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Polyelectrolyte Microcapsule Arrays: Preparation and Biomedical Applications

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Abstract

In the need of development of versatile and flexible platforms for sensing and other biomedical applications, micro- and nanostructured particle arrays attract strong scientific interest. In this review we focus on fabrication of arrays of polyelectrolyte layer-by-layer assembled microcapsules and bio-related applications of such arrays. A cargo encapsulated in the microcapsules can be released on demand, thus opening perspectives for biosensing, diagnostics, controlled drug delivery, and tissue engineering. Here, we also consider a new composite system—microcapsules embedded into polymeric film—both components are made by the LbL technique. Fabrication approaches and perspectives in the preparation and in the use of the microcapsule arrays are addressed.

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Acknowledgments

The reported study was partially supported by RFBR (research project number 12-03-33088) and by the individual grant of Foundation for Assistance to Small Innovative Enterprises in Scientific and Technological Sphere under the program “U.M.N.I.K.” (project number 17259). D.V. Volodkin thanks to Alexander von Humboldt Foundation for support (Sofja Kovalevskaja Program).

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Authors and Affiliations

  1. Saratov State University, Astrakhanskaya St., 83, 410012, Saratov, Russia

    Alena S. Sergeeva & Dmitry A. Gorin

  2. Pugacheva St., 44/52, app. 18, 410056, Saratov, Russia

    Alena S. Sergeeva

  3. Bolshaya Sadovaya St., 192/208, app. 277, 410012, Saratov, Russia

    Dmitry A. Gorin

  4. Fraunhofer Institute for Biomedical Engineering, Muehlenberg St. 13 IBMT, 14476, Potsdam, Germany

    Dmitry V. Volodkin

  5. Seydlitzstrasse 18C, 10557, Berlin, Germany

    Dmitry V. Volodkin

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  1. Alena S. Sergeeva
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  2. Dmitry A. Gorin
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  3. Dmitry V. Volodkin
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Correspondence to Alena S. Sergeeva.

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Sergeeva, A.S., Gorin, D.A. & Volodkin, D.V. Polyelectrolyte Microcapsule Arrays: Preparation and Biomedical Applications. BioNanoSci. 4, 1–14 (2014). https://doi.org/10.1007/s12668-013-0121-6

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