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Exploration of bioactive compounds from Olea dioica in Western Ghats of Karnataka using GC–MS

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Abstract

Bioactive compounds in plants are essential for the formation of novel chemotherapeutic drugs, which have been used in Ayurveda to treat a variety of illnesses. Indian medicinal herbs have been used for thousands of years to treat a variety of illnesses, such as fever, cancer, snake bites, rheumatism, skin problems, and neurodegenerative diseases. GC–MS was used to locate and categorize bioactive components in Olea dioica leaves. The results showed that presence of octanoic acid, methyl ester, decanoic acid, methyl ester, desulphosinigrin, l-gala-l-ido-octose, methyl tetradecanoate, Tetradecanoic acid, 6-benzoxazolesulfonamide, N-(2-hydroxyethyl)-2-methyl-, 10-chloro-5-methoxy-5H-dibenzo[a,d][7]annulene, pentadecanoic acid, oleic acid, n-hexadecanoic acid, hexanedioic acid, dioctyl ester, and squalene. The methanol extract of Olea dioica was effective against a wide spectrum of pathogenic bacteria at four different concentrations, with the highest activity against Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Xanthomonas campestris, and Salmonella typhimurium. It also showed moderate activity against Agrobacterium tumefaciens, Pseudomonas aeruginosa, Streptomyces pneumonia, and Pseudomonas syringae. The pharmacological properties of O. dioica, as well as their variety and comprehensive phytochemistry, could be exploited as a potent antimicrobial agent for future therapeutics.

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Data Availability

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

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Acknowledgements

The authors would like to extend their sincere appreciation to the Taif University Researchers Supporting Project number (TURSP-2020/92), Taif University, Taif, Saudi Arabia.

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Authors and Affiliations

  1. Department of Studies and Research in Biochemistry, Mangalore University, Jnana Kaveri, Chikka Aluvara, Kodagu, Karnataka, India

    Srinivasa Krishnappa, G. K. Pratap & Manjula Shantaram

  2. Department of Studies and Research in Microbiology, Mangalore University, Jnana Kaveri, Chikka Aluvara, Kodagu, Karnataka, India

    Yalpi Karthik

  3. Department of Agricultural Microbiology and Bio-Energy Agricultural College JilleleSircilla, Professor Jayashankar Telangana State Agriculture University, Rajendranagar, Hyderabad, India

    Alavala Umarajashekhar

  4. Department of Microbiology, Government Degree College, Bodhan, Kakatiya University, Warangal, India

    J. Soumya

  5. MS Swaminathan School of Agriculture, Shoolini University of Biotechnology and Management Sciences, Bajhol, Solan, Himachal Pradesh, 173229, India

    Bhagyashree Bhatt & Muntazir Mushtaq

  6. Department of Science and Technology, University College-Ranyah, Taif University, B.O. Box 11099, 21944, Taif, Saudi Arabia

    Samy M. Sayed

  7. Department of Biotechnology, Faculty of Science, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia

    Seham Sater Alhelaify & Ohud Muslat Aharthy

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  1. Srinivasa Krishnappa
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Contributions

SK conducted the research and wrote the manuscript. SK performed the data analyses and reviewed the manuscript. SK, YK, PGK, MS, AU, JS, BB, MM, RC, and HOE edited and reviewed the manuscript. MS provided experimental support. MS planned, supervised, and organized the experiment, wrote and reviewed the manuscript. All authors contributed to the article and approved the submitted version.

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Correspondence to Manjula Shantaram or Muntazir Mushtaq.

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Krishnappa, S., Karthik, Y., Pratap, G.K. et al. Exploration of bioactive compounds from Olea dioica in Western Ghats of Karnataka using GC–MS. 3 Biotech 14, 63 (2024). https://doi.org/10.1007/s13205-023-03888-2

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