):890–3.

    Article  CAS  PubMed  Google Scholar 

  4. Bekele A, Baay M, Mekonnen Z, Suleman S, Chatterjee S. Human papillomavirus type distribution among women with cervical pathology—a study over 4 years at Jimma Hospital, southwest Ethiopia. Trop Med Int Health. 2010;15(8):890–3. https://doi.org/10.1111/j.1365-3156.2010.02552.x.

    Article  CAS  PubMed  Google Scholar 

  5. Bi Q, Zhang L, Zhao Z, Mu X, Zhang M, Wang P. Human papillomavirus prevalence and genotypes distribution among female outpatients in Qingdao, East China. J Med Virol. 2015;87(12):2114–21.

    Article  PubMed  Google Scholar 

  6. Bradford L, Goodman A. Cervical cancer screening and prevention in low-resource settings. Clin Obstet Gynecol. 2013;56(1):76–87.

    Article  PubMed  Google Scholar 

  7. Bruni L, Diaz M, Castellsague X, Ferrer E, Bosch FX, de Sanjose S. Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis. 2010;202(12):1789–99.

    Article  PubMed  Google Scholar 

  8. Chan PK, Li WH, Chan MY, Ma WL, Cheung JL, Cheng AF. High prevalence of human papillomavirus type 58 in Chinese women with cervical cancer and precancerous lesions. J Med Virol. 1999;59(2):232–8.

    Article  CAS  PubMed  Google Scholar 

  9. Chen X, Wallin KL, Duan M, Gharizadeh B, Zheng B, Qu P. Prevalence and genotype distribution of cervical human papillomavirus (HPV) among women in urban Tianjin, China. J Med Virol. 2015;87(11):1966–72.

    Article  CAS  PubMed  Google Scholar 

  10. Ciapponi A, Bardach A, Glujovsky D, Gibbons L, Picconi MA. Type-specific HPV prevalence in cervical cancer and high-grade lesions in Latin America and the Caribbean: systematic review and meta-analysis. PLoS ONE. 2011;6(10):4.

    Article  CAS  Google Scholar 

  11. Clifford GM, Rana RK, Franceschi S, Smith JS, Gough G, Pimenta JM. Human papillomavirus genotype distribution in low-grade cervical lesions: comparison by geographic region and with cervical cancer. Cancer Epidemiol Biomark Prev. 2005;14(5):1157–64.

    Article  Google Scholar 

  12. de Sanjose S, Diaz M, Castellsague X, Clifford G, Bruni L, Munoz N, et al. Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis. 2007;7(7):453–9.

    Article  PubMed  Google Scholar 

  13. Doorbar J, Quint W, Banks L, Bravo IG, Stoler M, Broker TR, et al. The biology and life-cycle of human papillomaviruses. Vaccine. 2012;20(30):083.

    Google Scholar 

  14. Elmi AA, Bansal D, Acharya A, Skariah S, Dargham SR, Abu-Raddad LJ, et al. Human papillomavirus (HPV) Infection: molecular epidemiology, genotyping, seroprevalence and associated risk factors among Arab women in Qatar. PLoS ONE. 2017;12(1):e0169197.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Forman D, de Martel C, Lacey CJ, Soerjomataram I, Lortet-Tieulent J, Bruni L, et al. Global burden of human papillomavirus and related diseases. Vaccine. 2012;20(30):055.

    Google Scholar 

  16. Giorgi Rossi P, Chini F, Borgia P, Guasticchi G, Carozzi FM, Confortini M, et al. Human papilloma virus (HPV), cervical cancer incidence and screening uptake: differences among Northern, Central and Southern Italy. Epidemiol Prev. 2012;36(2):108–19.

    PubMed  Google Scholar 

  17. Guan P, Howell-Jones R, Li N, Bruni L, de Sanjose S, Franceschi S, et al. Human papillomavirus types in 115,789 HPV-positive women: a meta-analysis from cervical infection to cancer. Int J Cancer. 2012;131(10):2349–59.

    Article  CAS  PubMed  Google Scholar 

  18. Kietpeerakool C, Kleebkaow P, Srisomboon J. Human papillomavirus genotype distribution among Thai women with high-grade cervical intraepithelial lesions and invasive cervical cancer: a literature review. Asian Pac J Cancer Prev. 2015;16(13):5153–8.

    Article  PubMed  Google Scholar 

  19. Leyh-Bannurah S-R, Prugger C, de Koning MNC, Goette H, Lellé RJ. Cervical human papillomavirus prevalence and genotype distribution among hybrid capture 2 positive women 15 to 64 years of age in the Gurage zone, rural Ethiopia. Infect Agents Cancer. 2014;9:33. https://doi.org/10.1186/1750-9378-9-33.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Louie KS, de Sanjose S, Mayaud P. Epidemiology and prevention of human papillomavirus and cervical cancer in sub-Saharan Africa: a comprehensive review. Trop Med Int Health. 2009;14(10):1287–302.

    Article  PubMed  Google Scholar 

  21. Maine D, Hurlburt S, Greeson D. Cervical cancer prevention in the 21st century: cost is not the only issue. Am J Public Health. 2011;101(9):1549–55. https://doi.org/10.2105/AJPH.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Malary M, Moosazadeh M, Hamzehgardeshi Z, Afshari M, Moghaddasifar I, Afsharimoghaddam A. The prevalence of cervical human papillomavirus infection and the most at-risk genotypes among Iranian healthy women: a systematic review and meta-analysis. Int J Prev Med. 2016;7(70):2008–7802.

    Google Scholar 

  23. Maria H, Dana H, Francoise M, Michael P, Jurgen W. Human papillomaviruses in Western Africa: prevalences and risk factors in Burkina Faso. Arch Gynecol Obstet. 2018;17(10):018–4860.

    Google Scholar 

  24. Mihret W, Yusuf L, Abebe M, Yamuah LK, Bekele L, Abate E, et al. A pilot study on detection and genotyping of human papilloma virus isolated from clinically diagnosed Ethiopian women having cervical intraepithelial neoplasia. Ethiop Med J. 2014;1:49–52.

    PubMed  Google Scholar 

  25. Münger K, Baldwin A, Edwards KM, Hayakawa H, Nguyen CL, Owens M, et al. Mechanisms of human papillomavirus-induced oncogenesis. J Virol. 2004;78(21):11451–60. https://doi.org/10.1128/jvi.78.21.11451-11460.2004.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Ogembo RK, Gona PN, Seymour AJ, Park HS, Bain PA, Maranda L, et al. Prevalence of human papillomavirus genotypes among African women with normal cervical cytology and neoplasia: a systematic review and meta-analysis. PLoS ONE. 2015;10(4):e0122488.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Peng RR, Li HM, Chang H, Li JH, Wang AL, Chen XS. Prevalence and genotype distribution of cervical human papillomavirus infection among female sex workers in Asia: a systematic literature review and meta-analysis. Sex Health. 2012;9(2):113–9.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Poljak M, Seme K, Maver PJ, Kocjan BJ, Cuschieri KS, Rogovskaya SI, et al. Human papillomavirus prevalence and type-distribution, cervical cancer screening practices and current status of vaccination implementation in Central and Eastern Europe. Vaccine. 2013;31(31):029.

    Google Scholar 

  29. Sankaranarayanan R, Bhatla N, Gravitt PE, Basu P, Esmy PO, Ashrafunnessa KS, et al. Human papillomavirus infection and cervical cancer prevention in India, Bangladesh, Sri Lanka and Nepal. Vaccine. 2008;19(26):005.

    Google Scholar 

  30. Shamseer L, Moher D, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation. BMJ. 2015;350:g7647.

    Article  PubMed  Google Scholar 

  31. Shavit O, Roura E, Barchana M, Diaz M, Bornstein J. Burden of human papillomavirus infection and related diseases in Israel. Vaccine. 2013;22(31):108.

    Google Scholar 

  32. Singh S, Zhou Q, Yu Y, Xu X, Huang X, Zhao J, et al. Distribution of HPV genotypes in Shanghai women. Int J Clin Exp Pathol. 2015;8(9):11901–8.

    PubMed  PubMed Central  Google Scholar 

  33. Smith JS, Melendy A, Rana RK, Pimenta JM. Age-specific prevalence of infection with human papillomavirus in females: a global review. J Adolesc Health. 2008;43(4 Suppl):009.

    Google Scholar 

  34. Ting J, Kruzikas DT, Smith JS. A global review of age-specific and overall prevalence of cervical lesions. Int J Gynecol Cancer. 2010;20(7):1244–9.

    Article  PubMed  Google Scholar 

  35. Zhai L, Tumban E. Gardasil-9: a global survey of projected efficacy. Antivir Res. 2016;130:101–9.

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

Authors are delighted to thank Bahir Dar and Addis Ababa Universities and CDT-Africa for the opportunity we have provided to conduct this review article.

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Authors and Affiliations

  1. Department of Medical Microbiology, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia

    Awoke Derbie, Daniel Mekonnen & Fantahun Biadglegne

  2. Centre for Innovative Drug Development and Therapeutic Trials for Africa (CDT-Africa), Addis Ababa University, Addis Ababa, Ethiopia

    Awoke Derbie

  3. Department of Health Biotechnology, Biotechnology Research Institute, Bahir Dar University, Bahir Dar, Ethiopia

    Daniel Mekonnen

  4. Amhara Public Health Institute (APHI), Bahir Dar, Ethiopia

    Gizachew Yismaw

  5. Laboratory of Protein Science, Proteomics and Epigenetic Signaling (PPES), Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

    Xaveer Van Ostade

  6. Department of Medical Microbiology, Immunology and Parasitology, School of Medicine, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia

    Tamrat Abebe

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  1. Awoke Derbie
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Correspondence to Awoke Derbie.

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Derbie, A., Mekonnen, D., Yismaw, G. et al. Human papillomavirus in Ethiopia. VirusDis. 30, 171–179 (2019). https://doi.org/10.1007/s13337-019-00527-4

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