Abstract
Chalcones are hydrophobic polyphenols with extremely poor aqueous solubility. In this study, we prepared a new chalcone derivative-loaded nanoparticle (DPP-23-loaded NP) using a monomethoxy poly(ethylene glycol)-poly(D,L-lactide) copolymer which, in an aqueous environment, spontaneously forms a micellar formation with an average particle size of 20.8 nm. Exposure to various concentrations of DPP-23-loaded NP significantly diminished the cell viability of MCF-7 and MDA-MB-231 cells in a concentration-dependent manner. Our data show that DPP-23-loaded NP is a reliable drug delivery system, as observed by the fluorescein isothiocyanate (FITC) intensity accumulation in MDA-MB-231 cells.
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Acknowledgment: This research was supported by the academic research fund of Hoseo University in 2014 (2014-0454).
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Kim, Y.J., Lee, K.P., Lee, D.Y. et al. Anticancer Activity of a New Chalcone Derivative-Loaded Polymeric Micelle. Macromol. Res. 27, 48–54 (2019). https://doi.org/10.1007/s13233-019-7002-y
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DOI: https://doi.org/10.1007/s13233-019-7002-y