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Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30

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Abstract

Lipid nanocarrier displays the advantages over conventional drug carriers as they are formulated with biodegradable and non-irritant lipids. However, the main drawbacks are the agglomeration of lipid particles, instability over storage, low drug loading, and the burst release of active ingredients. In this study, we investigated the effects of various polysorbate nonionic surfactants namely Tween 20, 40, 60, or 80 on the nanostructured lipid carrier (NLC). NLC incorporated with polysorbate nonionic surfactant was prepared by using high-pressure homogenization technique. The average size was reduced to 139.9 ± 15.8 nm in the presence of Tween 80 and remained stable in nano-size even incubated for 28 days. Encapsulation of l-ascorbic acid or Gold Tri.E 30 showed a high encapsulation efficiency of more than 75%, where the highest was Gold Tri.E in the presence of Tween 60 at 99.7%. In vitro release study showed that the release of both l-ascorbic acid and Gold Tri.E was significantly reduced in NLC with Tween as compared to bare active ingredients and NLC without Tween. In conclusion, the incorporation of Tween successfully produced a lipid nanocarrier that has the potential to be developed as a carrier of various active ingredients such as nutrients, extracts, and drugs.

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Acknowledgements

This work was fully supported by the University of Malaya Centre of Innovation & Commercialization (UMCIC), University of Malaya through Geran Prototaip (RU005U-2016), Prototype Research Grant Scheme (PRGS) PR002-2018A, and Fundamental Research Grant (GPF065B-2018). The authors would like to thanks Sime Darby Plantation Sdn. Bhd., Malaysia for sponsoring the Gold Tri.E 30 Powder, Dr. Noor Idayu Mat Zahid and Ms. Nurul Shahidah for allowing us to use the Malvern Zetasizer.

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  1. Colloid Laboratory, Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Vicit Rizal Eh Suk, Farhanim Mohd. Latif, Yin Yin Teo & Misni Misran

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  1. Vicit Rizal Eh Suk
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  2. Farhanim Mohd. Latif
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  3. Yin Yin Teo
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  4. Misni Misran
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Correspondence to Vicit Rizal Eh Suk.

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Eh Suk, V.R., Mohd. Latif, F., Teo, Y.Y. et al. Development of nanostructured lipid carrier (NLC) assisted with polysorbate nonionic surfactants as a carrier for l-ascorbic acid and Gold Tri.E 30. J Food Sci Technol 57, 3259–3266 (2020). https://doi.org/10.1007/s13197-020-04357-x

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  • DOI: https://doi.org/10.1007/s13197-020-04357-x

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