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Primary classic Kaposi sarcoma of the thigh

  • Case Report
  • Published:
Hellenic Journal of Surgery

Abstract

Background

Classic-sporadic Kaposi’s sarcoma is a clinical variant of the broad spectrum of Kaposi’s sarcoma, and represents an angioproliferative rare disorder whose development is caused by human herpesvirus 8 (HHV-8) infection; also known as Kaposi’s sarcoma-associated herpesvirus (KSHV). The tumour appears to have an indolent course and good prognosis.

Case Report

Herein, we present the rare case of a 90-year-old Greek woman who presented with a 5-month history of a painful indurated area in the lower inner half of her left thigh, covered with multiple red, brown and bluish plaques and nodules. Symptoms were not specific of the disease. Excisional biopsy of a lesion confirmed Kaposi’s sarcoma. Due to extensive disease, the patient was offered radiotherapy as apposite treatment. Three months later, the lesion displayed a remarkable remission.

Conclusions

Treatment for classic Kaposi’s sarcoma is not standard; it should be tailored to each individual case. Radiotherapy seems to offer the best treatment option for locally advanced symptomatic disease, while surgery may be of benefit to solitary or small superficial lesions. Despite the rarity of this tumour, surgeons, oncologists, and dermatologists need to be very suspicious when faced with such unusual lesions on the extremities.

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References

  1. Kaposi M. Idiopathisches multiples Pigmentsarkom der Haut. Arch Dermatol Syph 1872; 3:265–273

    Article  Google Scholar 

  2. Dupin N, Grandadam M, Calvez V, Gorin I, Aubin JT, Havard S. Herpesvirus-like DNA sequences in patients with Mediterranean Kaposi’s sarcoma. Lancet 1995; 345:761–762

    Article  CAS  PubMed  Google Scholar 

  3. Strichman-Almashanu L, Weltfriend S, Gideoni O, Friedman-Birnbaum R, Pollack S. No significant association between HLA antigens and classic Kaposi sarcoma: molecular analysis of 49 Jewish patients. J Clin Immunol 1995; 15:205–209

    Article  CAS  PubMed  Google Scholar 

  4. Sanders C, Marijke R, Canninga-van Dijk, Borleffs J. Kaposi’s sarcoma. Lancet 2004; 364:1549–1552

    Article  PubMed  Google Scholar 

  5. Takizawa C, Cestari S, Petri V, Nishio C, Nishio P. Lymphatic study of lower limbs in epidemic, classic and iatrogenic Kaposi sarcoma. Proceedings of the 11th International on AIDS. 1996; 7–12:168

    Google Scholar 

  6. Safai B, Good RA. Kaposi’s sarcoma: a review and recent developments. Clin Bull 1980; 10:62–69

    CAS  PubMed  Google Scholar 

  7. Zurrida S, Bartoli C, Nolé F, Agresti R, Del Prato I, Colleoni M, et al. Classic Kaposi’s sarcoma: a review of 90 cases. J Dermatol 1992; 19:548

    CAS  PubMed  Google Scholar 

  8. Reynolds WA, Winkelmann RK, Soule EH. Kaposi’s sarcoma: a clinicopathologic study with particular reference to its relationship to the reticuloendothelial system. Medicine (Baltimore) 1965; 44:419–443

    Article  CAS  Google Scholar 

  9. Zhang M, Bachmann S, Hemmer C, van Luzen J, von Stemm A, Dietrich R. Origin of Kaposi’s sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. Am J Pathol 1994; 144:51–59

    CAS  PubMed Central  PubMed  Google Scholar 

  10. Stein ME, Kantor A, Spencer D, Bezwoda WR. Classical Kaposi’s sarcoma in Caucasians in Africa — experience at the Johannesburg Hospital (1978–1992). Dermatology 1994; 188:182–187

    Article  CAS  PubMed  Google Scholar 

  11. Tappero JW, Conant MA, Wolfe SF, Berger TG. Kaposi’s sarcoma. Epidemiology, pathogenesis, histology, clinical spectrum, staging criteria and therapy. J Am Acad Dermatol 1993; 28:371–395

    Article  CAS  PubMed  Google Scholar 

  12. Iscovich J, Boffetta P, Franceschi S, Azizi E, Sarid R. Classic Kaposi Sarcoma. Epidemiology and Risk Factors Cancer 2000; 88:500–517

    CAS  Google Scholar 

  13. Berg JW. The incidence of multiple primary cancers. I. Development of further cancers in patients with lymphomas, leukemias, and myeloma. J Natl Cancer Inst 1967; 38:741–752

    CAS  PubMed  Google Scholar 

  14. Kosmidis C, Efthimiadis C, Anthimidis G, Karayannopoulou G, Grigoriou M, Vassiliadou K, et al. Kaposi’s sarcoma of the hand mimicking squamous cell carcinoma in a woman with no evidence of HIV infection: a case report. J Med Case Rep 2008; 2:213

    Article  PubMed Central  PubMed  Google Scholar 

  15. Billingham R. A rare case of Kaposi Sarcoma. J Lympoedema 2007; 2

    Google Scholar 

  16. Brenner B, Rakowsky E, Katz A, Gutman H, Sulkes A, Schacter J, et al. Tailoring treatment for classical Kaposis sarcoma: comprehensive clinical guidelines. Int J Oncol 1999; 14:1097–1102.

    CAS  PubMed  Google Scholar 

  17. Antman K, Chang Y. Kaposi sarcoma. N Engl J Med 2000; 342:1027–1038

    Article  CAS  PubMed  Google Scholar 

  18. Hengge U, Ruzicka T, Tyring S, Stuschke M, Roggendorf M, Schwartz R, et al. Update on Kaposi’s sarcoma and other HHV8 associated diseases. Part 1: epidemiology, environmental predispositions, clinical manifestations, and therapy. The LANCET Infectious Diseases 2002; 2:281–292

    Article  PubMed  Google Scholar 

  19. Chang Y, Cesarman E, Pessin MS, Pessin MS, Lee F, Culpepper J, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science 1994; 266:1865–1869

    Article  CAS  PubMed  Google Scholar 

  20. Brown E, Whitby D, Vitale F, Marshall V, Mbisa G, Gamache C, et al. Hematologic, and Immunologic Risk Factors for Classic Kaposi Sarcoma. Cancer 2006; 107:2282–2290

    Article  CAS  PubMed  Google Scholar 

  21. Piette WW. The incidence of second malignancies in subsets of Kaposi’s sarcoma. J Am Acad Dermatol 1987; 16:855–861

    Article  CAS  PubMed  Google Scholar 

  22. Goedert J, Vitale F, Lauria C, Serraino D, Montella M, Messina A, et al, and The Classical Kaposi’s Sarcoma Working Group. Risk Factors for Classical Kaposi’s Sarcoma. J Natl Cancer Inst 94:1712–1718

  23. Anderson A, Lauria C, Romano N, Brown E, Whitby D, Graubard A, et al. Risk factors for classical Kaposi sarcoma in a population -based case-control study in Sicily. Cancer Epidemiol Biomarkers Prev 2008; 17:3435–3443

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  24. Brambilla L, Boneschi V, Taglioni M, Ferrucci S. Staging of classic Kaposi’s sarcoma: a useful tool for therapeutic choices. Eur J Dermatol 2003; 13:83–86

    PubMed  Google Scholar 

  25. Wayne Grayson, Liron Pantanowitz. Histological variants of cutaneous Kaposi sarcoma. Diagnostic Pathology 2008; 3:31

    Article  Google Scholar 

  26. Chor PJ, Santa Cruz DJ. Kaposi’s sarcoma. A clinicopathologic review and differential diagnosis. J Cutan Pathol 1992; 19:6–20

    Article  CAS  PubMed  Google Scholar 

  27. Larralde M, Gonzalez V, Marietti R, Nussembaum D, Peirano M, Schroh R. Pseudo-Kaposi sarcoma with arteriovenous malformation. Pediatr Dermatol 2001; 18:325–327

    Article  CAS  PubMed  Google Scholar 

  28. Giuseppe Di Lorenzo. Update on classic Kaposi sarcoma therapy: New look at an old Disease. Critical Reviews in Oncology/Hematology 2008; 68:242–249

    Article  PubMed  Google Scholar 

  29. Nisce Z, Safai B, Poussin-Rosillo H. Once weekly total and subtotal skin electron beam therapy for Kaposi’s sarcoma. Cancer 1981; 47:640–644

    Article  CAS  PubMed  Google Scholar 

  30. Caccialanza M, Marca S, Piccinno R, Eulisse G. Radiotherapy of classic and human immunodeficiency virus-related Kaposi’s sarcoma: results in 1482 lesions. J Eur Acad Dermatol Venereol 2008; 22:297

    Article  CAS  PubMed  Google Scholar 

  31. Solan AJ, Greenwald ES, Silvay O. Long-te rm complete remissions of Kaposi’s sarcoma with vinblastine therapy. Cancer 1981; 47:637–639

    Article  CAS  PubMed  Google Scholar 

  32. Di Lorenzo G, Kreuter A, Di Trolio R, Guarini A, Romano C, Montesarchio V, et al. Activity and safety of pegylated liposomal doxorubicin as first-line therapy in the treatment of non-visceral classic Kaposi’s sarcoma: a multicenter study. J Invest Dermatol 2008; 128:1578–1580

    Article  PubMed  Google Scholar 

  33. Northfelt W, Dezube J, Thommes A, Miller J, Fischl A, Friedman-Kien A, et al. Pegylated-liposomal doxorubicin versus doxorubicin, bleomycin, and vincristine in the treatment of AIDS-related Kaposi’s sarcoma: results of a randomized phase III clinical trial. J Clin Oncol 1998; 16:2445–2451

    CAS  PubMed  Google Scholar 

  34. Boudreaux A, Smith L, Cosby D, Bason M, Tappero W, Berger G. Intralesional vinblastine for cutaneous Kaposi’s sarcoma associate with acquired immunodeficiency syndrome. A clinical trial to evaluate efficacy and discomfort associated with infection. J Am Acad Dermatol 1993; 28:61–65

    Article  CAS  PubMed  Google Scholar 

  35. Odom RB, Goette DK. Treatment of cutane ous Kaposi’s sarcoma with intralesional vincristine. Arch Dermatol 1978; 114:1693–1694

    Article  CAS  PubMed  Google Scholar 

  36. Tur E, Brenner S. Classic Kaposi’s sarcoma: low-dose interferon alfa treatment. Dermatology 1998; 197:37–42

    Article  CAS  PubMed  Google Scholar 

  37. Krown SE. Management of Kaposi sarcoma: the role of interferon and thalidomide. Curr Opin Oncol 2001; 13:374–381

    Article  CAS  PubMed  Google Scholar 

  38. Chelouche D, Abeid A, Merimsky O, Isakov J, Kollander Y, Meller Y, et al. Isolated limb perfusion with high-dose tumor necrosis factor and melphalan for Kaposi Sarcoma. Arch Surg 1999; 134:177–180

    Article  Google Scholar 

  39. Walmsley S, Northfelt W, Melosky B, Conant M, Friedman-Kien AE, Wagner B. Treatment of AIDS related cutaneous Kaposi’s sarcoma with topical alitretinoin (9-cis-retinoic acid) gel. Panretin Gel North American Study Group. J Acquir Immune Defic Syndr 1999; 22:235–465

    Article  CAS  PubMed  Google Scholar 

  40. Miles A, Dezube J, Lee Y, Krown E, Fletcher A, Saville W, et al. AIDS Malignancy Consortium. Antitumor activity of oral 9-cis-retinoic acid in HIV-associated Kaposi’s sarcoma. AIDS 2002; 16:421–429

    Article  CAS  PubMed  Google Scholar 

  41. Kedes DH, Ganem D. Sensitivity of Kaposi’s sarcoma associated herpesvirus replication to antiviral drugs. Implications for potential therapy. J Clin Invest 1997; 99:2082–2086

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Correspondence to N. G. Kelessis.

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Kelessis, N.G., Kritselis, G.D., Grigoriadis, K.D. et al. Primary classic Kaposi sarcoma of the thigh. Hellenic J Surg 86, 88–94 (2014). https://doi.org/10.1007/s13126-014-0103-3

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  • DOI: https://doi.org/10.1007/s13126-014-0103-3

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