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Influence of spill-over for 99mTc images and the effect of scatter correction for dual-isotope simultaneous acquisition with 99mTc and 18F using small-animal SPECT-PET/CT system

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Abstract

A dual-isotope simultaneous acquisition (DISA) of 99mTc and 18F affects the image quality of 99mTc by crosstalk and spill-over from 18F. We demonstrated the influence of spill-over and crosstalk on image quality and its correction effect for DISA SPECT with 99mTc and 18F. A fillable cylindrical chamber of 30 mm with NEMA-NU4 image quality phantom was filled with 99mTc only or a mixed 99mTc and 18F solution (C100). Two small-region chambers were filled with 99mTc only or a mixed 99mTc and 18F solution made at half the radioactivity concentration of C100 (C50) and non-radioactive water (C0). The 18F/99mTc ratio for DISA was set at approximately 0.4–12. Two types of 99mTc transverse images with and without scatter correction (SC and nonSC) were created. The 99mTc images of single-isotope acquisition (SIA) were created as a reference. The DISA/SIA ratio and contrast of 99mTc were compared between SIA and DISA. Although the DISA/SIA ratios with nonSC of C100, C50 and C0 gradually increased with increasing 18F/99mTc ratio, it was nearly constant by SC. The contrasts of C100 and C50 were similar to a reference value for both nonSC and SC. In conclusion, DISA images showed lower image quality as the 18F/99mTc ratio increased. The image quality in hot-spot regions such as C100 and C50 was improved by SC, whereas cold-spot regions such as C0 could not completely remove the influence of spill-over even with SC.

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Data Availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

This study was supported by JSPS KAKENHI Grant-in-Aid for Early-Career Scientists Number 18K15628.

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Authors and Affiliations

  1. Department of Quantum Medical Technology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan

    Takayuki Shibutani & Masahisa Onoguchi

  2. Department of Quantum Medical Technology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan

    Takayuki Shibutani, Masahisa Onoguchi & Takayuki Kanno

  3. Department of Radiological Technology, Nagoya University Hospital, Nagoya, Japan

    Takayuki Kanno

  4. Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

    Takayuki Kanno

  5. Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan

    Seigo Kinuya

Authors
  1. Takayuki Shibutani
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  2. Masahisa Onoguchi
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  3. Takayuki Kanno
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  4. Seigo Kinuya
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Contributions

All authors contributed to the study’s conception and design. Study design and data collection were performed by TS, TK and MO. Data analysis was performed by and TS and TK. This study was supervised by MO. Radiopharmaceuticals were prepared by SK. The first draft of the manuscript was written by TS, and all authors commented on the previous version of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Masahisa Onoguchi.

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The authors report no potential conflicts of interest relevant to this study.

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This study is a physical evaluation of a phantom experiment. Therefore, this study does not require Ethical approval.

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Shibutani, T., Onoguchi, M., Kanno, T. et al. Influence of spill-over for 99mTc images and the effect of scatter correction for dual-isotope simultaneous acquisition with 99mTc and 18F using small-animal SPECT-PET/CT system. Phys Eng Sci Med 47, 135–142 (2024). https://doi.org/10.1007/s13246-023-01348-y

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  • DOI: https://doi.org/10.1007/s13246-023-01348-y

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