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The Effect of the ABCB1(MDR-1) C3435T Polymorphism in Turkish Patients with Aspirin Resistance in Acute Ischemic Stroke

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Abstract

Recurrence of thrombotic events during aspirin therapy is known as aspirin resistance (AR). This study aimed to investigate the rate of AR, the factors influencing AR in patients with acute ischemic stroke under regular aspirin use, and the relationship between AR and ABCB1 (MDR-1) C3435T (rs1045642) polymorphism. Throughout this multicenter prospective study, 174 patients with acute ischemic stroke who had been prescribed aspirin for at least one month due to the risk of vascular disease, along with 106 healthy volunteers, were included as part of the study group. The results of our study indicate that AR was detected in 21.3% of the patient group. According to the results of an analysis of the polymorphism of the ABCB1 C3435T in patients with AR compared to those with aspirin sensitivity, patients with AR possessed more heterozygous (CT) and homozygous genotypes (TT) than those with aspirin sensitivity (p = 0.001). Based on multivariate logistic regression analysis of factors affecting AR in acute ischemic stroke patients, hypertension (OR: 5.679; 95% CI: 1.144–28.19; p = 0.034), heterozygous (CT) genotype (OR: 2.557; 95% CI: 1.126–5.807; p = 0.025), increased platelet values (OR: 1.005; 95% CI: 1.001–1.009; p = 0.029), and CRP/albumin values (OR: 1.547; 95% CI: 1.005–2.382; p = 0.047) were found to be associated with a greater risk of AR. The presence of heterozygous (CT) genotype in the ABCB1 C3435T gene region in the Turkish population is associated with an increased risk of AR. When planning aspirin therapy, it is crucial to consider the ABCB1 (MDR-1) C3435T polymorphism.

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Data Availability

The datasets generated during the current study are available from the corresponding author on reasonable request.

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Funding

This study was financially supported by University of Health Sciences, Scientific Researches Project Department with the approval number of 2021/135.

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Authors and Affiliations

  1. Department of Emergency Medicine, University of Health Sciences, Kanuni Training and Research Hospital, Istanbul, Turkey

    Emrah Yurek

  2. Department of Emergency Medicine, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey

    Burcu Genc Yavuz & Sahin Colak

  3. Department of Molecular Biology and Genetics, Institute of Health Sciences, University of Health Sciences, Istanbul, Turkey

    Esra Guzel Tanoglu

  4. Department of Neurology, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Turkey

    Erdem Gurkas

  5. Department of Emergency Medicine, University of Health Sciences, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey

    Ibrahim Altundag

  6. TUBITAK National Metrology Institute, Kocaeli, Turkey

    Burhanettin Yalcinkaya

  7. Department of Emergency Medicine, University of Health Sciences, Kartal Dr. Lütfi Kırdar City Hospital, Istanbul, Turkey

    Erdal Yılmaz

Authors
  1. Emrah Yurek
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  2. Burcu Genc Yavuz
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  3. Esra Guzel Tanoglu
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  4. Erdem Gurkas
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  6. Burhanettin Yalcinkaya
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  7. Erdal Yılmaz
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  8. Sahin Colak
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Contributions

EY, BGY, EGT and SC designed this study. EY, BGY, EG, İA, EY and SC supervised the overall data collection process, had full access to all the data in the study, and takes responsibility for the integrity of the data. EY, EGT, BY and EY conducted the data analysis. EY, BGY, İA and EGT wrote the initial draft of the article. All authors provided substantial review and feedback on the final version of the article. BGY takes responsibility for the paper as a whole. All authors have read and approved the submitted manuscript. This manuscript has not been submitted nor published elsewhere in whole or in part.

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Correspondence to Burcu Genc Yavuz.

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Yurek, E., Yavuz, B.G., Tanoglu, E.G. et al. The Effect of the ABCB1(MDR-1) C3435T Polymorphism in Turkish Patients with Aspirin Resistance in Acute Ischemic Stroke. Transl. Stroke Res. (2023). https://doi.org/10.1007/s12975-023-01175-z

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  • DOI: https://doi.org/10.1007/s12975-023-01175-z

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