Abstract
Patients with hypoplasia of the midface normally present a flattening of their facial profile due to insufficient development of the nose and maxilla. Treatment aimed to restore function and an aesthetic appearance calls for a Le Fort III osteotomy and the advancement of the midfacial segment either through distraction or interposition of autogenous bone blocks. However, drawbacks in using autogenous bone suggest that use of alternative graft material may be advisable. The present report describes a Le Fort III advancement using two enzyme-treated equine cancellous bone blocks to correct syndromic midfacial hypoplasia in a 22-year-old patient. A 12-mm surgical advancement was achieved, improving the patient’s facial profile. At the 28-month follow-up, the midface advanced position was stable. Equine bone blocks could be a valid alternative to autogenous bone in Le Fort III midface advancement.
References
McWilliam J (1976) Hypoplasia of the middle third of the face—a morphological study. Angle Orthod 46:260–267
Hopkin GB (1963) Hypoplasia of the middle third of the face associated with congenital absence of the anterior nasal spine, depression of the nasal bones, and angle class III malocclusion. Br J Plast Surg 16:146–153
Saltaji H, Altalibi M, Major MP et al (2014) Le Fort III distraction osteogenesis versus conventional Le Fort III osteotomy in correction of syndromic midfacial hypoplasia: a systematic review. J Oral Maxillofac Surg 72:959–972
Tiwana PS, Turvey TA (2004) Subcranial procedures in craniofacial surgery: the Le Fort III osteotomy. Oral Maxillofac Surg Clin N Am 16:493–501
Bradley JP, Gabbay JS, Taub PJ et al (2006) Monobloc advancement by distraction osteogenesis decreases morbidity and relapse. Plast Reconstr Surg 118:1585–1597
Di Stefano DA, Artese L, Iezzi G et al (2009) Alveolar ridge regeneration with equine spongy bone: a clinical, histological, and immunohistochemical case series. Clin Implant Dent Relat Res 11:90–100
Artese L, Piattelli A, Di Stefano DA et al (2011) Sinus lift with autologous bone alone or in addition to equine bone: an immunohistochemical study in man. Implant Dent 20:383–388
Pistilli R, Signorini L, Pisacane A et al (2013) Case of severe bone atrophy of the posterior maxilla rehabilitated with blocks of equine origin bone: histological results. Implant Dent 22:8–15
Santini S, Barbera P, Modena M et al (2011) Equine-derived bone substitutes in orthopedics and traumatology: authors’ experience. Minerva Chir 66:63–72
Perrotti V, Nicholls BM, Piattelli A (2009) Human osteoclast formation and activity on an equine spongy bone substitute. Clin Oral Implants Res 20:17–23
Baumhauer J, Pinzur MS, Donahue R et al (2014) Site selection and pain outcome after autologous bone graft harvest. Foot Ankle Int 35:104–107
Grover V, Kapoor A, Malhotra R, Sachdeva S (2011) Bone allografts: a review of safety and efficacy. Indian J Dent Res 22:496
Zhang J, Liu W, Schnitzler V et al (2014) Calcium phosphate cements for bone substitution: chemistry, handling and mechanical properties. Acta Biomater 10:1035–1049
Kolk A, Handschel J, Drescher W et al (2012) Current trends and future perspectives of bone substitute materials—from space holders to innovative biomaterials. J Cranio Maxillofac Surg 40:706–718
Ortiz-Monasterio F, Fuente del Campo A, Carillo A (1978) Advancement of the orbits and the midface in one piece, combined with frontal repositioning for the correction of Crouzon’s deformities. Plast Reconstr Surg 61:507–516
Satoh K, Mitsukawa N, Hosaka Y (2003) Dual midfacial distraction osteogenesis: Le Fort III minus I and Le Fort I for syndromic craniosynostosis. Plast Reconstr Surg 111:1019–1028
Sakamoto Y, Nakajima H, Tamada I et al (2014) Le Fort IV + I distraction osteogenesis using an internal device for syndromic craniosynostosis. J Oral Maxillofac Surg 72:788–795
Steinhäuser EW (1980) Variations of Le Fort II osteotomies for correction of midfacial deformities. J Maxillofac Surg 8:258–265
Paliga JT, Goldstein JA, Storm PB et al (2013) Monobloc minus Le Fort II for single-stage treatment of the Apert phenotype. J Craniofac Surg 24:596–598
Buchanan EP, Hyman CH (2013) Le Fort I osteotomy. Semin Plast Surg 27:149–154
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Mattioli B, Iacoviello P, Aldiano C and Verrina G declare that they have no conflict of interest.
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Mattioli, B., Iacoviello, P., Aldiano, C. et al. Subcranial Le Fort III Advancement with Equine-Derived Bone Grafts to Correct Syndromic Midfacial Hypoplasia: A Case Report. J. Maxillofac. Oral Surg. 17, 296–300 (2018). https://doi.org/10.1007/s12663-017-1058-z
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DOI: https://doi.org/10.1007/s12663-017-1058-z