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Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs

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Abstract

Polylactide (PLA) electrospun microfibers were prepared and loaded with triclosan (TCS), ketoprofen (KTP), or their combination to obtain multifunctional scaffolds with bactericide and anti-inflammatory properties. Continuous and porous fibers with diameters in the micrometer scale and a unimodal distribution were successfully attained using a dual-electrospinning technique. Dual drug-loaded scaffolds showed a peculiar release that was in contrast to the single drug-loaded systems, which suggested the establishment of intermolecular interactions that delayed TCS and KTP release. Antimicrobial activity of all TCS-loaded electrospun scaffolds was demonstrated against E. coli and M. luteus bacteria; and furthermore, KTP-loaded samples slightly showed bactericide activity. Biocompatibility of scaffolds was evaluated by adhesion and proliferation assays, and interestingly, the dual drug-load systems were able to support high TCS doses without adverse effects.

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Authors and Affiliations

  1. Departament d’Enginyeria Química, Universitat Politècnica de Catalunya, Av. Diagonal 647, Barcelona, E-08028, Spain

    Elena Llorens, Luis J. del Valle & Jordi Puiggalí

  2. Center for Research in Nano-Engineering (CrNE), Universitat Politècnica de Catalunya, Edifici C, C/Pasqual i Vila s/n, Barcelona, E-08028, Spain

    Luis J. del Valle & Jordi Puiggalí

Authors
  1. Elena Llorens
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  2. Luis J. del Valle
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  3. Jordi Puiggalí
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Correspondence to Luis J. del Valle.

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Llorens, E., del Valle, L.J. & Puiggalí, J. Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs. Macromol. Res. 23, 636–648 (2015). https://doi.org/10.1007/s13233-015-3082-5

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