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Cytoreductive surgery followed by HIPEC repetition for secondary ovarian cancer recurrence

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Abstract

Secondary and tertiary cytoreductive surgery was associated with improved overall survival in platinum-sensitive recurrent ovarian cancer (ROC). Hyperthermic intraoperative intra-peritoneal chemotherapy (HIPEC) is considered an attractive method in the treatment of ROC to deliver chemotherapy with enhanced effect directly at the tumor site. However, another deserving aspect is the feasibility and the oncologic role of HIPEC repetition. Twelve patients affected by secondary ovarian cancer recurrence previously submitted to cytoreduction followed by HIPEC were enrolled for the present study to receive tertiary cytoreduction followed by HIPEC repetition. The median operative time, including time for HIPEC procedure, was 360 min (range 240–540). Average EBL was 325 ml (from 100 to 500 ml). The median hospital stay was of 5 days, from 4 to 10. Low-grade post operatory complications occurred in 2 patients (16.6%) and high-grade complication in 1 case (8.3%). Our study report encouraging data about safety of HIPEC repetition in ovarian cancer treatment.

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The work was not supported by any fund/Grant.

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Authors and Affiliations

  1. Unità Operativa Ginecologia Oncologica, Dipartimento Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Univeristario A. Gemelli, IRCCS, Rome, Italy

    Stefano Cianci & Giuseppe Vizzielli

  2. Department of Medicine and Aging Sciences, University “G. D’Annunzio” of Chieti-Pescara, Chieti, Italy

    Carlo Ronsini

  3. Department for the Treatment and Study of Abdominal Diseases and Abdominal Transplantation, IRCCS-ISMETT, (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), University of Pittsburgh Medical Center Italy, Palermo, Italy

    Alessandro Tropea

  4. Department of General Surgery and Medical Surgical Specialties, University of Catania, Catania, Italy

    Antonio Biondi

  5. Unità Operativa Ginecologia Oncologica, Dipartimento Scienze della Salute della Donna e del Bambino, Fondazione Policlinico Univeristario A. Gemelli, IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy

    Giovanni Scambia & Anna Fagotti

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  1. Stefano Cianci
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  2. Carlo Ronsini
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  3. Giuseppe Vizzielli
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  7. Anna Fagotti
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Correspondence to Stefano Cianci.

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Cianci, S., Ronsini, C., Vizzielli, G. et al. Cytoreductive surgery followed by HIPEC repetition for secondary ovarian cancer recurrence. Updates Surg 71, 389–394 (2019). https://doi.org/10.1007/s13304-018-0600-y

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