Abstract
Breast cancer in association with type- 1 neurofibromatosis (NF1) is a rare clinical entity. Here, we present the case of a 45-year-old woman with typical clinical manifestations of NF1, who presented with a right breast lump, which she had first noticed 8 months back but had disregarded, believing it to be another manifestation of her Von Recklinghausen’s disease. Clinical examination and diagnostic workup were suggestive of a breast carcinoma. Subsequently, she underwent modified radical mastectomy, followed by postoperative chemotherapy. Histopathological examination revealed high grade invasive duct carcinoma and multiple neurofibromas. After 7.5 months, she developed recurrence at the drain site with pulmonary and bony metastasis and died 9 months after surgery. Delayed presentation of the patient was the result of her mistaken identification for the breast tumor as a manifestation of NF-1. Early onset, high grade tumor and early recurrence with metastasis place strong emphasis on clinical alertness and to opt for an aggressive treatment option.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Kumar K, Abbas AK, Fausto N. Neoplasia.In: Robbins and Cotran Pathologic Basis of Disease.7th Ed.Philadelphia: WB Saunders.2004; 305
Walker L, Thomson D, Easton D et al (2006) A prospective study of Neurofibromatosis type1 cancer incidence in the UK. Br J Cancer 195:233–238
Roberta I, Barbara M, Graziella P (2008) Association of GIST, breast cancer and Schwannoma in a 60- year old woman affected by type-1 von Recklinghausen’s neurofibromatosis. Tumori 194:126–128
Zoller ME, Rembeck B, Oden A, Samuelsson M, Angervall L (1997) Malignant and benign tumors in patients with neurofibromatosis type 1 in a defined Swedish population. Cancer 79:2125–2131
Ceccaroni M, Genuardi M, Legge F, Lucci-Cordisco E, Carrara S, D’Amico F et al (2002) BRCA1-related malignancies in a family presenting with von Recklinghausen’s disease. Gynecol Oncol 86:375–378
Murayama Y, Yamamoto Y, Shimojima N, Takahara T, Kikuchi K, Iida S et al (1999) T1 breast cancer associated with von Recklinghausen’s neurofibromatosis. Breast Cancer 6:227–230
Nakamura M, Tangoku A, Kusanagi H, Oka M, Suzuki T (1998) Breast cancer associated with Recklinghausen’s disease: report of a case. Nippon Geka Hokan 67:3–9
Veronesi A, de Giacomi C, Magri MD, Lombardi D, Zanetti M, Scuderi C et al (2005) Familial breast cancer: characteristics and outcome of BRCA 1–2 positive and negative cases. BMC Cancer 5:70
Sharif S, Moran A, Huson SM, Iddenden R, Shenton A, Howard E et al (2007) Women with neurofibromatosis 1 are at a moderately increased risk of developing breast cancer and should be considered for early screening. J Med Genet 44:481–484
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Kumar, N., Pandey, A.N., Kumari, S. et al. Breast Cancer Associated with Von Recklinghausen's Disease: Case Report and Review of Literature. Indian J Surg Oncol 5, 205–207 (2014). https://doi.org/10.1007/s13193-014-0327-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13193-014-0327-2