Abstract
This study aimed to develop a photostable ointment containing 0.13% of silver chloride and evaluate the antimicrobial activity of the product. The ointment formulation was prepared by the reaction between silver nitrate and sodium chloride in a mixture of polyethylene glycol 600 and polyethylene glycol 4000 in a ratio of 5:2 (w/w). When in contact with water, silver chloride nanocubes precipitated out of the formulation. These particles had an average diameter of about 180 nm and a zeta potential of about − 41 mV. Their optical properties and crystalline nature were confirmed by UV–Vis spectroscopy and XRD analysis, respectively. The product could maintain the liberation of silver within 3 days and up to 7 days with 0.267 mg silver released in total. Moreover, the product had shown broad-spectrum antibiotic activities against both Gram-positive and Gram-negative strains. The antibacterial effects of 0.13% silver chloride ointment were better than those of the 1% silver sulfadiazine cream at all tested organisms. These superior results suggest that this ointment formulation may be an effective therapeutic agent for preventing wound infection.
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T. H. Nguyen and T. T. B. Nguyen conceived of the presented idea; T. T. B. Nguyen and X. T. Nguyen planned and carried out the experiments; X. T. Nguyen wrote the manuscript in consultation with T. T. B. Nguyen; T. H. Nguyen supervised the project.
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Nguyen, T.T.B., Nguyen, T.H. & Nguyen, X.T. Preparation and Antibacterial Evaluation of Polyethylene Glycol Ointment Containing In Situ Silver Chloride Nanoparticles. BioNanoSci. 12, 203–209 (2022). https://doi.org/10.1007/s12668-021-00935-1
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DOI: https://doi.org/10.1007/s12668-021-00935-1