Skip to main content
SpringerLink
Log in

Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer

  • Interesting Image
  • Published:
Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Three males aged 71 to 80 years with known stage IV metastatic prostate cancer underwent F-18 sodium fluoride (NaF) PET/CT to assess osseous metastatic disease burden and stability. In addition to F-18 NaF avid known osseous metastases, each patient also exhibited increased F-18 NaF activity in soft tissues. The first patient exhibited multiple F-18 NaF avid enlarged retroperitoneal and pelvic lymph nodes on consecutive PET/CT scans. The second patient demonstrated an F-18 NaF avid thyroid nodule on consecutive PET/CT scans. The third patient exhibited increased F-18 NaF activity in a hepatic metastasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Segall G, Delbeke D, Stabin MG, Even-Sapir E, Fair J, Sajdak R, et al. SNM practice guideline for sodium 18F-fluoride PET/CT bone scans 1.0. J Nucl Med. 2010;51:1813–20.

    Article  PubMed  Google Scholar 

  2. Sabbah N, Jackson T, Mosci C, Jamali M, Minamimoto R, Quon A, et al. 18F-sodium fluoride PET/CT in oncology: an atlas of SUV’s. Clin Nucl Med. 2015;40:e228–31.

    Article  PubMed  Google Scholar 

  3. Sheth S, Colletti PM. Atlas of sodium fluoride PET bone scans: atlas of NaF PET bone scans. Clin Nucl Med. 2012;37:e110–6.

    Article  PubMed  Google Scholar 

  4. Dweck MR, Chow MW, Joshi NV, Williams MC, Jones C, Fletcher AM, et al. Coronary arterial 18F-sodium fluoride uptake: a novel marker of plaque biology. J Am Coll Cardiol. 2012;59:1539–48.

    Article  CAS  PubMed  Google Scholar 

  5. Yoon DY, Chang SK, Choi CS, Yun EJ, Seo YL, Nam ES, et al. The prevalence and significance of incidental thyroid nodules identified on computed tomography. J Comput Assist Tomogr. 2008;32:810–5.

    Article  PubMed  Google Scholar 

  6. Shie P, Cardarelli R, Sprawls K, Fulda KG, Taur A. Systematic review: prevalence of malignant incidental thyroid nodules identified on fluorine-18 fluorodeoxyglucose positron emission tomography. Nucl Med Commun. 2009;30:742–8.

    Article  PubMed  Google Scholar 

  7. Chun AR, Jo HM, Lee SH, Chun HW, Park JM, Kim KJ, et al. Risk of malignancy in thyroid incidentalomas identified by fluorodeoxyglucose-positron emission tomography. Endocrinol Metab (Seoul). 2015;30:71–7.

    Article  Google Scholar 

  8. Basu S, Kembhavi S. Serendipitous observation of hepatic metastases on (18)F-fluoride PET in a patient with infiltrating ductal carcinoma of breast: correlation with contrast enhanced CT. Clin Nucl Med. 2012;37:1176–8.

    PubMed  Google Scholar 

  9. Swietaszczyk C, Prasad V, Baum RP. Intense 18F-fluoride accumulation in liver metastases from a neuroendocrine tumor after peptide receptor radionuclide therapy. Clin Nucl Med. 2012;37:e82–3.

    Article  PubMed  Google Scholar 

  10. Wong KK, Piert M. Dynamic bone imaging with 99mTc-labeled diphosphonates and 18F-NaF: mechanisms and applications. J Nucl Med. 2013;54:590–9.

    Article  CAS  PubMed  Google Scholar 

  11. Cook GJ, Fogelman I. The role of positron emission tomography in skeletal disease. Semin Nucl Med. 2001;31:50–61.

    Article  CAS  PubMed  Google Scholar 

  12. Hawkins RA, Choi Y, Huang SC, Hoh CK, Dahlbom M, Schiepers C, et al. Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET. J Nucl Med. 1992;33:633–42.

    CAS  PubMed  Google Scholar 

  13. Kurdziel KA, Shih JH, Apolo AB, Lindenberg L, Mena E, McKinney YY, et al. The kinetics and reproducibility of 18F-sodium fluoride for oncology using current PET camera technology. J Nucl Med. 2012;53:1175–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Valdes-Martinez A, Kraft SL, Brundage CM, Arceneaux BK, Stewart JA, Gibbons DS. Assessment of blood pool, soft tissue, and skeletal uptake of sodium fluoride F 18 with positron emission tomography-computed tomography in four clinically normal dogs. Am J Vet Res. 2012;73:1589–95.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Nuclear Medicine, Department of Radiology, Duke University Medical Center, 2301 Erwin Rd, Box 3949, Durham, NC, 27710, USA

    Andrew S. Hawkins & Brandon A. Howard

Authors
  1. Andrew S. Hawkins
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Brandon A. Howard
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Brandon A. Howard.

Ethics declarations

Conflict of Interest

Andrew Hawkins and Brandon Howard declare that they have no conflict of interest relevant to the work described herein.

Ethical Statement

This report of three patients did not constitute human subjects research according to the standards of the Duke Institutional Review Board (IRB) (https://irb.duhs.duke.edu/policies-and-regulations/policies) and was exempt from IRB review.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hawkins, A.S., Howard, B.A. Unusual Soft Tissue Uptake of F-18 Sodium Fluoride in Three Patients Undergoing F-18 NaF PET/CT Bone Scans for Prostate Cancer. Nucl Med Mol Imaging 51, 274–276 (2017). https://doi.org/10.1007/s13139-016-0420-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13139-016-0420-2

Keywords

Search

Navigation