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Presentation and Spectrum of Male Breast Cancer in a Rural Cancer Center in a Subunit of Tata Memorial Center, India

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Abstract

This is a retrospective study of the incidence and clinical profile of male breast cancer (MBC) presenting to a rural cancer center in Punjab, India. All MBC cases registered over a period of 4.5 years from January 2015 to July 2019 were included. The study included 34 MBC patients accounting for 1.9% of all breast cancer cases with median age of 62.5 years. All patients were from Punjab except one, with majority from district Sangrur. Family history was present in 7 (20.6%) patients. Mean BMI (n = 23) was 24.8. The median duration of symptoms was 6 months (range 1–60 months). Main complaint was lump in 58.8% of patients followed by lump with ulceration (41.2%). All cases were mostly unilateral, left in 21 (61.8%) and right in 13 (38.2%), and one had bilateral breast cancer. Most tumors were centrally located (70.6%). Infiltrating ductal carcinoma and grade 3 were the commonest histology. ER positivity was high seen in 76.5% cases. In our study, 16 (47.1%) patients presented with distant metastasis at the time of diagnosis, and 10 (39.1%) were locally advance. Bone (41%) followed by lung (17%) were the most common sites of metastasis. Thirteen patients were treated radically, nine were treated with palliative intent, and twelve patients defaulted. Median follow-up period was 16.5 months. MBC constituted 1.9% of all breast cancers registered at our institute, which is higher than worldwide average. Our study population had a longer time to presentation, and majority were metastatic.

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References

  1. Giordano SH, Cohen DS, Buzdar AU, Perkins G, Hortobagyi GN (2004) Breast carcinoma in men: a population-based study. Cancer: Interdisc Int J Am Cancer Soc 101(1):51–57

    Article  Google Scholar 

  2. Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, Bartlett JM, Gelmon K, Nahleh Z, Bergh J, Cutuli B (2010) Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol 28(12):2114–2122

    Article  Google Scholar 

  3. Weiss JR, Moysich KB, Swede H (2005) Epidemiology of male breast cancer. Cancer Epidemiol Prev Biomark 14(1):20–26

    Google Scholar 

  4. Yousef AJ (2017) Male breast cancer: epidemiology and risk factors. Semin Oncol 44(4):267–272 WB Saunders

    Article  Google Scholar 

  5. American Cancer Society (2020) Key statistics for breast cancer in men

  6. Fentiman IS, Fourquet A, Hortobagyi GN (2006) Male breast cancer. Lancet 367(9510):595–604

    Article  Google Scholar 

  7. Jana BRP (2019) Chief Editor: John V Kiluk. https://emedicine.medscape.com/article/1954174-print

  8. Gómez-Raposo C, Tévar FZ, Moyano MS, Gómez ML, Casado E (2010) Male breast cancer. Cancer Treat Rev 36(6):451–457

    Article  Google Scholar 

  9. Reis LO, Dias FG, Castro MA, Ferreira U (2011) Male breast cancer. Aging Male 14(2):99–109

    Article  Google Scholar 

  10. Chavez-MacGregor M, Clarke CA, Lichtensztajn D, Hortobagyi GN, Giordano SH (2013) Male breast cancer according to tumor subtype and race: a population-based study. Cancer. 119(9):1611–1617

    Article  Google Scholar 

  11. Bloom KJ, Govil H, Gattuso P, Reddy V, Francescatti D (2001) Status of HER-2 in male and female breast carcinoma. Am J Surg 182(4):389–392

    Article  CAS  Google Scholar 

  12. Rudlowski C, Friedrichs N, Faridi A, Füzesi L, Moll R, Bastert G, Rath W, Büttner R (2004) Her-2/neu gene amplification and protein expression in primary male breast cancer. Breast Cancer Res Treat 84(3):215–223

    Article  CAS  Google Scholar 

  13. Ewertz M, Holmberg L, Tretli S, Pedersen BV, Kristensen A (2001) Risk factors for male breast cancer? A case-control study from Scandinavia. Acta Oncol 40(4):467–471

    Article  CAS  Google Scholar 

  14. Palmer JR, Rao RS, Adams-Campbell LL, Rosenberg L (2001) Height and breast cancer risk: results from the Black Women’s Health Study (United States). Cancer Causes Control 12(4):343–348

    Article  CAS  Google Scholar 

  15. Hsing AW, Devesa SS (2001) Trends and patterns of prostate cancer: what do they suggest? Epidemiol Rev 23(1):3–13

    Article  CAS  Google Scholar 

  16. Lawlor DA, Okasha M, Gunnell D, Smith GD, Ebrahim S (2003) Associations of adult measures of childhood growth with breast cancer: findings from the British Women’s Heart and Health Study. Br J Cancer 89(1):81–87

    Article  CAS  Google Scholar 

  17. Okasha M, McCarron P, Gunnell D, Smith GD (2003) Exposures in childhood, adolescence and early adulthood and breast cancer risk: a systematic review of the literature. Breast Cancer Res Treat 78(2):223–276

    Article  CAS  Google Scholar 

  18. Ritte R, Lukanova A, Tjønneland A, Olsen A, Overvad K, Mesrine S, Fagherazzi G, Dossus L, Teucher B, Steindorf K, Boeing H (2013) Height, age at menarche and risk of hormone receptor-positive and-negative breast cancer: a cohort study. Int J Cancer 132(11):2619–2629

    Article  CAS  Google Scholar 

  19. Demers PA, Thomas DB, Rosenblatt KA, Jimenez LM, McTiernan A, Stalsberg H, Stemhagen A, Thompson WD, Curnen MG, Satariano W, Austin DF (1991) Occupational exposure to electromagnetic fields and breast cancer in men. Am J Epidemiol 134(4):340–347

    Article  CAS  Google Scholar 

  20. Ottini L, Rizzolo P, Zanna I, Falchetti M, Masala G, Ceccarelli K, Vezzosi V, Gulino A, Giannini G, Bianchi S, Sera F, Palli D (2009) BRCA1/BRCA2 mutation status and clinical-pathologic features of 108 male breast cancer cases from Tuscany: a population-based study in Central Italy. Breast Cancer Res Treat 116(3):577–586. https://doi.org/10.1007/s10549-008-0194-z

    Article  PubMed  Google Scholar 

  21. Thakur JS, Budukh A, Kapoor R, Malhotra P, Bashar MA, Kathirvel S, Dixit R, Arora P, Bhatia SP, Badwe RA (2017) Urban–rural differences in cancer incidence and pattern in Punjab and Chandigarh: findings from four new population-based cancer registries in North India. Int J Noncommun Dis 2(2):49

    Google Scholar 

  22. Chikaraddi SB, Krishnappa R, Deshmane V (2012) Male breast cancer in Indian patients: is it the same? Indian J Cancer 49(3):272–276

    Article  CAS  Google Scholar 

  23. Rai B, Ghoshal S, Sharma SC (2005) Breast cancer in males: a PGIMER experience. J Cancer Res Ther 1(1):31–33

    Article  Google Scholar 

  24. Sundriyal D, Kotwal S, Dawar R, Parthasarathy KM (2015) Male breast cancer in India: series from a cancer research centre. Indian J Surg Oncol 6(4):384–386

    Article  Google Scholar 

  25. Shah P, Robbani I, Shah O (2009) Clinicopathological study of male breast carcinoma: 24 years of experience. Ann Saudi Med 29(4):288–293

    Article  Google Scholar 

  26. Chhabra MK, Kadyaprath G, Srivastva A, Selvakumar V, Ranjan P, Durga CK, Thomas S, Kaur N, Singh M, Govil M, Gupta A (2019) Male breast cancer—an Indian multicenter series of 106 cases. Indian J Surg 9:1–8

    Google Scholar 

  27. Ram D, Rajappa SK, Selvakumar VP, Shukla H, Goel A, Kumar R, Kumar K (2017) Male breast cancer: a retrospective review of clinical profile from a tertiary cancer care center of India. South Asian J Cancer 6(4):141–143

    Article  Google Scholar 

  28. Gogia A, Raina V, Deo SV, Shukla NK, Mohanti BK (2015) Male breast cancer: a single institute experience. Indian J Cancer 52(4):526–529

    Article  CAS  Google Scholar 

  29. Patel R, Kumar R, Pandya SJ, Mendiratta P (2016) Male breast Cancer: single institutional experience at Gujarat cancer & research institute. Int J Curr Adv Res 5:1203–1204

    Google Scholar 

  30. Mukherjee A, Saha A, Chattopadhyay S, Sur PK. A tertiary oncology centre in India

  31. Ying MW, Agrawal A, Cheung KL (2005) The ‘other half’ of breast cancer: a review of male breast cancer. J Men's Health Gend 2(4):406–413

    Article  Google Scholar 

  32. Rosenblatt KA, Thomas DB, McTiernan A, Austin MA, Stalsberg H, Stemhagen A, Thompson WD, Curnen MG, Satariano W, Austin DF, Isacson P (1991) Breast cancer in men: aspects of familial aggregation. JNCI: J Natl Cancer Instit 83(12):849–854

    Article  CAS  Google Scholar 

  33. Contractor KB, Kaur K, Rodrigues GS, Kulkarni DM, Singhal H (2008) Male breast cancer: is the scenario changing. World J Surg Oncol 6(1):1–1

    Article  Google Scholar 

  34. Mitra D, Manna A, Sikdar SK, Sur PK (2007) Clinicopathological study and its prognostic implication in male breast carcinoma. J Indian Med Assoc 105(12):681–3, 686

    PubMed  Google Scholar 

  35. Al-Naggar RA, Al-Naggar DH (2012) Perceptions and opinions about male breast cancer and male breast self-examination: a qualitative study. Asian Pac J Cancer Prev 13(1):243–246

    Article  Google Scholar 

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Authors and Affiliations

  1. Surgical Oncology, Homi Bhabha Cancer Hospital, Mehal Mubarak Colony, inside Civil Hospital Campus, Sangrur, Punjab, 148001, India

    Sachin Khandelwal, Rakesh Sharma & Debashish Chaudhary

  2. Radiation Oncology, Homi Bhabha Cancer Hospital, Sangrur, Punjab, India

    Priyanka Goel, Tapas Dora & Rakesh Kapoor

  3. Pathology, Homi Bhabha Cancer Hospital, Sangrur, Punjab, India

    Sankalp Sancheti

  4. Medical Oncology, Homi Bhabha Cancer Hospital, Sangrur, Punjab, India

    Alok Goel

  5. Early Detection Programme, Homi Bhabha Cancer Hospital, Sangrur, Punjab, India

    Nirmaljot Kaur

Authors
  1. Sachin Khandelwal
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  2. Priyanka Goel
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  4. Sankalp Sancheti
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  5. Debashish Chaudhary
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All authors have contributed significantly to the paper and are in agreement with the content of the manuscript.

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The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.

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Correspondence to Debashish Chaudhary.

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Khandelwal, S., Goel, P., Sharma, R. et al. Presentation and Spectrum of Male Breast Cancer in a Rural Cancer Center in a Subunit of Tata Memorial Center, India. Indian J Surg Oncol 12, 330–334 (2021). https://doi.org/10.1007/s13193-021-01306-8

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  • DOI: https://doi.org/10.1007/s13193-021-01306-8

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