Abstract
Background
Deceased donor liver transplant (DDLT) is an uncommon procedure in India. We present our experience of DDLT from a public sector teaching hospital.
Methods
A retrospective analysis of all DDLT was performed from April 2012 till September 2016. Demographics, intraoperative, donor factors, morbidity, and outcome were analyzed.
Results
During the study period, 305 liver transplants were performed, of which 36 were DDLT (adult 32, pediatric 4; 35 grafts; 1 split). The median age was 42.5 (1–62) years; 78% were men. The median donor age was 28 (1–77) years; 72.2% were men. About 45% of organs were procured from outside of Delhi and 67% of all grafts used were marginal. Three of 38 liver grafts (7.8%) were rejected due to gross steatosis. Commonest indication was cryptogenic cirrhosis (19.4%). The median model for end-stage liver disease sodium and pediatric end-stage liver disease scores were 23.5 (9–40) and 14.5 (9–22), respectively. Median warm and cold ischemia times were 40 (23–56) and 396 (111–750) min, respectively. Major morbidity of grade III and above occurred in 63.8%. In hospital (90 days), mortality was 16.7% and there were two late deaths because of chronic rejection and biliary sepsis. The overall survival was 77.8% at median follow up of 8.6 (1–54) months.
Conclusions
DDLT can be performed with increasing frequency and safety in a public sector hospital. The perioperative and long-term outcomes are acceptable despite the fact that most organs were extended criteria grafts.
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VP, DPB, SK, KGSB, PKS, SVS, VS, CKP, and SKS declare that they have no conflicts of interest.
Ethics statement
The study was approved by the institute’s ethics review board and is in compliance with the Helsinki Declaration, 1964, and its subsequent modifications. Standard medical care was provided to all participants. Written informed consent in a standard format was obtained from all patients who underwent surgery. Since this was a retrospective study, participation in this study did not change the consent process or decision for surgery. Formal consent for participation in this study is therefore not required.
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Pamecha, V., Borle, D.P., Kumar, S. et al. Deceased donor liver transplant: Experience from a public sector hospital in India. Indian J Gastroenterol 37, 18–24 (2018). https://doi.org/10.1007/s12664-017-0801-1
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DOI: https://doi.org/10.1007/s12664-017-0801-1