Abstract
Human pathogenic diseases received much attention recently due to their uncontrolled spread of antimicrobial resistance (AMR) which causes several threads every year. Effective alternate antimicrobials are urgently required to combat those disease causing infectious microbes. Halophilic actinobacteria revealed huge potentials and unexplored cultivable/non-cultivable actinobacterial species producing enormous antimicrobials have been proved in several genomics approaches. Potential gene clusters, PKS and NRPKS from Nocardia, Salinospora, Rhodococcus, and Streptomyces have wide range coding genes of secondary metabolites. Biosynthetic pathways identification via various approaches like genome mining, In silico, OSMAC (one strain many compound) analysis provides better identification of knowing the active metabolites using several databases like AMP, APD and CRAMPR, etc. Genome constellations of actinobacteria particularly the prediction of BGCs (Biosynthetic Gene Clusters) to mine the bioactive molecules such as pigments, biosurfactants and few enzymes have been reported for antimicrobial activity. Saltpan, saltlake, lagoon and haloalkali environment exploring potential actinobacterial strains Micromonospora, Kocuria, Pseudonocardia, and Nocardiopsis revealed several acids and ester derivatives with antimicrobial potential. Marine sediments and marine macro organisms have been found as significant population holders of potential actinobacterial strains. Deadly infectious diseases (IDs) including tuberculosis, ventilator-associated pneumonia and Candidiasis, have been targeted by halo-actinobacterial metabolites with promising results. Methicillin resistant Staphylococus aureus and virus like Encephalitic alphaviruses were potentially targeted by halophilic actinobacterial metabolites by the compound Homoseongomycin from sponge associated antinobacterium. In this review, we discuss the potential antimicrobial properties of various biomolecules extracted from the unexplored halophilic actinobacterial strains specifically against human infectious pathogens along with prospective genomic constellations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Data availability
All data generated during this study are included in this article.
Code availability
The authors declared that there is no code availability/material used related to this manuscript.
References
Abdelmohsen UR, Yang C, Horn H, Hajjar D, Ravasi T, Hentschel U (2014) Actinomycetes from red sea sponges: Sources for chemical and phylogenetic diversity. Mar Drugs 12:2771–2789. https://doi.org/10.3390/md12052771
Afrifa GF, Kyei-Arthur F, Agyekum MW, Afrifa-Anane EK (2022) Factors associated with comorbidity of diarrhoea and acute respiratory infections among children under five years in Ghana. PLoS ONE 17:1–14. https://doi.org/10.1371/journal.pone.0271685
Ahmed Y, Rebets Y, Tokovenko B, Brötz E, Luzhetskyy A (2017) Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074. Sci Rep 7:1–11. https://doi.org/10.1038/s41598-017-10316-y
Ait Assou S, Anissi J, Sendide K, El Hassouni M (2023) Diversity and antimicrobial activities of actinobacteria isolated from mining soils in Midelt Region, Morocco. Sci World J. https://doi.org/10.1155/2023/6106673
Akova M (2016) Epidemiology of antimicrobial resistance in bloodstream infections. Virulence 7:252–266. https://doi.org/10.1080/21505594.2016.1159366
Alam K, Mazumder A, Sikdar S, Zhao YM, Hao J, Song C, Wang Y, Sarkar R, Islam S, Zhang Y, Li A (2022) Streptomyces: the biofactory of secondary metabolites. Front Microbiol 13:1–21. https://doi.org/10.3389/fmicb.2022.968053
Albarano L, Esposito R, Ruocco N, Costantini M (2020) Genome mining as new challenge in natural products discovery. Mar Drugs 18:199. https://doi.org/10.3390/md18040199
Al-Shaibani MM, Radin Mohamed RM, Sidik NM, Enshasy HA, Al-Gheethi A, Noman E, Al-Mekhlafi NA, Zin NM (2021) Biodiversity of secondary metabolites compounds isolated from phylum actinobacteria and its therapeutic applications. Molecules 26(15):4504
Arifuzzaman M, Khatun MR, Rahman H (2010) Isolation and screening of actinomycetes from Sundarban soil for antibacterial activity. African J Biotechnol 9:4615–4619
Asha GN, Selvakumar D, Dhevendran K (2011) Occurrence of sponge associated streptomyces and its antimicrobial activity. World J Fish Mar Sources 3:151–158
Aslam S, Sajid I (2016) Antimicrobial potential of halophilic actinomycetes against multi drug resistant (MDR) ventilator associated pneumonia causing bacterial pathogens. Pak J Pharm Sci 29(2):367–374 (PMID: 27087086)
Asolkar RN, Kirkland TN, Jensen PR, Fenical W (2010) Arenimycin, an antibiotic effective against rifampin- and methicillin-resistant Staphylococcus aureus from the marine actinomycete Salinispora arenicola. J Antibiot (tokyo) 63:37–39. https://doi.org/10.1038/ja.2009.114
Attene-Ramos MS, Austin CP, Xia M (2014) High throughput screening, 3rd edn. Elsevier, NY
Ayuningrum D, Liu Y, Riyanti, et al (2019) Tunicate-associated bacteria show a great potential for the discovery of antimicrobial compounds. PLoS ONE 14:e0213797
Azman AS, Othman I, Velu SS, Chan KG, Lee LH (2015) Mangrove rare actinobacteria: taxonomy, natural compound, and discovery of bioactivity. Front Microbiol 6:856
Babuselvam M (2013) In vitro antiplasmodial activity of seaweed associated actinomycetes against Plasmodium falciparum. World J Pharm Sci 3:712–720
Babuselvam MA, PanneerSelvam K, Kanimozhi K, Kavitha G (2016) Antibacterial potential of actinomycetes from seagrass against human and aquaculture pathogens. J Microbiol Biotechnol Res 6:32–38
Bairoch A (2000) The ENZYME database in 2000. Nucleic Acids Res 28:304–305. https://doi.org/10.1093/nar/28.1.304
Bakkiyaraj D, Pandian SK (2010) In vitro and in vivo antibiofilm activity of a coral associated actinomycete against drug resistant Staphylococcus aureus biofilms. Biofouling 26:711–717
Balasubramanian S, Skaf J, Holzgrabe U, Bharti R, Forstner KU, Ziebuhr W, Humeida UH, Abdelmohsen UR, Oelschlaeger TA (2018) A new bioactive compound from the marine sponge-derived Streptomyces sp. SBT348 inhibits staphylococcal growth and biofilm formation. Front Microbiol 9:1–18. https://doi.org/10.3389/fmicb.2018.01473
Ballav S, Kerkar S, Thomas S, Augustine N (2015) Halophilic and halotolerant actinomycetes from a marine saltern of Goa, India producing anti-bacterial metabolites. J Biosci Bioeng 119:323–330. https://doi.org/10.1016/j.jbiosc.2014.08.017
Barbosa F, Pinto E, Kijjoa A, Pinto M, Sousa E (2020) Targeting antimicrobial drug resistance with marine natural products. Int J Antimicrob Agents 56(1):106005
Bastos JCS, de Menezes CBA, Fantinatti-Garboggini F et al (2015) Antiviral activity of marine actinobacteria against bovine viral diarrhea virus, a surrogate model of the Hepatitis c virus. RRJMB 4:55–62
Bentley SD, Chater KF, Cerdeño-Tárraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141–147. https://doi.org/10.1038/417141a
Berdi J (2005) Bioactive microbial metabolites. J Antibiot 58:1–26
Betancur LA, Naranjo-Gaybor SJ, Vinchira-Villarraga DM et al (2017) Marine actinobacteria as a source of compounds for phytopathogen control: an integrative metabolic-profiling/bioactivity and taxonomical approach. PLoS ONE 12:e0170148
Betancur LA, Forero AM, Vinchira-Villarraga DM et al (2020) NMR-based metabolic profiling to follow the production of anti-phytopathogenic compounds in the culture of the marine strain Streptomyces sp. PNM-9. Microbiol Res 239:126507
Bhandari S, Bhattarai BR, Adhikari A, Aryal B, Shrestha A, Aryal N, Lamichhane U, Thapa R, Thapa BB, Yadav RP, Khadayat K (2022) Characterization of streptomyces species and validation of antimicrobial activity of their metabolites through molecular docking. Processes 10:1–16. https://doi.org/10.3390/pr10102149
Bhattarai S, Sharma BK, Subedi N, Ranabhat S, Baral MP (2021) Burden of serious bacterial infections and multidrug-resistant organisms in an adult population of nepal: a comparative analysis of minimally invasive tissue sampling informed mortality surveillance of community and hospital deaths. Clin Infect Dis 73:S415–S421. https://doi.org/10.1093/cid/ciab773
Binayke A, Ghorbel S, Hmidet N, Raut A, Gunjal A, Uzgare A, Patil N, Waghmode M, Nawani N (2018) Analysis of diversity of actinomycetes from arid and saline soils at Rajasthan, India. Environ Sustain 1:61–70. https://doi.org/10.1007/s42398-018-0003-5
Blessy Thayalin TS, Prabakaran V (2014) Production of alkaline protease enzymes from marine actinomycetes and its antimicrobial and anti-inflammatory studies using mice model. Asian J Microbiol Biotechnol Environ Sci 16:875–879
Blin K, Shaw S, Kloosterman AM, Charlop-Powers Z, Van Wezel GP, Medema MH, Weber T (2021) AntiSMASH 6.0: Improving cluster detection and comparison capabilities. Nucleic Acids Res 49:W29–W35. https://doi.org/10.1093/nar/gkab335
Blunt JW, Copp BR, Hu WP, Munro MH, Northcote PT, Prinsep MR (2007) Marine natural products. Nat Prod Rep 24:31–86. https://doi.org/10.1039/b603047p
Brana AF, Sarmiento-Vizcaino A, Osset M, Perez-Victoria I, Martin J, De Pedro N, De la Cruz M, Diaz C, Vicente F, Reyes F, Garcia LA (2019) Desertomycin G, a new antibiotic with activity against Mycobacterium tuberculosis and human breast tumor cell lines produced by Streptomyces althioticus MSM3, isolated from the cantabrian sea intertidal macroalgae ulva sp. Mar Drugs 17:144. https://doi.org/10.3390/md17020114
Bruchfeld J, Correia-Neves M, Kallenius G (2015) Tuberculosis and HIV coinfection. Cold Spring Harb Perspect Med 26:a017871. https://doi.org/10.1101/cshperspect.a017871
Buedenbender L, Carroll AR, Ekins M, Kurtböke DI (2017) Taxonomic and metabolite diversity of actinomycetes associated with three Australian ascidians. Diversity 9:53
Bull AT, Stach JEM (2007) Marine actinobacteria: new opportunities for natural product search and discovery. Trends Microbiol 15:491–499. https://doi.org/10.1016/j.tim.2007.10.004
Chandran H, Meena M, Sharma K (2020) Microbial biodiversity and bioremediation assessment through omics approaches. Front Environ Chem 1:570326
Chang A, Jeske L, Ulbrich S, Hofmann J, Koblitz J, Schomburg I, Neumann-Schaal M, Jahn D, Schomburg D (2021) BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res 49:D498–D508. https://doi.org/10.1093/nar/gkaa1025
Chen C, Wang J, Guo H, Hou W, Yang N, Ren B, Liu M, Dai H, Liu X, Song F, Zhang L (2013) Three antimycobacterial metabolites identified from a marine-derived Streptomyces sp. MS100061. Appl MicrobiolBiotechnol 97:3885–3892. https://doi.org/10.1007/s00253-012-4681-0
Citarasu T, Thirumalaikumar E, Abinaya P, Babu MM, Uma G (2021) Biosurfactants from halophilic origin and their potential applications. Green sustainable process for chemical and environmental engineering and science. Elsevier, pp 489–521. https://doi.org/10.1016/B978-0-12-823380-1.00019-8
Claverías FP, Undabarrena A, González M, Seeger M, Camara B (2015) Culturable diversity and antimicrobial activity of actinobacteria from marine sediments in Valparaíso Bay, Chile. Front Microbiol 6:1–11. https://doi.org/10.3389/fmicb.2015.00737
Coradini AL, Hull CB, Ehrenreich IM (2020) Building genomes to understand biology. Nat Commun 11:6177
Corral P, Amoozegar MA, Ventosa A (2019) Halophiles and their biomolecules: recent advances and future applications in biomedicine. Mar Drugs 18:33
Crits-Christoph A, Gelsinger DR, Ma B et al (2016) Functional interactions of archaea, bacteria and viruses in a hypersaline endolithic community. Environ Microbiol 18:2064–2077
Cumsille A, Undabarrena A, González V, Claverías F, Rojas C, Cámara B (2017) Biodiversity of actinobacteria from the south pacific and the assessment of streptomyces chemical diversity with metabolic profiling. Mar Drugs 15:286. https://doi.org/10.3390/md15090286
Cycil LM, DasSarma S, Pecher W, McDonald R, Abdul Salam M, Hasan F (2020) Metagenomic insights into the diversity of halophilic microorganisms indigenous to the Karak Salt Mine, Pakistan. Front Microbiol 11:1–14. https://doi.org/10.3389/fmicb.2020.0156
Das A, Bhattacharya S, Mohammed AYH, Rajan SS (2014) In vitro antimicrobial activity and characterization of mangrove isolates of streptomycetes effective against bacteria and fungi of nosocomial origin. Brazil Arch Biol Technol 57:349–356
Das R, Romi W, Das R, Sharma HK, Thakur D (2018) Antimicrobial potentiality of actinobacteria isolated from two microbiologically unexplored forest ecosystems of Northeast India. BMC Microbiol 18:1–6
Dashti Y, Grkovic T, Quinn RJ (2014) Predicting natural product value, an exploration of anti-TB drug space. Nat Prod Rep 31:990–998
De La Hoz-Romo MC, Díaz L, Villamil L (2022) Marine actinobacteria a new source of antibacterial metabolites to treat acne vulgaris disease-a systematic literature review. Antibiotics (basel) 11:965. https://doi.org/10.3390/antibiotics11070965
de Menezes CBA, Afonso RS, de Souza WR, Parma MM, de Melo IS, Fugita FLS, Moraes LAB, Zucchi TD, Fantinatti-Garboggini F (2019) Williamsia aurantiacus sp. nov. a novel actinobacterium producer of antimicrobial compounds isolated from the marine sponge. Arch Microbiol 201:691-698. https://doi.org/10.1007/s00203-019-01633-z
De Oliveira DMP, Forde BM, Kidd TJ et al (2020) Antimicrobial resistance in ESKAPE pathogens. Clin Microbiol Rev 33:10–1128
De Simeis D, Serra S (2021) Actinomycetes: A never-ending source of bioactive compounds—an overview on antibiotics production. Antibiotics 10(5):483
Dhakal D, Pokhrel AR, Shrestha B, Sohng JK (2017) Marine rare actinobacteria: Isolation, characterization, and strategies for harnessing bioactive compounds. Front Microbiol 8:1106. https://doi.org/10.3389/fmicb.2017.01106
Ding L, Maier A, Fiebig HH, Gorls H, Lin WH, Peschel G, Hertweck C (2011) Divergolidesa A-D from a mangrove endophyte reveal an unparalleled plasticity in ansa-macrolide biosynthesis. Angew Chemie - Int Ed 50:1630–1634. https://doi.org/10.1002/anie.201006165
Duddu MK, Guntuku G (2015) Isolation and partial characterization of actinomycetes from mangrove sediment samples. J Glob Biosci 4:2921–2929
Edlund A, Loesgen S, Fenical W, Jensen PR (2011) Geographic distribution of secondary metabolite genes in the marine actinomycete Salinispora arenicola. Appl Environ Microbiol 77:5916–5925. https://doi.org/10.1128/AEM.00611-11
El-Naggar MY, Barakat KM, Aly NS (2016) Physiological response, antibacterial activity and cinnamaldehyde production by a marine Streptomyces chartreusis. J Pure Appl Microbiol 10:1797–1808
Fiedler HP, Bruntner C, Bull AT, Ward AC, Goodfellow M, Potterat O, Puder C, Mihm G (2005) Marine actinomycetes as a source of novel secondary metabolites. Antonie Van Leeuwenhoek 87:37–42. https://doi.org/10.1007/s10482-004-6538-8
Flores-Clavo R, Ruiz-Quinones N, Hernández-Tasco ÁJ, Jose-Salvador M, Tasca Gois Ruiz AL, de Oliveira Braga LE, Henrique Costa J, Pacheco Fill T, Arce Gil ZL, Serquen Lopez LM, Fantinatti Garboggini F (2021) Evaluation of antimicrobial and antiproliferative activities of actinobacteria isolated from the saline lagoons of northwestern Peru. PLoS ONE 16(9):e0240946
Fu P, Wang S, Hong K et al (2011) Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. J Nat Prod 74:1751–1756
Genilloud O, González I, Salazar O et al (2011) Current approaches to exploit actinomycetes as a source of novel natural products. J Ind Microbiol Biotechnol 38:375–389
Giddins MJ, Macesic N, Annavajhala MK, Stump S, Khan S, McConville TH, Mehta M, Gomez-Simmonds A, Uhlemann AC (2018) Successive emergence of ceftazidime-avibactam resistance through distinct genomic adaptations in bla KPC-2-harboring Klebsiella pneumoniae sequence type 307 isolates. Antimicrob Agents Chemother 62:e02101-e2117. https://doi.org/10.1128/AAC.02101-17
Girao M, Ribeiro I, Ribeiro T, Azevedo IC, Pereira F, Urbatzka R (2019) Actinobacteria isolated from laminaria ochroleuca: a source of new bioactive compounds. Front in Microbiol 10:683
Gohel SD, Sharma AK, Dangar KG et al (2015) Antimicrobial and biocatalytic potential of haloalkaliphilic actinobacteria. Halophiles biodivers sustain exploit. Springer, Cham, pp 29–55
Gomez-Escribano JP, Alt S, Bibb MJ (2016) Next generation sequencing of actinobacteria for the discovery of novel natural products. Mar Drugs 14:78
Gomez-Villegas P, Vigara J, Vila M, Varela J, Barreira L, Léon R (2020) Antioxidant, antimicrobial, and bioactive potential of two new haloarchaeal strains isolated from odiel salterns (Southwest Spain). Biology (basel) 9:1–20. https://doi.org/10.3390/biology9090298
Gozari M, Bahador N, Mortazavi MS, Eftekhar E, Jassbi AR (2019) An “olivomycin A” derivative from a sponge-associated Streptomyces sp. strain SP 85. 3 Biotech 9:1–11. https://doi.org/10.1007/s13205-019-1964-5
Gupta S, Sharma P, Dev K, Srivastava M, Sourirajan A (2015) A diverse group of halophilic bacteria exist in Lunsu, a natural salt water body of Himachal Pradesh, India. Springer plus 4:1–9. https://doi.org/10.1186/s40064-015-1028-1
Haft DH, Selengut JD, Richter RA, Harkins D, Basu MK, Beck E (2013) TIGRFAMs and genome properties in 2013. Nucleic Acids Res 41:387–395. https://doi.org/10.1093/nar/gks1234
Hamed MM, Abdrabo MAA, Youssif AM (2021) Biosurfactant production by marine actinomycetes isolates Streptomyces althioticus RG3 and Streptomyces californicus RG8 as a promising source of antimicrobial and antifouling effects. Microbiol Biotechnol Lett 49:356–366
Hassane SC, Fouillaud M, Le Goff G, Sklirou AD, Boyer JB, Trougakos IP, Jerabek M, Bignon J, de Voogd NJ, Ouazzani J, Gauvin-Bialecki A (2020) Microorganisms associated with the marine sponge scopalinahapalia: a reservoir of bioactive molecules to slow down the aging process. Microorganisms 8:1–23. https://doi.org/10.3390/microorganisms8091262
Hayakawa Y, Shirasaki S, Shiba S, Kawasaki T, Matsuo Y, Adachi K, Shizuri Y (2007) Piericidins C7 and C8, new cytotoxic antibiotics produced by a marine Streptomyces sp. J Antibiot (tokyo) 60:196–200. https://doi.org/10.1038/ja.2007.22
Helou M, Van Berlaer G, Yammine K (2022) Factors influencing the occurrence of infectious disease outbreaks in Lebanon since the Syrian crisis. Pathog Glob Health 116:13–21. https://doi.org/10.1080/20477724.2021.1957192
Henciya S, Vengateshwaran TD, Gokul MS, Dahms HU, James RA (2020) Antibacterial activity of halophilic bacteria against drug-resistant microbes associated with diabetic foot infections. Curr Microbiol 77:3711–3723. https://doi.org/10.1007/s00284-020-02190-1
Herc ES, Kauffman CA, Marini BL, Perissinotti AJ, Miceli MH (2017) Daptomycin nonsusceptible vancomycin resistant Enterococcus bloodstream infections in patients with hematological malignancies: risk factors and outcomes. Leuk Lymphoma 58:2852–2858. https://doi.org/10.1080/10428194.2017.1312665
Huang H, Yao Y, He Z, Yang T, Ma J, Tian X, Li Y, Huang C, Chen X, Li W, Zhang S (2011) Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate. J Nat Prod 74:2122–2127. https://doi.org/10.1021/np200399t
Hug JJ, Bader CD, Remškar M, Cirnski K, Müller R (2018) Concepts and methods to access novel antibiotics from actinomycetes. Antibiotics 7:44. https://doi.org/10.3390/antibiotics7020044
Hussein EI, Jacob JH, Shakhatreh MAK et al (2018) Detection of antibiotic-producing Actinobacteria in the sediment and water of Ma’in thermal springs (Jordan). Germs 8:191
Ian E, Malko DB, Sekurova ON, Bredholt H, Rückert C, Borisova ME, Albersmeier A, Kalinowski J, Gelfand MS, Zotchev SB (2014) Genomics of sponge-associated Streptomyces spp. closely related to Streptomyces albus J1074: Insights into marine adaptation and secondary metabolite biosynthesis potential. PLoS ONE 9:e96719. https://doi.org/10.1371/journal.pone.0096719
Igarashi M, Nakagawa N, Doi N, Hattori S, Naganawa H, Hamada M (2003) Caprazamycin B, a novel anti-tuberculosis antibiotic, from Streptomyces sp. J Antibiot (tokyo) 56:580–583
Indupalli M, Muvva V, Mangamuri U, Munaganti RK, Naragani K (2018) Bioactive compounds from mangrove derived rare actinobacterium Saccharomonospora oceani VJDS-3. 3 Biotech 8:1–9. https://doi.org/10.1007/s13205-018-1093-6
Iniyan AM, Mary TR, Joseph FJ, Kannan RR, Vincent SG (2016) Cell wall distracting anti-Methicillin-resistant Staphylococcus aureus compound PVI331 from a marine sponge associated Streptomyces. J Appl Biomed 14:273–283. https://doi.org/10.1016/j.jab.2016.04.003
Iskandar K, Murugaiyan J, Hammoudi Halat D, Hage SE, Chibabhai V, Adukkadukkam S, Roques C, Molinier L, Salameh P, Van Dongen M (2022) Antibiotic discovery and resistance: the chase and the race. Antibiotics 11(2):182
Izumikawa M, Khan ST, Takagi M, Shin-ya K (2010) Sponge-derived streptomyces producing isoprenoids via the mevalonate pathway. J Nat Prod 73:208–212
Jackson SA, Crossman L, Almeida EL, Margassery LM, Kennedy J, Dobson AD (2018) Diverse and abundant secondary metabolism biosynthetic gene clusters in the genomes of marine sponge derived Streptomyces spp. Isolates Mar Drugs 16:1–18. https://doi.org/10.3390/md16020067
Jagannathan SV, Manemann EM, Rowe SE, Callendr MC, Soto W (2021) Marine actinomycetes, new sources of biotechnological products. Mar Drugs 19:365. https://doi.org/10.3390/md19070365
Jain M, Olsen HE, Paten B, Akeson M (2016) The Oxford Nanopore MinION: delivery of nanopore sequencing to the genomics community. Genome Biol 17:1–11
James RD, William WM (2013) Comparative genomics of actinomycetes with a focus on natural product biosynthetic genes. BMC Genom 14:611
Janaki T, Nayak BK, Ganesan T (2016) Antifungal activity of soil actinomycetes from the mangrove Avicennia marina. J Med Plants Stud 4:05–08
Jensen PR, Williams PG, Oh DC, Zeigler L, Fenical W (2007) Species-specific secondary metabolite production in marine actinomycetes of the genus Salinispora. Appl Environ Microbiol 73:1146–1152. https://doi.org/10.1128/AEM.01891-06
Johnson CK, Hitchens PL, Pandit PS et al (2020) Global shifts in mammalian population trends reveal key predictors of virus spillover risk. Proc R Soc B 287:20192736
Jose PA, Jha B (2017) Intertidal marine sediment harbours actinobacteria with promising bioactive and biosynthetic potential. Sci Rep 7:1–15. https://doi.org/10.1038/s41598-017-09672-6
Jose PA, Maharshi A, Jha B (2021) Actinobacteria in natural products research: progress and prospects. Microbiol Res 246:126708. https://doi.org/10.1016/j.micres.2021.126708
Joseph FJRS, Iniyan AM, Vincent SGP (2017) HR-LC-MS based analysis of two antibacterial metabolites from a marine sponge symbiont Streptomyces pharmamarensis ICN40. Microb Pathog 111:450–457. https://doi.org/10.1016/j.micpath.2017.09.033
Ju K-S, Nair SK (2022) Convergent and divergent biosynthetic strategies towards phosphonic acid natural products. Curr Opin Chem Biol 71:102214
Ju K-S, Gao J, Doroghazi JR et al (2015) Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proc Natl Acad Sci 112:12175–12180
Kadiri SK, Yarla NS, Vidavalur S (2014) Screening and isolation of antagonistic actinobacteria associated with marine sponges from Indian coast. J Microb Biochem Technol S 8:003
Kalinovskaya NI, Kalinovsky AI, Romanenko LA, Dmitrenok PS, Kuznetsova TA (2010) New angucyclines and antimicrobial diketopiperazines from the marine mollusk-derived actinomycete Saccharothrix espanaensis An 113. Nat Prod Commun 5:597–602
Kamjam M, Sivalingam P, Deng Z, Hong K (2017) Deep sea actinomycetes and their secondary metabolites. Front Microbiol 8:760. https://doi.org/10.3389/fmicb.2017.00760
Kanehisa M, Furumichi M, Tanabe M, Sato Y, Morishima K (2017) KEGG: new perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res 45:D353–D361. https://doi.org/10.1093/nar/gkw1092
Khan ST, Komaki H, Motohashi K, Kozone I, Mukai A, Takagi M (2011) Streptomyces associated with a marine sponge Haliclona spp.; biosynthetic genes for secondary metabolites and products. Environ Microbiol 13:391–403
Khopade A, Ren B, Liu XY, Mahadik K, Zhang L, Kokare C (2012) Production and characterization of biosurfactant from marine Streptomyces species B3. J Colloid Interface Sci 367:311–318. https://doi.org/10.1016/j.jcis.2011.11.009
Kim TK, Hewavitharana AK, Shaw PN, Fuerst JA (2006) Discovery of a new source of rifamycin antibiotics in marine sponge actinobacteria by phylogenetic prediction. Appl Environ Microbiol 72:2118–2125
Kinashi H, Shimaji M, Sakai A (1988) Giant linear plasmids in Streptomyces which code for antibiotic biosynthesis genes. Nature 328:454–456. https://doi.org/10.1038/328454a0
Kubicki S, Bollinger A, Katzke N, Jaeger KE, Loeschcke A, Thies S (2019) Marine biosurfactants: biosynthesis, structural diversity and biotechnological applications. Mar Drugs 17:408
Kügler JH, Le Roes-Hill M, Syldatk C, Hausmann R (2015) Surfactants tailored by the class actinobacteria. Front Microbiol 6:212
Lach J, Jęcz P, Strapagiel D et al (2021) The methods of digging for “Gold” within the salt: characterization of halophilic prokaryotes and identification of their valuable biological products using sequencing and genome mining tools. Genes (basel) 12:1756
Lage OM, Ramos MC, Calisto R, Almeida E, Vasconcelos V, Vicente F (2018) Current screening methodologies in drug discovery for selected human diseases. Mar Drugs 16:279
Lal D, Lal R (2011) Discovering metabolic products of cryptic biosynthetic pathways. Indian J Microbiol 51(3):414
Lanteri MC, Santa-Maria F, Laughhunn A et al (2020) Inactivation of a broad spectrum of viruses and parasites by photochemical treatment of plasma and platelets using amotosalen and ultraviolet A light. Transfusion 60:1319–1331
Leiva S, Alvarado P, Huang Y et al (2015) Diversity of pigmented gram-positive bacteria associated with marine macroalgae from Antarctica. FEMS Microbiol Lett 362:fnv206
Letunic I, Khedkar S, Bork P (2021) SMART: Recent updates, new developments and status in 2020. Nucleic Acids Res 49:D458–D460. https://doi.org/10.1093/nar/gkaa937
Li S, Tian X, Niu S, Zhang W, Chen Y, Zhang H, Yang X, Zhang W, Li W, Zhang S, Ju J (2011) Pseudonocardians A-C, new diazaanthraquinone derivatives from a deap-sea actinomycete Pseudonocardiasp. SCSIO 01299. Mar Drugs 9:1428–1439. https://doi.org/10.3390/md9081428
Li R, Wang M, Ren Z, Ji Y, Yin M, Zhou H, Tang SK (2021) Amycolatopsisaidingensis sp. nov., a halotolerant actinobacterium, produces new secondary metabolites. Front Microbiol 12:1–11. https://doi.org/10.3389/fmicb.2021.743116
Lin SC, Lehman CW, Stewart AK, Panny L, Bracci N, Wright JL, Paige M, Strangman WK, Kehn-Hall K (2021) Homoseongomycin, a compound isolated from marine actinomycete bacteria K3–1, is a potent inhibitor of encephalitic alphaviruses. Antiviral Res 191:105087. https://doi.org/10.1016/j.antiviral.2021.105087
Liu T, Wu S, Zhang R, Wang D, Chen J, Zhao J (2019) Diversity and antimicrobial potential of actinobacteria isolated from diverse marine sponges along the Beibu Gulf of the South China Sea. FEMS Microbiol Ecol 95:1–10. https://doi.org/10.1093/femsec/fiz089
Lubsanova DA, Zenova GM, Kozhevin PA, Manucharova NA, Shvarov AP (2014) Filamentous actinobacteria of the saline soils of arid territories. Mosc Univ Soil Sci Bull 69:88–92. https://doi.org/10.3103/s0147687414020057
Ma NJ, Moonan DW, Isaacs FJ (2014) Precise manipulation of bacterial chromosomes by conjugative assembly genome engineering. Nat Protoc 9:2285–2300
Magarvey NA, Keller JM, Bernan V et al (2004) Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Appl Environ Microbiol 70:7520–7529
Mahmoud HM, Kalendar AA (2016) Coral-associated Actinobacteria: Diversity, abundance, and biotechnological potentials. Front Microbiol 7:1–13. https://doi.org/10.3389/fmicb.2016.00204
Maithani D, Sharma A, Gangola S et al (2022) Insights into applications and strategies for discovery of microbial bioactive metabolites. Microbiol Res 261:127053
Majithiya VR, Gohel SD (2022) Actinobacteria associated with marine invertebrates diversity and biological significance. Actinobacteria-diversity, applications and medical aspects. Intech Open
Maldonado LA, Fragoso-Yáñez D, Pérez-García A, Rosellón-Druker J, Quintana ET (2009) Actinobacterial diversity from marine sediments collected in Mexico. Antonie Van Leeuwenhoek 95:111–120. https://doi.org/10.1007/s10482-008-9294-3
Mangamuri UK, Vijayalakshmi M, Poda S, Manavathi B, Chitturi B, Yenamandra V (2016) Isolation and biological evaluation of N-(4-aminocyclooctyl)-3, 5-dinitrobenzamide, a new semisynthetic derivative from the Mangrove-associated actinomycete Pseudonocardia endophytica VUK-10. 3 Biotech 6:1–12. https://doi.org/10.1007/s13205-016-0472-0
Manigundan K, Revathy S, Sivarajan A, Anbarasu S, Jerrine J, Radhakrishnan M, Balagurunathan R (2019) Bioactive potential of selected actinobacterial strains against Mycobacterium tuberculosis and other clinical pathogens. Indian J Geo-Marine Sci 48:1307–1311
Manikandan M, Gowdaman V, Duraimurugan K, Prabagaran SR (2019) Taxonomic characterization and antimicrobial compound production from Streptomyces chumphonensis BDK01 isolated from marine sediment. 3 Biotech 9:1–13. https://doi.org/10.1007/s13205-019-1687-7
Martinez-Nunez MA, Lopez VEL, y, (2016) Nonribosomal peptides synthetases and their applications in industry. Sustain Chem Process 4:1–8. https://doi.org/10.1186/s40508-016-0057-6
McArthur DB (2019) Emerging infectious diseases. Nurs Clin 54:297–311
Melander RJ, Melander C (2017) The challenge of overcoming antibiotic resistance: an adjuvant approach? ACS Infect Dis 3:559–563. https://doi.org/10.1021/acsinfecdis.7b00071
Melander RJ, Mattingly AE, Nemeth AM, Melander C (2023) Overcoming intrinsic resistance in gram-negative bacteria using small molecule adjuvants Bioorg Med Chem Lett 80:129113. https://doi.org/10.1016/j.bmcl.2022.129113
Metelev M, Tietz JI, Melby JO, Blair PM, Zhu L, Livnat I, Severinov K, Mitchell DA (2015) Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso peptide from an understudied halophilic actinomycete. Chem Biol 22:241–250. https://doi.org/10.1016/j.chembiol.2014.11.017
Mobberley JM, Lindemann SR, Bernstein HC et al (2017) Organismal and spatial partitioning of energy and macronutrient transformations within a hypersaline mat. FEMS Microbiol Ecol 93:fix028
Moopantakath J, Imchen M, Athira CH, Kumavath R (2021) Metagenomic approaches for exploration of halophilic prokaryotes in coastal areas. Metagenomics and microbial ecology. CRC Press, pp 63–78
Morse SS (1995) Factors in the emergence of infectious diseases. Emerg Infect Dis 1:7–15. https://doi.org/10.3201/eid0101.950102
Motohashi K, Takagi M, Shin-ya K (2011) Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23. J Nat Prod 73:226–228
Murray CJL, Ikuta KS, Sharara F et al (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399:629–655
Naghoni A, Emtiazi G, Amoozegar MA et al (2017) Microbial diversity in the hypersaline Lake Meyghan, Iran. Sci Rep 7:11522
Nakano M, Kihara M, Iehata S, Tanaka R, Maeda H, Yoshikawa T (2011) Wax ester-like compounds as biosurfactants produced by Dietziamaris from n -alkane as a sole carbon source. J Basic Microbiol 51:490–498. https://doi.org/10.1002/jobm.201000420
Naylor NR, Atun R, Zhu N, Kulasabanathan K, Silva S, Chatterjee A, Knight GM, Robotham JV (2000) Estimating the burden of antimicrobial resistance: a systematic literature review. Antimicrob Resist Infect Control 7:1–17
Newman DJ, Cragg GM (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod 70:461–477. https://doi.org/10.1021/np068054v
Ng ZY, Tan GYA (2018) Selective isolation and characterisation of novel members of the family Nocardiopsaceae and other actinobacteria from a marine sediment of Tioman Island. Antonie Van Leeuwenhoek 111:727–742
Ngamcharungchit C, Chaimusik N, Panbangred W et al (2023) Bioactive metabolites from terrestrial and marine actinomycetes. Molecules 28:5915
Oh DC, Kauffman CA, Jensen PR, Fenical W (2008) Induced production of emericellamides A and B from the marine-derived fungus Emericella sp. in competing co-culture. J Nat Prod 70:515–520. https://doi.org/10.1021/np060381f
O'Neill J (2014) Review on antimicrobial resistance. Antimicrobial resistance: tackling a crisis for the health and wealth of nations. http://amr-review.org
Oner O, Ekiz G, Hameş E, Demir V, Gube O, Ozkaya F (2014) Cultivable sponge-associated actinobacteria from coastal area of Eastern Mediterranean Sea. Adv Microbiol 4:306–316. https://doi.org/10.4236/aim.2014.46037
Oueriaghli N, Castro DJ, Llamas I, Béjar V, Martínez-Checa F (2018) Study of bacterial community composition and correlation of environmental variables in Rambla Salada, a hypersaline environment in South-Eastern Spain. Front Microbiol 9:1–17. https://doi.org/10.3389/fmicb.2018.01377
Oulas A, Pavloudi C, Polymenakou P et al (2015) Metagenomics: tools and insights for analyzing next-generation sequencing data derived from biodiversity studies. Bioinform Biol Insights 9:BBI-S12462
Parrot D, Antony-Babu S, Intertaglia L, Grube M, Tomasi S, Suzuki MT (2015) Littoral lichens as a novel source of potentially bioactive actinobacteria. Scient Rep 5:1–14
Pathak M, Verma TK, Kalita D, Sankari D (2012) Antimicrobial properties of marine bacteria isolated from the Bay of Bengal and their pharmaceutical prospects as antibiotics against multi drug resistant pathogens. Int J Pharm Pharm Sci 4:260–263
Peng X, Zhou H, Yao H, Li J, Tang S, Jiang L, Wu Z (2007) Microbe-related precipitation of iron and silica in the Edmond deep-sea hydrothermal vent field on the Central Indian Ridge. Chin Sci Bull 52:3233–3238. https://doi.org/10.1007/s11434-007-0523-3
Peng X, Chen S, Zhou H, Zhang L, Wu Z, Li J, Li J, Xu H (2011) Diversity of biogenic minerals in low-temperature Si-rich deposits from a newly discovered hydrothermal field on the ultraslow spreading southwest Indian ridge. J Geophys Res Biogeosciences 116:1–18. https://doi.org/10.1029/2011JG001691
Peterson E, Kaur P (2018) Antibiotic resistance mechanisms in bacteria: relationships between resistance determinants of antibiotic producers, environmental bacteria, and clinical pathogens. Front Microbiol 9:1–21. https://doi.org/10.3389/fmicb.2018.02928
Petrillo C, Castaldi S, Lanzilli M, Selci M, Cordone A, Giovannelli D, Isticato R (2021) Genomic and physiological characterization of bacilli isolated from salt-pans with plant growth promoting features. Front Microbiol 12:715678. https://doi.org/10.3389/fmicb.2021.715678
Plominsky AM, Henríquez-Castillo C, Delherbe N et al (2018) Distinctive archaeal composition of an artisanal crystallizer pond and functional insights into salt-saturated hypersaline environment adaptation. Front Microbiol 9:1800
Prabahar C, Saleshrani K, Enbarasan R (2014) Isolation and characterization of marine actinomycetes from Muthuppettai Mangroves in Tamilnadu, India. Inter J Rec Scient Res 5:906–910
Prestinaci F, Pezzotti P, Pantosti A (2015) Antimicrobial resistance: a global multifaceted phenomenon. Pathog Glob Health 109:309–318. https://doi.org/10.1179/2047773215Y.0000000030
Priya E, Nagasathya A, Steffi PF, Thamilmaraiselvi B (2020) Characterization of actinobacteria isolated from saltpan, environment of thondi, ramanathapuram dt. Res J Pharm Technol 13:5108–5114. https://doi.org/10.5958/0974-360X.2020.00894.X
Priyadarshini A, Singdevsachan SK, Tripathy SK, Mohanta YK, Patra JK, Sethi BK (2016) Isolation and identification of actinomycetes from mangrove soil and extraction of secondary metabolites for antibacterial activity. Br Biotechnol J 12:1–13
Priyanka S, Jayashree M, Shivani R, Anwesha S, Rao KB (2019) Characterisation and identification of antibacterial compound from marine actinobacteria: in vitro and in silico analysis. J Infect Public Health 12:83–89. https://doi.org/10.1016/j.jiph.2018.09.005
Qu JH, Fu YH, Yue YF, Li HF (2019) Description of Ornithinibacillus gellani sp. nov., a halophilic bacterium isolated from lake sediment, and emended description of the genus Ornithinibacillus. Int J Syst Evol Microbiol 69:2632-2637. https://doi.org/10.1099/ijsem.0.003500
Quan D, Nagalingam G, Payne R, Triccas JA (2017) New tuberculosis drug leads from naturally occurring compounds. Int J Infect Dis 56:212–220
Rajivgandhi G, Vijayan R, Kannan M, Santhanakrishnan M, Manoharan N (2016) Molecular characterization and antibacterial effect of endophytic actinomycetes Nocardiopsissp. GRG1 (KT235640) from brown algae against MDR strains of uropathogens. Bioact Mater 1:140–150
Rajkumar J, Sivakumar K, Thangaradjou T (2016) Characterization of actinobac. Population in the seagrass rhizosphere soils of the Gulf of Mannar biosphere reserve, India. Res J Microbiol 11:1–10
Ramachandran G, Rajivgandhi G, Maruthupandy M, Manoharan N (2018) Isolation and identification of antibacterial compound from marine endophytic actinomycetes against multi drug resistant bacteria. Annals Microbiol Immunol 1:1–6
Ramirez-Duran N, de la Haba RR, Vera-Gargallo B et al (2021) Taxogenomic and comparative genomic analysis of the genus Saccharomonospora focused on the identification of biosynthetic clusters PKS and NRPS. Front Microbiol 12:603791
Ramsamy Y, Mlisana KP, Amoako DG, Abia AL, Ismail A, Allam M, Mbanga J, Singh R, Essack SY (2022) Mobile genetic elements-mediated Enterobacterales-associated carbapenemase antibiotic resistance genes propagation between the environment and humans: a one health south African study. Sci Total Environ 806:150641
Rangseekaew P, Pathom-Aree W (2019) Cave actinobacteria as producers of bioactive metabolites. Front Microbiol 22(10):387
Ravikumar S, Krishnakumar S, Jacob Inbaneson S, Gnanadesigan M (2010) Antagonistic activity of marine actinomycetes from the Arabian Sea coast. Arc Appl Sci Res 2:273–280
Ribeiro I, Girao M, Alexandrino DA, Ribeiro T, Santos C, Pereira F, Mucha AP, Urbatzka R, Leao PN, Carvalho MF (2020) Diversity and bioactive potential of actinobacteria isolated from a coastal marine sediment in Northern Portugal. Microorganisms 8:1–16. https://doi.org/10.3390/microorganisms8111691
Riedlinger J, Reicke A, Zähner HA, Krismer B, Bull AT, Maldonado LA, Ward AC, Goodfellow M, Bister B, Bischoff D, Süssmuth RD (2004) Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032. J Antibiot 57:271–279. https://doi.org/10.7164/antibiotics.57.271
Romano S, Jackson SA, Patry S, Dobson ADW (2018) Extending the “one strain many compounds” (OSMAC) principle to marine microorganisms. Mar Drugs 16:244
Saha M, Sarkar A (2021) Review on multiple facets of drug resistance: a rising challenge in the 21st century. J Xenobiotics 11:197–214. https://doi.org/10.3390/jox11040013
Sahoo SR, Goli D, Maringanti B (2019) Studies of two pigment producing halophilic bacteria from Karnataka mangrove soil. Indian J Pharm Sci 81:892–899. https://doi.org/10.36468/pharmaceutical-sciences.584
Saker R, Meklat A, Bouras N et al (2015) Diversity and antagonistic properties of culturable halophilic actinobacteria in soils of two arid regions of septentrional Sahara: M’zab and Zibans. Ann Microbiol 65:2241–2253
Salwan R, Sharma V (2020) Molecular and biotechnological aspects of secondary metabolites in actinobacteria. Microbiol Res 231:126374
Sanchez LM, Wong WR, Riener RM, Schulze CJ, Linington RG (2012) Examining the fish microbiome: vertebrate-derived bacteria as an environmental niche for the discovery of unique marine natural products. PLoS ONE 7(5):e35398. https://doi.org/10.1371/journal.pone.0035398
Santhaseelan H, Dinakaran VT, Dahms HU, Ahamed JM, Murugaiah SG, Krishnan M, Hwang JS, Rathinam AJ (2022a) Recent antimicrobial responses of halophilic microbes in clinical pathogens. Microorganisms 10:1–19. https://doi.org/10.3390/microorganisms10020417
Santhaseelan H, Dinakaran VT, Sakthivel B, Somasundaram M, Thanamegam K, Devendiran V, Dahms HU, Rathinam AJ (2022b) Bioactive efficacy of novel carboxylic acid from halophilic Pseudomonas aeruginosa against methicillin-resistant Staphylococcus aureus. Metabolites 12:1094. https://doi.org/10.3390/metabo12111094
Santos JD, Vitorino I, De la Cruz M, Díaz C, Cautain B, Annang F, Lage OM, Pérez-Moreno G, Martinez IG, Tormo JR et al (2019) Bioactivities and extract dereplication of actinomycetales isolated from marine sponges. Front Microbiol 10:727. https://doi.org/10.3389/fmicb.2019.00727
Santos-Júnior CD, Pan S, Zhao XM, Coelho LP (2020) Macrel: antimicrobial peptide screening in genomes and metagenomes. PeerJ 8:1–20. https://doi.org/10.7717/peerj.10555
Sarafin Y, Donio MB, Velmurugan S, Michaelbabu M, Citarasu T (2014) Kocuria marina BS-15 a biosurfactant producing halophilic bacteria isolated from solar salt works in India. Saudi J Biol Sci 21:511–519. https://doi.org/10.1016/j.sjbs.2014.01.001
Sarkar G, Suthindhiran K (2022) Diversity and biotechnological potential of marine actinomycetes from India. Ind J Microbiol 62:475–493
Sato S, Iwata F, Yamada S, Katayama M (2012) NeomaclafunginsA-I: oligomycin-class macrolides from a marine-derived actinomycete. J Nat Prod 75:1974–1982
Scherlach K, Hertweck C (2021) Mining and unearthing hidden biosynthetic potential. Nat Commun 12:3864
Schinke C, Martins T, Queiroz SCN, Melo IS, Reyes FGR (2017) Antibacterial compounds from marine bacteria, 2010–2015. J Nat Prod 80:1215–1228
Schneemann I, Nagel K, Kajahn I, Labes A, Wiese J, Imhoff JF (2010) Comprehensive investigation of marine actinobacteria associated with the sponge Halichondria panacea. Appl Environ Microbiol 76:3702–3714
Schulze CJ, Navarro G, Ebert D, Derisi J, Linington RG (2015) Salinipostins A-K, long-chain bicyclic phosphotriesters as a potent and selective antimalarial chemotype. J Org Chem 80:1312–1320
Selim MSM, Abdelhamid SA, Mohamed SS (2021) Secondary metabolites and biodiversity of actinomycetes. J Genet Eng Biotechnol 19:72
Selvarajan R, Sibanda T, Tekere M et al (2017) Diversity analysis and bioresource characterization of halophilic bacteria isolated from a south African saltpan. Molecules 22:657
Sengupta S, Pramanik A, Ghosh A, Bhattacharyya M (2015) Antimicrobial activities of actinomycetes isolated from unexplored regions of Sundarbans mangrove ecosystem. BMC Microbiol 15:1–16
Sharma P, Thakur D (2020) Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India. Sci Rep 10:4104
Sheeja MS, Selvakumar D, Dhevendaran K (2011) Antagonistic potential of Streptomyces associated with the gut of marine ornamental fishes. Middle-East J Sci Res 7:327–334
Shuikan AM, Alshuwaykan RM, Arif IA (2023) The role of metagenomic approaches in the analysis of microbial community in extreme environment
Siddarthan S, Ravishankar Rai V, Wink J, Steinert M (2020) Diversity and bioactive potential of actinobacteria from unexplored regions of Western Ghats, India. Microorganisms 8:1–14. https://doi.org/10.3390/microorganisms8020225
Silva-Castro GA, Moyo AC, Khumalo L, van Zyl LJ, Petrik LF, Trindade M (2019) Factors influencing pigment production by halophilic bacteria and its effect on brine evaporation rates. Microb Biotechnol 12:334–345. https://doi.org/10.1111/1751-7915.13319
Sims D, Sudbery I, Ilott NE et al (2014) Sequencing depth and coverage: key considerations in genomic analyses. Nat Rev Genet 15:121–132
Singh R, Dubey AK (2018) Diversity and applications of endophytic actinobacteria of plants in special and other ecological niches. Front Microbiol 9:1767
Singh V, Haque S, Singh H, Verma J, Vibha K, Singh R, Jawed A, Tripathi CK (2016) Isolation, screening, and identification of novel isolates of actinomycetes from India for antimicrobial applications. Front Microbiol 7:1921. https://doi.org/10.3389/fmicb.2016.01921
Siro G, Pipite A, Christi K, Srinivasan S, Subramani R (2022) Marine actinomycetes associated with stony corals: a potential hotspot for specialized metabolites. Microorganisms 10:1–32. https://doi.org/10.3390/microorganisms10071349
Strohl WR (2003) Antimicrobials. Microbial diversity and bioprospecting. ASM Press, Washington, pp 336–355. https://doi.org/10.1128/9781555817770.ch31
Subramani R, Aalbersberg W (2013) Culturable rare actinomycetes: diversity, isolation and marine natural product discovery. Appl Microbiol Biotechnol 97:9291–9321. https://doi.org/10.1007/s00253-013-5229-7
Subramani R, Sipkema D (2019) Marine rare actinomycetes: a promising source of structurally diverse and unique novel natural products. Mar Drugs 17(5):249
Sweetline C, Usha R, Palaniswamy M (2012) Antibacterial activity of actinomycetes from pichavaram mangrove of Tamilnadu. Appl J Hyg 1:15–18
Tao W, Yang A, Deng Z, Sun Y (2018) CRISPR/Cas9-based editing of Streptomyces for discovery, characterization, and production of natural products. Front Microbiol 9:1660
Thompson TP, Gilmore BF (2023) Exploring halophilic environments as a source of new antibiotics. Crit Rev Microbiol. https://doi.org/10.1080/1040841X.2023.2197491
Trabelsi I, Oves D, Manteca A, Genilloud O, Altalhi A, Nour M (2016) Antimicrobial activities of some actinomycetes isolated from different rhizospheric soils in Tunisia. CurrMicrobiol 73:220–227. https://doi.org/10.1007/s00284-016-1053-5
Undabarrena A, Beltrametti F, Claverías FP, González M, Moore ER, Seeger M, Cámara B (2016) Exploring the diversity and antimicrobial potential of marine actinobacteria from the comau fjord in Northern Patagonia, Chile. Front Microbiol 7:1–16. https://doi.org/10.3389/fmicb.2016.01135
Uritskiy G, DiRuggiero J (2019) Applying genome-resolved metagenomics to deconvolute the halophilic microbiome. Genes (basel) 10:220
Usha R, Ananthaselvi P, Venil CK, Palaniswamy M (2010) Antimicrobial and antiangiogenesis activity of streptomyces parvulusKUAP106 from mangrove soil. Europ J Biolog Sci 2:77–83
Valli S, Suvathi SS, Aysha OS, Nirmala P, Vinoth KP, Reena A (2012) Antimicrobial potential of Actinomycetes species isolated from marine environment. Asian Pac J Trop Biomed 2:469-73. https://doi.org/10.1016/S2221-1691(12)60078-1
Valliappan K, Sun W, Li Z (2014) Marine actinobacteria associated with marine organisms and their potentials in producing pharmaceutical natural products. Appl Microbiol Biotechnol 98:7365–7377. https://doi.org/10.1007/s00253-014-5954-6
van Bergeijk DA, Terlouw BR, Medema MH, van Wezel GP (2020) Ecology and genomics of actinobacteria: new concepts for natural product discovery. Nat Rev Microbiol 18:546–558
van Seventer JM, Hochberg NS (2016) Principles of infectious diseases: transmission, diagnosis, prevention, and control, 2nd edn. Elsevier
Van Seventer JM, Hochberg NS (2017) Principles of infectious diseases: transmission, diagnosis, prevention, and control. International encyclopedia of public health. Elsevier, pp 22–39
Venkatramanan M, Sankar Ganesh P, Senthil R, Akshay J, Veera Ravi A, Langeswaran K, Vadivelu J, Nagarajan S, Rajendran K, Shankar EM (2020) Inhibition of quorum sensing and biofilm formation in Chromobacterium violaceum by fruit extracts of Passiflora edulis. ACS Omega 5:25605–25616. https://doi.org/10.1021/acsomega.0c02483
Vera-Gargallo B, Ventosa A (2018) Metagenomic insights into the phylogenetic and metabolic diversity of the prokaryotic community dwelling in hypersaline soils from the Odiel Saltmarshes (SW Spain). Genes (basel) 9:152
Verma M, Lal D, Kaur J, Saxena A, Kaur J, Anand S, Lal R (2013) Phylogenetic analyses of phylum actinobacteria based on whole genome sequences. Res Microbiol 164:718–728. https://doi.org/10.1016/j.resmic.2013.04.002
Vignesh A, Ayswarya S, Gopikrishnan V, Radhakrishnan M (2019) Bioactive potential of actinobacteria isolated from the gut of marine fishes. Indian J Geomarine Sci 48:1280–1285
Vigneshwari J, Senthilkumar PK, Vijayakumar N, Gnanasekaran A, Dineshkumar K, Selvamani V, Dar KA (2022) Broad spectrum of bioactive compounds from halophilic actinomycetes isolated from the Kodiyakadu saltpan of Vedaranyam-India. Mater Today Proc 59:979–987. https://doi.org/10.1016/j.matpr.2022.02.141
Villanova V, Galasso C, Fiorini F, Lima S, Brönstrup M, Sansone C, Brunet C, Brucato A, Scargiali F (2021) Biological and chemical characterization of new isolated halophilic microorganisms from saltern ponds of Trapani, Sicily. Algal Res 54:102192. https://doi.org/10.1016/j.algal.2021.102192
Wahaab F, Subramaniam K (2018) Bioprospecting marine actinomycetes for multidrug-resistant pathogen control from Rameswaram coastal area, Tamil Nadu, India. Arch Microbiol 200:57–71
Ward AC, Allenby NE (2018) Genome mining for the search and discovery of bioactive compounds: the streptomyces paradigm. FEMS Microbiol Lett 365:1–20. https://doi.org/10.1093/femsle/fny240
Weber T, Kim HU (2016) The secondary metabolite bioinformatics portal: computational tools to facilitate synthetic biology of secondary metabolite production. Synth SystBiotechnol 1:69–79. https://doi.org/10.1016/j.synbio.2015.12.002
White JR, Nagarajan N, Pop M (2009) Statistical methods for detecting differentially abundant features in clinical metagenomic samples. PLoS Comput Biol 5:e1000352
World Health Organization (WHO) (2017) Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics; WHO: Geneva, Switzerland, 2017. Available online: http://www.who.int/medicines/publications/WHO-PPL-Short_Summary_25Feb-ET_NM_WHO.pdf. Accessed 20 Feb 2023
World Health Organization (WHO) (2021) Antimicrobial Resistance. https://www.who.int/news-room/fact-sheets/detail/antimicrobial-resistance. Accessed 25 Feb 2023
Wu Z, Xie L, Xia G, Zhang J, Nie Y, Hu J, Wang S, Zhang R (2005) A new tetrodotoxin-producing actinomycete, Nocardiopsis dassonvillei, isolated from the ovaries of puffer fish Fugu rubripes. Toxicon 45:851–859
Wu Z-C, Li S, Nam S-J et al (2013) Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037. J Nat Prod 76:694–701
Wyche TP, Hou Y, Vazquez-Rivera E, Braun D, Bugni TS (2012) Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp. J Nat Prod 75:735–740. https://doi.org/10.1021/np300016r
Xi L, Jisheng R, Ying H (2012) Diversity and biosynthetic potential of culturable actinomycetes associated with marine sponges in the China seas. Inter J Mol Sci 13:5917–5932
Xie Y, Xu H, Si S, Sun C, Chen R (2008) Sansanmycins B and C, new components of sansanmycins. J Antibiot (tokyo) 61:237–240. https://doi.org/10.1038/ja.2008.34
Xie CL, Xia JM, Wang JS, Lin DH, Yang XW (2018) Metabolomic Investigations on Nesterenkonia flava Revealed Significant Differences between Marine and Terrestrial Actinomycetes. Mar Drugs 16:356. https://doi.org/10.3390/md16100356
Xing K, Liu W, Zhang YJ, Bian GK, Zhang WD, Tamura T, Lee JS, Qin S, Jiang JH (2013) Amycolatopsis jiangsuensis sp. nov., a novel endophytic actinomycete isolated from a coastal plant in Jiangsu, China. Antonie Van Leeuwenhoek 103:433–439. https://doi.org/10.1007/s10482-012-9823-y
Xiong Z-Q, Wang J-F, Hao Y-Y, Wang Y (2013) Recent advances in the discovery and development of marine microbial natural products. Mar Drugs 11:700–717
Xu D-B, Ye W-W, Han Y, Deng Z-X, Hong K (2009) Natural products from mangrove actinomycetes. Mar Drugs 12:2590–2613
Yadav AN, Saxena AK (2018) Biodiversity and biotechnological applications of halophilic microbes for sustainable agriculture. J Appl Biol Biotechnol 6:48–55
Yamanaka K, Reynolds KA, Kersten RD, Ryan KS, Gonzalez DJ, Nizet V, Dorrestein PC, Moore BS (2014) Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A. Proc Natl Acad Sci U S A 111:1957–1962. https://doi.org/10.1073/pnas.1319584111
Zainal Abidin ZA, Abdul Malek N, Zainuddin Z, Chowdhury AJK (2015) Selective isolation and antagonistic activity of actinomycetes from mangrove forest of Pahang, Malaysia. Front Life Sci 9:24–31
Zaman SB, Hussain MA, Nye R, Mehta V, Mamun KT, Hossain N (2017) A review on antibiotic resistance: alarm bells are ringing. Cureus 9:e1403. https://doi.org/10.7759/cureus.1403
Zamora-Quintero AY, Torres-Beltrán M, Matus DG, Oroz-Parra I, Millán-Aguiñaga N (2022) Rare actinobacteria isolated from the hypersaline Ojo de Liebre Lagoon as a source of novel bioactive compounds with biotechnological potential. Microbiology 168:1–16. https://doi.org/10.1099/mic.0.001144
Zeng X, Alain K, Shao Z (2021) Microorganisms from deep-sea hydrothermal vents. Mar Life Sci Technol 3:204–230. https://doi.org/10.1007/s42995-020-00086-4
Zeng Y, Hong Y, Azi F, Liu Y, Chen Y, Guo C, Lin D, Wu Z, Chen W, Xu P (2022) Advanced genome-editing technologies enable rapid and large-scale generation of genetic variants for strain engineering and synthetic biology. Curr Opin Microbiol 69:102175
Zhang XY, He F, Wang GH, Bao J, Xu XY, Qi SH (2013) Diversity and antibacterial activity of culturable actinobacteria isolated from five species of the South China Sea gorgonian corals. World J Microbiol Biotechnol 29:1107–1116
Zheng Z, Zeng W, Huang Y, Yang Z, Li J, Cai H (2000) Detection of antitumor and antimicrobial activities in marine organism associated actinomycetes isolated from the Taiwan Strait, China. FEMS Microbiol Lett 188:87–91
Ziemert N, Lechner A, Wietz M, Millán-Aguiñaga N, Chavarria KL, Jensen PR (2014) Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora. Proc Natl Acad Sci U S A 111:E1130–E1139. https://doi.org/10.1073/pnas.1324161111
Ziemert N, Alanjary M, Weber T (2016) The evolution of genome mining in microbes–a review. Nat Prod Rep 33:988–1005. https://doi.org/10.1039/c6np00025h
Zotchev SB (2012) Marine actinomycetes as an emerging resource for the drug development pipelines. J Biotechnol 158:168–175. https://doi.org/10.1016/j.jbiotec.2011.06.002
Acknowledgements
The authors are thankful to the National Centre for Coastal Research (NCCR), MoES for the academic support. In addition, we acknowledge RUSA 2.0-Biological Sciences, Bharathidasan University and DST-FIST, Govt. of India, in Marine Science (SR/FST/ES-I/2019/62 (C)), Bharathidasan University, Tiruchirapalli-24 for the academic support.
Funding
No funding was received to assist with the preparation of this manuscript.
Author information
Authors and Affiliations
Contributions
AJR: conceptualization, validation, formal analysis, investigation, writing-original draft, writing-review & editing. HS and HUD: conceptualization, methodology. VTD: software, validation, formal analysis. VD: investigation, data curation, visualization, AJR and HS writing-original draft, SGM: writing-review & editing.
Corresponding authors
Ethics declarations
Conflict of interest
On behalf of all the authors, the corresponding author states that there is no conflict of interest.
Research involving human participants and/or animals
The authors declared that there is no human and/or animals’ participations are involved in this study.
Informed consent
Not applicable to the current review as we have not used any human or animal subject andall the authors of this article agree to the publication.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Rathinam, A.J., Santhaseelan, H., Dahms, HU. et al. Bioprospecting of unexplored halophilic actinobacteria against human infectious pathogens. 3 Biotech 13, 398 (2023). https://doi.org/10.1007/s13205-023-03812-8
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s13205-023-03812-8