Abstract
Objectives
This study was done to compare isoxpurine hydrochloride and nifedipine as tocolytic drugs for preterm labor.
Methods
A prospective cohort study of 832 antenatal women with preterm labor was conducted in the Department of Obstetrics & Gynecology. Out of 400 women found eligible for tocolysis, 200 were given isoxpurine hydrochloride while the other 200 were given nifedipine randomly. The data obtained was statistically analyzed on SPSS 10.0 of Windows 2003.
Results
Incidence of preterm labor was 22% while the incidence of preterm delivery was 20.9%. Nifedipine was twice more effective than isoxpurine hydrochloride as a tocolytic agent as a tocolytic agent (P value 0.006) while side effects were comparable (P value 0.133). In early-diagnosed preterm labor, nifedipine had higher efficacy than isoxpurine (P value 6.45 × 10−6) and also higher efficacy than its own in late diagnosed preterm labor (P value 2.08 × 10−5).
Conclusions
There is a high incidence of preterm labor in India. Nifedipine is a better tocolytic drug than isoxpurine hydrochloride, especially when started with the earliest signs of preterm labor.
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References
Martin JA, Kochank KD, Strobino DM, et al. Annual summary of vital statistics 2003. Pediatrics. 2005;115:619–39.
Begum F, Buckshee K, Pande JN. Risk factors associated with preterm labor. Bangladesh Med Ras Coune Bull. 2003;29:59–66.
Bibby E, Stewart A. The epidemiology of preterm birth. Neuro Endocrinol Lett. 2004;25:43–7.
Shingairai AF, Siaban DH, Godfrey BW. Risk factors for prematurity at Harare maternity hospital, Zimbabwe. Int J Epidemiol. 2004;33:1194–201.
King JF, Flenady VJ, Papatsonis DNM et al. Calcium channel blockers for inhibiting preterm labor (cochrane review). The cochrane library. Chichester: Wiley; 2004.
Smith CS, Woodland MB. Clinical comparison of oral nifedipine and subcutaneous terbutaline for initial tocolysis. Am J Perinatol. 1993;10:280–4.
Jannet D, Abankwa A, Guyard B, et al. Nicardipine versus salbutamol in the treatment of premature labor. Eur J Obstet Gynecol Reprod Biol. 1997;73:11–6.
Bracero LA, Leikin E, Kirshenbaum N, et al. Comparison of nifedipine and ritodrine for the treatment of preterm labor. Am J Perinatol. 1991;8:365–9.
Papatsonis DN, Van Geijn HP, Adèr HJ, et al. Nifedipine and ritodrine in the management of preterm labor: a randomized multicenter trial. Obstet Gynecol. 1997;90:1023–4.
Kupferminc M, Lessing JB, Yaron Y, et al. Nifedipine versus ritodrine for suppression of preterm labor. Br J Obstet Gynaecol. 1993;100:1090–4.
Garcia-Velasco JA, Gonzalez AG. Prospective, randomized trial of nifedipine versus ritodrine in threatened preterm labor. Int J Gynaecol Obstet. 1998;61:239–44.
Koks CA, Brolmann HA, de Kleine MJ, et al. A randomized comparison of nifedipine and ritodrine for suppression of preterm labor. Eur J Obstet Gynecol Reprod Biol. 1998;77:171–6.
RCOG. Tocolytic drugs for women in preterm labor. In: Clinical guideline no. I (B). London: RCOG Press; 2002.
Acknowledgment
We acknowledge the contribution of all patients and doctors of Department of Obstetrics and Gynecology, CSM Medical University involved in this study.
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Singh, N., Singh, U. & Seth, S. Comparative Study of Nifedipine and Isoxpurine as Tocolytics for Preterm Labor. J Obstet Gynecol India 61, 512–515 (2011). https://doi.org/10.1007/s13224-011-0080-1
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DOI: https://doi.org/10.1007/s13224-011-0080-1