Skip to main content

Advertisement

SpringerLink
Log in

Tracking the Virulent Helicobacter pylori Strains Instead of Its Pan-Screening to Prevent Gastric Cancer

  • Published:
BioNanoScience Aims and scope Submit manuscript

Abstract

Gastric colonization by Helicobacter pylori is associated with the development of chronic gastroduodenal disorders, including atrophic gastritis, duodenal ulcer, and gastric cancer. Mainly over the last three decades, exemplary research efforts and clinical trials have been aimed at achieving the best formulation and treatment regimens for mass eradication of H. pylori. Reflecting on these efforts, we would like to pose the following questions: Is it mandatory to aim for eradication of all H. pylori strains or only specific strains thereof? What populations should be selected for antibiotic therapy? Until now, the screen-and-treat strategy has been the best recommendation by the guidelines for clinicians caring for patients from high-risk populations, but targeting the virulent strains of H. pylori had not been considered. However, updated guidelines based on renewed concepts to improve H. pylori treatment could help clinicians better manage their patients who suffer from gastric cancer. Importantly, preventing gastric cancer will not be feasible by the screen-and-test strategy alone. Here, we present a commentary proposing a renewed consideration of H. pylori screening and treatment and their potential impact on H. pylori eradication in anticipation of preventing gastric cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Watanabe, T., Tada, M., Nagai, H., Sasaki, S., & Nakao, M. (1998). Helicobacter pylori infection induces gastric cancer in mongolian gerbils. Gastroenterology, 115(3), 642–648. https://doi.org/10.1016/s0016-5085(98)70143-x.

    Article  Google Scholar 

  2. Noto, J. M., Romero-Gallo, J., Piazuelo, M. B., & Peek, R. M. (2016). The Mongolian Gerbil: a robust model of Helicobacter pylori-induced gastric inflammation and cancer. In Gastrointestinal Physiology and Diseases (pp. 263–280). Springer.

  3. Shimizu, N., Ikehara, Y., Inada, K., Nakanishi, H., Tsukamoto, T., Nozaki, K., Kaminishi, M., Kuramoto, S., Sugiyama, A., Katsuyama, T., & Tatematsu, M. (2000). Eradication diminishes enhancing effects of Helicobacter pylori infection on glandular stomach carcinogenesis in Mongolian gerbils. Cancer Research, 60(6), 1512–1514.

    Google Scholar 

  4. Venerito, M., Link, A., Rokkas, T., & Malfertheiner, P. (2019). Review: Gastric cancer—clinical aspects. Helicobacter, 24(Suppl 1), e12643. https://doi.org/10.1111/hel.12643.

    Article  Google Scholar 

  5. Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018). Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a Cancer Journal for Clinicians, 68(6), 394–424. https://doi.org/10.3322/caac.21492.

    Article  Google Scholar 

  6. Fitzmaurice, C., Allen, C., Barber, R. M., Barregard, L., Bhutta, Z. A., Brenner, H., Dicker, D. J., Chimed-Orchir, O., Dandona, R., Dandona, L., Fleming, T., Forouzanfar, M. H., Hancock, J., Hay, R. J., Hunter-Merrill, R., Huynh, C., Hosgood, H. D., Johnson, C. O., Jonas, J. B., Khubchandani, J., Kumar, G. A., Kutz, M., Lan, Q., Larson, H. J., Liang, X., Lim, S. S., Lopez, A. D., MacIntyre, M. F., Marczak, L., Marquez, N., Mokdad, A. H., Pinho, C., Pourmalek, F., Salomon, J. A., Sanabria, J. R., Sandar, L., Sartorius, B., Schwartz, S. M., Shackelford, K. A., Shibuya, K., Stanaway, J., Steiner, C., Sun, J., Takahashi, K., Vollset, S. E., Vos, T., Wagner, J. A., Wang, H., Westerman, R., Zeeb, H., Zoeckler, L., Abd-Allah, F., Ahmed, M. B., Alabed, S., Alam, N. K., Aldhahri, S. F., Alem, G., Alemayohu, M. A., Ali, R., Al-Raddadi, R., Amare, A., Amoako, Y., Artaman, A., Asayesh, H., Atnafu, N., Awasthi, A., Saleem, H. B., Barac, A., Bedi, N., Bensenor, I., Berhane, A., Bernabe, E., Betsu, B., Binagwaho, A., Boneya, D., Campos-Nonato, I., Castaneda-Orjuela, C., Catala-Lopez, F., Chiang, P., Chibueze, C., Chitheer, A., Choi, J. Y., Cowie, B., Damtew, S., das Neves, J., Dey, S., Dharmaratne, S., Dhillon, P., Ding, E., Driscoll, T., Ekwueme, D., Endries, A. Y., Farvid, M., Farzadfar, F., Fernandes, J., Fischer, F., GH, T. T., Gebru, A., Gopalani, S., Hailu, A., Horino, M., Horita, N., Husseini, A., Huybrechts, I., Inoue, M., Islami, F., Jakovljevic, M., James, S., Javanbakht, M., Jee, S. H., Kasaeian, A., Kedir, M. S., Khader, Y. S., Khang, Y. H., Kim, D., Leigh, J., Linn, S., Lunevicius, R., HMA, E. R., Malekzadeh, R., Malta, D. C., Marcenes, W., Markos, D., Melaku, Y. A., Meles, K. G., Mendoza, W., Mengiste, D. T., Meretoja, T. J., Miller, T. R., Mohammad, K. A., Mohammadi, A., Mohammed, S., Moradi-Lakeh, M., Nagel, G., Nand, D., Le Nguyen, Q., Nolte, S., Ogbo, F. A., Oladimeji, K. E., Oren, E., Pa, M., Park, E. K., Pereira, D. M., Plass, D., Qorbani, M., Radfar, A., Rafay, A., Rahman, M., Rana, S. M., Soreide, K., Satpathy, M., Sawhney, M., Sepanlou, S. G., Shaikh, M. A., She, J., Shiue, I., Shore, H. R., Shrime, M. G., So, S., Soneji, S., Stathopoulou, V., Stroumpoulis, K., Sufiyan, M. B., Sykes, B. L., Tabares-Seisdedos, R., Tadese, F., Tedla, B. A., Tessema, G. A., Thakur, J. S., Tran, B. X., Ukwaja, K. N., BSC, U., Vlassov, V. V., Weiderpass, E., Wubshet Terefe, M., Yebyo, H. G., Yimam, H. H., Yonemoto, N., Younis, M. Z., Yu, C., Zaidi, Z., MES, Z., Zenebe, Z. M., CJL, M., & Naghavi, M. (2017). Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: a systematic analysis for the global burden of disease study. JAMA Oncology, 3(4), 524–548. https://doi.org/10.1001/jamaoncol.2016.5688.

    Article  Google Scholar 

  7. Eghdami, A., Ostovar, R., Jafari, A., Palmer, A. J., Bordbar, N., & Ravangard, R. (2019). Economic burden of gastric cancer: a case study of Iran. Cancer Control, 26(1), 1073274819837185. https://doi.org/10.1177/1073274819837185.

    Article  Google Scholar 

  8. den Hoed, C. M., & Kuipers, E. J. (2016). Gastric cancer: how can we reduce the incidence of this disease? Current Gastroenterology Reports, 18(7), 34. https://doi.org/10.1007/s11894-016-0506-0.

    Article  Google Scholar 

  9. Chey, W. D., Wong, B. C., & Practice Parameters Committee of the American College of Gastroenterology. (2007). American College of Gastroenterology guideline on the management of Helicobacter pylori infection. The American Journal of Gastroenterology, 102(8), 1808–1825. https://doi.org/10.1111/j.1572-0241.2007.01393.x.

    Article  Google Scholar 

  10. Fock, K. M., Katelaris, P., Sugano, K., Ang, T. L., Hunt, R., Talley, N. J., Lam, S. K., Xiao, S. D., Tan, H. J., Wu, C. Y., Jung, H. C., Hoang, B. H., Kachintorn, U., Goh, K. L., Chiba, T., Rani, A. A., & Second Asia-Pacific, C. (2009). Second Asia–Pacific Consensus Guidelines for Helicobacter pylori infection. Journal of Gastroenterology and Hepatology, 24(10), 1587–1600. https://doi.org/10.1111/j.1440-1746.2009.05982.x.

    Article  Google Scholar 

  11. Chey, W. D., Leontiadis, G. I., Howden, C. W., & Moss, S. F. (2017). ACG clinical guideline: treatment of Helicobacter pylori infection. The American Journal of Gastroenterology, 112(2), 212–239. https://doi.org/10.1038/ajg.2016.563.

    Article  Google Scholar 

  12. Kim, Y. I., Cho, S. J., Lee, J. Y., Kim, C. G., Kook, M. C., Ryu, K. W., Kim, Y. W., & Choi, I. J. (2016). Effect of Helicobacter pylori eradication on long-term survival after distal gastrectomy for gastric cancer. Cancer Research and Treatment, 48(3), 1020–1029. https://doi.org/10.4143/crt.2015.264.

    Article  Google Scholar 

  13. Wu, J. Y., Lee, Y. C., & Graham, D. Y. (2019). The eradication of Helicobacter pylori to prevent gastric cancer: a critical appraisal. Expert Review of Gastroenterology & Hepatology, 13(1), 17–24. https://doi.org/10.1080/17474124.2019.1542299.

    Article  Google Scholar 

  14. Zeng, M., Mao, X. H., Li, J. X., Tong, W. D., Wang, B., Zhang, Y. J., Guo, G., Zhao, Z. J., Li, L., Wu, D. L., Lu, D. S., Tan, Z. M., Liang, H. Y., Wu, C., Li, D. H., Luo, P., Zeng, H., Zhang, W. J., Zhang, J. Y., Guo, B. T., Zhu, F. C., & Zou, Q. M. (2015). Efficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet, 386(10002), 1457–1464. https://doi.org/10.1016/S0140-6736(15)60310-5.

    Article  Google Scholar 

  15. Liu, W., Zeng, Z., Luo, S., Hu, C., Xu, N., Huang, A., Zheng, L., Sundberg, E. J., Xi, T., & Xing, Y. (2019). Gastric subserous vaccination with Helicobacter pylori vaccine: an attempt to establish tissue-resident CD4+ memory T cells and induce prolonged protection. Frontiers in Immunology, 10, 1115. https://doi.org/10.3389/fimmu.2019.01115.

    Article  Google Scholar 

  16. Fischbach, W., & Malfertheiner, P. (2018). Helicobacter Pylori infection: when to eradicate, how to diagnose and treat. Deutsches Ärzteblatt International, 115(25), 429.

    Google Scholar 

  17. Malfertheiner, P., Megraud, F., O'Morain, C. A., Atherton, J., Axon, A. T., Bazzoli, F., Gensini, G. F., Gisbert, J. P., Graham, D. Y., Rokkas, T., El-Omar, E. M., Kuipers, E. J., & European Helicobacter Study G. (2012). Management of Helicobacter pylori infection—The Maastricht IV/ Florence consensus report. Gut, 61(5), 646–664. https://doi.org/10.1136/gutjnl-2012-302084.

    Article  Google Scholar 

  18. Malfertheiner, P., Megraud, F., O’Morain, C. A., Gisbert, J. P., Kuipers, E. J., Axon, A. T., Bazzoli, F., Gasbarrini, A., Atherton, J., Graham, D. Y., Hunt, R., Moayyedi, P., Rokkas, T., Rugge, M., Selgrad, M., Suerbaum, S., Sugano, K., El-Omar, E. M., & European H, Microbiota Study G, Consensus p. (2017). Management of Helicobacter pylori infection—the Maastricht V/Florence Consensus Report. Gut, 66(1), 6–30. https://doi.org/10.1136/gutjnl-2016-312288.

    Article  Google Scholar 

  19. Thung, I., Aramin, H., Vavinskaya, V., Gupta, S., Park, J. Y., Crowe, S. E., & Valasek, M. A. (2016). Review article: the global emergence of Helicobacter pylori antibiotic resistance. Alimentary Pharmacology & Therapeutics, 43(4), 514–533. https://doi.org/10.1111/apt.13497.

    Article  Google Scholar 

  20. Graham, D. Y., & Yamaoka, Y. (2000). Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter, 5 Suppl 1(S1), S3–S9 discussion S27-31.

    Article  Google Scholar 

  21. Lu, H., Yamaoka, Y., & Graham, D. Y. (2005). Helicobacter pylori virulence factors: facts and fantasies. Current Opinion in Gastroenterology, 21(6), 653–659.

    Article  Google Scholar 

  22. Yamaoka, Y. (2010). Mechanisms of disease: Helicobacter pylori virulence factors. Nature Reviews. Gastroenterology & Hepatology, 7(11), 629–641. https://doi.org/10.1038/nrgastro.2010.154.

    Article  Google Scholar 

  23. Arachchi, H. S., Kalra, V., Lal, B., Bhatia, V., Baba, C. S., Chakravarthy, S., Rohatgi, S., Sarma, P. M., Mishra, V., Das, B., & Ahuja, V. (2007). Prevalence of duodenal ulcer-promoting gene (dupA) of Helicobacter pylori in patients with duodenal ulcer in North Indian population. Helicobacter, 12(6), 591–597. https://doi.org/10.1111/j.1523-5378.2007.00557.x.

    Article  Google Scholar 

  24. Salimzadeh, L., Bagheri, N., Zamanzad, B., Azadegan-Dehkordi, F., Rahimian, G., Hashemzadeh-Chaleshtori, M., Rafieian-Kopaei, M., Sanei, M. H., & Shirzad, H. (2015). Frequency of virulence factors in Helicobacter pylori-infected patients with gastritis. Microbial Pathogenesis, 80, 67–72. https://doi.org/10.1016/j.micpath.2015.01.008.

    Article  Google Scholar 

  25. Dore, M. P., Lu, H., & Graham, D. Y. (2016). Role of bismuth in improving Helicobacter pylori eradication with triple therapy. Gut, 65(5), 870–878. https://doi.org/10.1136/gutjnl-2015-311019.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research School of Biology, The Australian National University, Canberra, ACT, 2600, Australia

    Farid Rahimi

  2. Department of Bacteriology, Faculty of Medical Sciences, Tarbiat Modares University, P.O. Box 14115-111, Tehran, Iran

    Amin Talebi Bezmin Abadi

Authors
  1. Farid Rahimi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amin Talebi Bezmin Abadi
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Amin Talebi Bezmin Abadi.

Ethics declarations

Conflict of Interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rahimi, F., Talebi Bezmin Abadi, A. Tracking the Virulent Helicobacter pylori Strains Instead of Its Pan-Screening to Prevent Gastric Cancer. BioNanoSci. 10, 315–317 (2020). https://doi.org/10.1007/s12668-019-00678-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12668-019-00678-0

Keywords

Search

Navigation