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Immunoglobulin levels and CD4 / CD8 counts in β — Thalassemia major

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Abstract

Objective

This cross-sectional study determined the CD4, CD8 counts and serum immunoglobulins in transfusion dependent β-thalassemic patients, and correlated them with anti-HIV, anti-HCV and HBsAg status, number of transfusions, iron overload and splenectomy.

Methods

Patients with acute or chronic diseases (except HIV, Hepatitis B and C), on immunosuppressive drugs or vaccinated within one month prior to study were excluded. CD4, CD8 counts and serum Immunoglobulins were documented.

Results

Increasing transfusions led to higher IgA and IgM as well as a decline in CD4 and CD8 levels. Higher ferritin correlated with high IgM. CD4, CD8 and IgA were significantly higher in splenectomized subjects. HCV correlated significantly with lower IgA values.

Conclusion

Higher transfusion requirement, iron overload, splenectomy and HCV infection correlated with alterations in different immunological parameters.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Pediatric Hematology-Oncology, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai, 400 022, India

    P. P. Kadam, M. V. Manglani, S. M. Sharma, R. A. Sharma & M. S. Setia

Authors
  1. P. P. Kadam
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  2. M. V. Manglani
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  3. S. M. Sharma
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  4. R. A. Sharma
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  5. M. S. Setia
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Correspondence to M. V. Manglani.

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Kadam, P.P., Manglani, M.V., Sharma, S.M. et al. Immunoglobulin levels and CD4 / CD8 counts in β — Thalassemia major. Indian Pediatr 51, 1000–1002 (2014). https://doi.org/10.1007/s13312-014-0546-1

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  • DOI: https://doi.org/10.1007/s13312-014-0546-1

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