Abstract
Introduction
Gestational diabetes mellitus is one of the most common conditions complicating pregnancy. Vitamin D deficiency is closely associated with gestational diabetes mellitus.
Objectives
To study the effect of vitamin D supplementation on diabetic pregnant women with vitamin D deficiency.
Methods
This randomized controlled study was conducted with 100 diabetic pregnant women. They were randomized into group A and group B. Group A were screened for vitamin D deficiency once diagnosed with GDM of which 40 were found to be deficient and allotted to group D (n = 40) and were supplemented with 60,000 units of vitamin D3 per month. Group B were given routine antenatal care and were screened for vitamin D deficiency when they were admitted for delivery, and 39 of them were found to have vitamin D deficiency and were studied as control group C (n = 39). Ten women in both the groups had normal levels of vitamin D, and one of them was excluded from the study as she had molar pregnancy. The vitamin D supplemented group D and the control group C were matched for age and parity at the baseline.
Results
There was a significant increase in the mean insulin and metformin requirements in both the supplemented and control groups. Vitamin D supplementation did not improve the glycaemic control in diabetic pregnant women.
Conclusion
Vitamin D supplementation did not decrease insulin resistance or improve the glycaemic control in diabetic pregnant women with vitamin D deficiency.
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The authors declare that they have no conflict of interest.
Ethical Approval
An ethical clearance was obtained from Bangalore Baptist Hospital Institutional Review Board on 19 February 2015.
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A written informed consent was taken from all the participants. Subjects participated voluntarily with full right to withdraw from the study at any point of time.
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R. V. Bhavya Swetha (MBBS, DNB(OBGY)) is currently working as Registrar in the Department of Obstetrics and Gynaecology, Omni RK Hospital, Vishakhapatnam. Rajnish Samal is a Senior Consultant in Department of OBGY, Bangalore Baptist Hospital, Karnataka, India. Carolin Elizabeth George is a HOD in Department of Community Medicine, Bangalore Baptist Hospital, Karnataka, India.
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Bhavya Swetha, R.V., Samal, R. & George, C.E. The Effect of Vitamin D Supplementation on Improving Glycaemic Control in Diabetic Vitamin D-Deficient Pregnant Women: A Single-Blinded Randomized Control Trial. J Obstet Gynecol India 70, 119–125 (2020). https://doi.org/10.1007/s13224-019-01289-1
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DOI: https://doi.org/10.1007/s13224-019-01289-1