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Is mean platelet volume a simple marker of non-alcoholic fatty liver disease?

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Abstract

Background

Due to the increasing prevalence of non-alcoholic fatty liver disease (NAFLD), there was a need to establish non-invasive tests for its detection. Mean platelet volume (MPV) is an inexpensive, practical and easily accessible marker of inflammation in many disorders. Our study was aimed at investigating the relationship between MPV and both NAFLD and liver histology.

Methods

Total 290 patients with biopsy-proven NAFLD (n = 124) and 108 control patients were included in the study. To exclude the effect of other diseases on MPV, we included 156 patient controls in our study. Those whohave liver-related diseases and those who use drugs that may cause fatty liver were not included in the study. Liver biopsy was performed for those whose alanine aminotransferase level persisted for >6 months above the upper limits.

Results/Conclusion

We found that MPV was significantly higher in the NAFLD group compared with the control group, and MPV had an independent predictive value for the development of NAFLD. We determined that the number of platelets was significantly lower in the NAFLD group compared with that in the control group. We compared MPV values histologically with both stage and grade in all patients with biopsy-proven NAFLD and found that MPV had a significant positive correlation with stage. We observed a positive correlation between MPV and non-alcoholic steatohepatitis grade, but this was not statistically significant. MPV can be useful because it is simple, easy to measure, cost-effective, and routinely tested in daily practice. MPV can be used as a simple marker of NAFLD and an indicator of fibrosis-stage in NAFLD.

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Authors and Affiliations

  1. Gastroenterology Department, Cukurova University, 01060, Adana, Turkey

    Ümit Karaoğullarindan, Oguz Üsküdar, Emre Odabaş, Melike Saday, Anil Delik, Yüksel Gümürdülü & Sedef Kuran

  2. Endocrinology Department, Cukurova University, Adana, Turkey

    Gamze Akkuş

Authors
  1. Ümit Karaoğullarindan
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  2. Oguz Üsküdar
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  5. Gamze Akkuş
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Contributions

UK, YG, OU, SK conceptualized the study. UK, GA and OU designed it. The material/data collection was done by UK, MS and AD. UK, AD and SK did the analysis. The literature review was done by UK, OU,YG and SK, UK, GA and SK wrote the draft. UK,OU, GA, YG, SK performed the critical review. 

Corresponding author

Correspondence to Ümit Karaoğullarindan.

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Conflict of interest

UK, OU, EO, MS, GA, AD, YG and SK  declare no competing interests.

Ethics statement

The study was performed conforming to the Helsinki Declaration of 1975, as revised in 2000 and 2008 concerning human and animal rights, and the authors followed the policy concerning informed consent as shown on Springer.com.

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The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology or the printer/publishers are responsible for the results/findings and content of this article.

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Karaoğullarindan, Ü., Üsküdar, O., Odabaş, E. et al. Is mean platelet volume a simple marker of non-alcoholic fatty liver disease?. Indian J Gastroenterol 42, 219–225 (2023). https://doi.org/10.1007/s12664-022-01330-8

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  • DOI: https://doi.org/10.1007/s12664-022-01330-8

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