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HDAC5 promotes osteosarcoma progression by upregulation of Twist 1 expression

  • Research Article
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Tumor Biology

Abstract

Histone deacetylases (HDACs) form a family of enzymes, which have fundamental roles in the epigenetic regulation of gene expression and contribute to the growth, differentiation, and apoptosis of cancer cells. In this study, we firstly investigated the biological function of HDAC5 in osteosarcoma cells. We found that mRNA and protein levels of HDAC5 were upregulated in osteosarcoma tissues and cell lines. Furthermore, overexpression of HDAC5 could promote cell proliferation in osteosarcoma cell lines. In contrast, HDAC5 knockdown using small interfering RNA inhibited cell proliferation. At the molecular level, we demonstrated that HDAC5 promoted mRNA expression of twist 1, which has been reported as an oncogene. Together, these results highlighted for the first time an unrecognized link between HDAC5 and osteosarcoma progression and demonstrated that its specific inhibition might contribute to the treatment of tumorigenesis.

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Acknowledgement

We thank Dr. Bin Qiao for his critical reading this manuscript and useful suggestions.

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Authors and Affiliations

  1. Department of Orthopedic, Huashan Hospital, Fudan University, Shanghai, 200040, China

    Jie Chen, Jun Xia, Yong-lin Yu, Si-qun Wang, Yi-bing Wei, Fei-yan Chen, Gang-yong Huang & Jing-sheng Shi

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  1. Jie Chen
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  2. Jun Xia
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  3. Yong-lin Yu
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  8. Jing-sheng Shi
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Correspondence to Jun Xia.

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Chen, J., Xia, J., Yu, Yl. et al. HDAC5 promotes osteosarcoma progression by upregulation of Twist 1 expression. Tumor Biol. 35, 1383–1387 (2014). https://doi.org/10.1007/s13277-013-1189-x

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  • DOI: https://doi.org/10.1007/s13277-013-1189-x

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