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Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats

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Abstract

The present study examined the effect of water extract (200 mg/kg body weight) of Rosmarinus officinalis L. in streptozotocin (STZ)-induced diabetic rats for 21 days. The hepatoprotective effects were investigated in the liver tissues sections. There was a significant increase in serum liver biochemical parameters (aspartate aminotransferase, alanine transaminase, and alkaline phosphatase), accompanied by a significant decrease in the level of total protein and albumin in the STZ-induced rats when compared with that of the normal group. The high-dose treatment group (200 mg/kg body wt) significantly restored the elevated liver function enzymes near to normal. This study revealed that rosemary extracts exerted a hepatoprotective effect. The results indicate that the extract exhibits the protective effect on tissues and prove its potentials as an antidiabetic agent.

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References

  1. Alshawsh MA, Abdulla MA, Ismail S, Amin ZA (2011) Hepatoprotective effects of Orthosiphon stamineus extract on thioacetamide-induced liver cirrhosis in rats. Evid Based Complement Alternat Med 2011:1–6

    Article  Google Scholar 

  2. Bakirel T, Bakirel U, Keles OU, Ulgen SG, Yardibi H (2008) In vivo assessment of antidiabetic and antioxidant activities of rosemary (Rosmarinus officinalis) in alloxan-diabetic rabbits. J Ethnopharmacol 116:64–73

    Article  PubMed  Google Scholar 

  3. DE Sousa E, Zanatta L, Seifriz I, Creczynski-Pasa TB, Pizzolatti MG, Szpoganicz B, Silva FR (2004) Hypoglycemic effect and antioxidant potential of kaempferol-3, 7-O-(α)-dirhammoside from Bauhinia for cata leaves. J Natl Prod 67:829–832

    Article  CAS  Google Scholar 

  4. EL-Demerdash FM, Yousef MI, EL-Naga NI (2005) Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats. Food Chem Toxicol 43:57–63

    Article  PubMed  CAS  Google Scholar 

  5. Huseini HF, Larijani B, Heshmat R, Fakhrzadeh H, Radjabipour B, Toliat T, Raza M (2006) The efficacy of Silybum mariamam (L) Gaerth. (Silymarin) in the treatment of type II diabetes: a randomized, double-blind, place bo-controlled, clinical trial. Phytother Res 20:1036–1039

    Article  PubMed  CAS  Google Scholar 

  6. Jasmine R, Daisy P (2007) Hypoglycemic and hepatoprotective activity of Eugenia jambolana in streptozotocin-diabetic rats. Int J Biol Chem 1(2):117–121

    Article  Google Scholar 

  7. Kunt T, Forst T, Pfutzner A, Beyer J, Wahren J (1999) The physiological impact of proinsulin C-peptide. Pathophysiology 5:257–262

    Article  CAS  Google Scholar 

  8. Lee HJ, Cho HS, Seung EP, Lee SY, Kim CS, Kim DK et al (2008) Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology 250:109–115

    Article  PubMed  CAS  Google Scholar 

  9. Madani H, Talebolhosseini M, Asgary S, Naderi GH (2008) Hepatoprotective activity of Silybum marianum and Cichorium intybus against thioacetamide in rat. Pak J Nutr 7:172–176

    Article  CAS  Google Scholar 

  10. Makino T, Onot LN, Nakamura T, Muso E, Honda G (2002) Suppressive effects of rosmarinic acid on Mesangio proliferative glomerulonephritis in rats. Nephron 92:898–904

    Article  PubMed  CAS  Google Scholar 

  11. Mallick C, Chatterjee K, Guhabiswas M, Ghosh D (2007) Antihyperglycemic effects of separate and composite extract of root of Musa paradisiaca and leaf of Coccinia indica in streptozotocin induced diabetic male albino rat. Afr J Trad CAM 4:362–371

    Google Scholar 

  12. Nelson LD, Cox MM (2004) Lehninger’s principles of biochemistry, 4th edn. WH Freeman, New York

    Google Scholar 

  13. Siddiq O, Sun Y, Lin JC, Chien YW (1987) Facilitated transdermal transport of insulin. J Pharm Sci 76:341–345

    Article  Google Scholar 

  14. Tavafi MH, Ahmadvand AK, Tamjidipoor A (2011) Rosmarinic acid ameliorates diabetic nephropathy in uninephrectomized diabetic rats. Iran J Basic Med Sci 14(3):275–283

    CAS  Google Scholar 

  15. Tursun A, Astumi N, Hiroyuki M, Akio I, Toshitaka N (2007) A natural scavenger of peroxynitrites, protects against impairment of memory induced by Ab25-35. Behav Brain Res 180:139–145

    Article  Google Scholar 

  16. Valiathan MS (1998) Healing plants. Curr Sci 75:1122–1126

    Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Girls Science, King Abdulaziz University, Jeddah, Saudi Arabia

    Kholoud S. Ramadan, Enas N. Danial, Hanan S. Alnahdi & Najla O. Ayaz

  2. Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt

    Kholoud S. Ramadan

  3. Clinical Biochemistry Department, Faculty of Medicine, El-Azher University, Cairo, Egypt

    Olfat A. Khalil

  4. Chemistry of Natural and Microbial Products Department, National Research Center, El-Behooth Street, Dokki, Cairo, Egypt

    Enas N. Danial

Authors
  1. Kholoud S. Ramadan
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  2. Olfat A. Khalil
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  3. Enas N. Danial
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  4. Hanan S. Alnahdi
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  5. Najla O. Ayaz
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Correspondence to Kholoud S. Ramadan.

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Ramadan, K.S., Khalil, O.A., Danial, E.N. et al. Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. J Physiol Biochem 69, 779–783 (2013). https://doi.org/10.1007/s13105-013-0253-8

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  • DOI: https://doi.org/10.1007/s13105-013-0253-8

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