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Health related quality of life in Indian children with cystic fibrosis

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Abstract

Objective

This study was devised to translate Cystic Fibrosis Questionnaire-Revised to Hindi and administer it to Indian children and adolescents diagnosed with cystic fibrosis.

Design

Cross-sectional study.

Setting

This study was carried out in cystic fibrosis patients attending Pediatric Chest Clinic of a tertiary-care hospital in Northern India from July 2012 to December 2012.

Participants

45 children (6–13 years) and their parents, and 14 adolescents. Patients with unstable health in the past two weeks were excluded.

Intervention

Cystic Fibrosis Questionnaire- Revised translated in Hindi was administered. Clinical evaluation and scoring, throat swab cultures and spirometry were also done during the same visit.

Main Outcome Measures

Health Related Quality of Life scores were the primary measures, and clinical scores, swab cultures and spirometry were secondary measures.

Results

Cronbach’s alpha ranged from 0.020–0.863.The Factor analysis indicated that most test-items correlated more with competing scales than the intended scales. Convergence between self and proxy-rating was found to be dependent on the domain. The Cystic Fibrosis Questionnaire-Revised scores correlated well with clinical scores (r=0.65,P=0.011), Pseudomonas spp culture data and pulmonary function tests. There was an inverse relation between Health Related Quality of Life scores and age at diagnosis (r=-0.339, P=0.02).

Conclusions

Hindi versions of Cystic Fibrosis Questionnaire- Revised: Child, Adolescent and Parents’ instruments will act as an important step towards data on Health Related Quality of Life of Indian patients with cystic fibrosis.

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Authors and Affiliations

  1. Departments of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110 029, India

    Devika Kir, Sumita Gupta, George Jolly, Rakesh Lodha & S. K. Kabra

  2. Departments of Biostatistics, All India Institute of Medical Sciences, New Delhi, India

    M. Kalaivani

Authors
  1. Devika Kir
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  2. Sumita Gupta
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  3. George Jolly
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  4. M. Kalaivani
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  5. Rakesh Lodha
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  6. S. K. Kabra
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Corresponding author

Correspondence to S. K. Kabra.

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Kir, D., Gupta, S., Jolly, G. et al. Health related quality of life in Indian children with cystic fibrosis. Indian Pediatr 52, 403–408 (2015). https://doi.org/10.1007/s13312-015-0645-7

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  • DOI: https://doi.org/10.1007/s13312-015-0645-7

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