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Intravascular Papillary Endothelial Hyperplasia of the Mandible in a 66 Year-Old Woman

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Abstract

Intravascular papillary endothelial hyperplasia (IPEH) is a rare benign vascular non-neoplastic lesion that is characterized by papillary proliferation of vascular endothelial cells. Masson first described this lesion in 1923, and since then, it has been named Masson’s tumor, intravascular angiomatosis, Masson’s lesion, Masson’s pseudoangiosarcoma, Masson’s hemangioma, and vegetant intravascular hemangioendothelioma. The term IPEH is currently the most illustrative and the most frequently used in the literature. This lesion seems to occur in any blood vessel in the body, but it is more likely to be observed in the skin and subcutaneous tissues of the head and neck region, fingers, and trunk. Mandibular involvement is rare. IPEH’s etiology remains unknown. Histopathological examination reveals a reactive proliferation of endothelial cells organized in minor papillary assemblies with hypocellular and hyalinized centers and arising from an organized thrombus. The appropriate treatment for IPEH is the excision with healthy margins; prognosis is good, with rare recurrences that may occur when the lesion is incompletely excised. The aim of the present article is to report and discuss the clinical, histopathological, immunohistochemical, and therapeutic issues of a case of IPEH of the mandible in a 66-year-old woman.

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Authors and Affiliations

  1. Department of Dentistry, AOU Maggiore Della Carità, Novara, Italy

    Paolo Boffano & Mario Migliario

  2. Department of Health Sciences, University of Eastern Piedmont, Novara, Italy

    Paolo Boffano & Matteo Brucoli

  3. Department of Maxillofacial Surgery, AOU Maggiore Della Carità, Novara, Italy

    Matteo Brucoli

  4. Department of Health Sciences, University of Catanzaro “Magna Graecia”, Catanzaro, Italy

    Martina Ferrillo & Amerigo Giudice

  5. Department of Translational Medicine, University of Eastern Piedmont, Novara, Italy

    Mario Migliario

Authors
  1. Paolo Boffano
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  2. Matteo Brucoli
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  3. Martina Ferrillo
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  4. Amerigo Giudice
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  5. Mario Migliario
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Contributions

MM contributed to conceptualization; MM and PB provided methodology; AG and MM performed validation; PB and MF carried out formal analysis; PB and MB performed data curation; PB performed writing—original draft preparation; PB, MF, and MM performed writing—review and editing; MB and MM performed supervision. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Paolo Boffano.

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Boffano, P., Brucoli, M., Ferrillo, M. et al. Intravascular Papillary Endothelial Hyperplasia of the Mandible in a 66 Year-Old Woman. J. Maxillofac. Oral Surg. (2024). https://doi.org/10.1007/s12663-023-02102-3

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  • DOI: https://doi.org/10.1007/s12663-023-02102-3

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