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Effect of anti-resistance exercise intervention on sarcopenia in hemodialysis patients under nanofiber-based composite membrane

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Abstract

To explore the intervention effect of anti-resistance exercise on sarcopenia in hemodialysis patients, the polyvinyl alcohol/polyacrylonitrile nanofiber-based composite membrane (PVA/PAN TFNC) was prepared in this study under optimized conditions, which was compared with traditional polysulfone (PSf) membrane for dialysis performance test. Then, a controlled experiment was used in the hemodialysis treatment of 46 maintenance hemodialysis (MHD) patients with sarcopenia detected in Chengdu First People’s Hospital. The patients from the control group should have 12 weeks of regular exercise, while the intervention group received 12 weeks of anti-resistance exercise intervention. It was found that the optimized PVA/PAN TFNC membrane had good dialysis performance (urea clearance rate of 83.4%, lysozyme clearance rate of 47.6%, and bovine serum albumin (BSA) retention rate of 98.7%). After anti-resistance exercise intervention, there were statistically marked differences in physical activity status (maximum grip strength and daily pace), nutritional status (serum albumin), dialysis adequacy (Kt/V), and quality of life score between the intervention group and the control group (P < 0.05). In addition, the levels of inflammatory cytokines (interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-α) of the intervention group changed obviously before and after intervention, namely anti-resistance exercise intervention in dialysis could improve the micro-inflammatory state. In conclusion, the optimized PVA/PAN TFNC membrane had good dialysis performance. Anti-resistance exercise in dialysis could promote the physical status of MHD patients complicated with sarcopenia, improve the nutritional status, and reduce micro-inflammatory response, thus enhancing the quality of life of patients.

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Data availability statement

The data used to support the findings of this study are available from the corresponding author upon request.

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Acknowledgements

Subject of Science and Technology Department of Sichuan Province (No. 2019YFS0283).

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Authors and Affiliations

  1. Department of Nephrology, Chengdu First People’s Hospital, Chengdu, 610016, Sichuan Province, China

    Tingyu Chen, Guangyu Ao, Qiang Liu & Shulu Zhou

  2. Department of Radiology, Chengdu First People’s Hospital, Chengdu, 610016, Sichuan Province, China

    Liang Ye

  3. Department of Orthopedics, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, China

    Qinsheng Yu

  4. Department of Nephrotic Hemodialysis, Dongzhimen Hospital, Beijing University of Chinese Medicine, No. 5 Haiyuncang, Dongcheng District, Beijing, 100700, China

    Jian Zhong

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  1. Tingyu Chen
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  2. Liang Ye
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  5. Qiang Liu
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Correspondence to Jian Zhong.

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Chen, T., Ye, L., Yu, Q. et al. Effect of anti-resistance exercise intervention on sarcopenia in hemodialysis patients under nanofiber-based composite membrane. Appl Nanosci 13, 3599–3608 (2023). https://doi.org/10.1007/s13204-022-02740-y

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  • DOI: https://doi.org/10.1007/s13204-022-02740-y

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