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GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis

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Tumor Biology

Abstract

GSTM1 gene encodes a key enzyme involved in the metabolism of xenobiotics, and its polymorphisms have been related to individual susceptibility to several malignancies. Many molecular epidemiological studies were performed to investigate the association between the GSTM1 null polymorphism and lung cancer susceptibility in East Asia. However, the results were inconsistent. In order to derive a more precise estimation, we conducted this meta-analysis involving 5,909 lung cancer cases and 7,067 controls from 35 studies. We used crude odds ratios (ORs) with 95 % confidence intervals (CIs) to assess the association between GSTM1 null genotype and the risk of lung cancer. Our study found that the GSTM1 null genotype appeared to be a significant risk factor for lung cancer in East Asia population (OR = 1.30, 95 % CI = 1.17–1.45, P heterogeneity < 0.0001, and I 2 = 54.0 %).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 450001, Zhengzhou, China

    Yan Zhao & Yanxi Zhang

  2. Henan Tumor Hospital, Affiliated Tumor Hospital of Zhengzhou University, 450003, Zhengzhou, China

    Yan Zhao, Junjie Zeng, Yanxi Zhang & Erjiang Zhao

  3. Tianjin Medical University Cancer Institute and Hospital, Tianjin, 30006, China

    Su Lu

  4. Department of Epidemiology, Henan Tumor Institute, 450003, Zhengzhou, China

    Ziming Huang & Weiquan Lu

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  1. Yan Zhao
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  2. Junjie Zeng
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Correspondence to Weiquan Lu.

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Yan Zhao and Junjie Zeng equally contribute to this work.

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Zhao, Y., Zeng, J., Zhang, Y. et al. GSTM1 polymorphism and lung cancer risk among East Asian populations: a meta-analysis. Tumor Biol. 35, 6493–6500 (2014). https://doi.org/10.1007/s13277-014-1832-1

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