Abstract
Purpose
To propose that low dose aspirin therapy need not be withdrawn for routine dental extraction procedure.
Aim
This study was designed to evaluate the post operative bleeding in patients on low dose aspirin therapy by dividing them into two groups: one with withdrawing and the other without withdrawing the regime before dental extraction.
Materials and Methods
This study included 80 patients on low dose aspirin therapy. They were divided into two groups of 40 patients each; Group I (control group) included patients on who were asked to stop the medication 5 days prior to dental extraction; Group II (test group) included patients who were asked not to stop the medication prior to dental extraction. Strict atraumatic extractions were performed by a single surgeon. Data were analyzed using the independent “t” test @ 80 % power.
Results
The mean pre-operative bleeding time in the control group was 87.75 s and the test group was 95.75 s which was statistically significant (p < 0.05). The mean pre-operative clotting time in the control group was 228.63 s and the test group was 246.25 s which was also statistically significant (p < 0.05). No patients in either group had any episode of prolonged postoperative bleeding following extraction from the surgical site and no local haemostatic measures had to be used except for one patient in Group II.
Conclusion
Authors conclude from this study that dental extraction procedures in patients on low-dose therapy can be safely carried out without stopping the antiplatelet therapy.
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References
Ardekian L, Gaspar R, Peled M et al (2000) Does low-dose aspirin therapy complicate oral surgical procedures? JADA 131:331–335
Brennan MT, Valerin MA, Noll LJ, Napeñas JJ, Kent ML et al (2008) Aspirin use and post-operative bleeding from dental extractions. J Dent Res 87(8):740–744
Cardona-Tortajada F, Sainz-Gómez E et al (2009) Dental extractions in patients on antiplatelet therapy: a study conducted by the Oral Health Department of the Navarre Health Service (Spain). Med Oral Patol Oral Cir Bucal 14(11):e588–e592
Krishnan B, Shenoy N, Alexander M (2008) Exodontia and antiplatelet therapy. J Oral Maxillofac Surg 66:2063–2066
Little JW, Miller CS, Henry RG et al (2002) Antithrombotic agents: implications in dentistry. OOOE 93:544–551
Lockhart PB, Gibson J, Pond SH, Leitch J (2003) Dental management considerations for the patient with an acquired coagulopathy. Part 2: Coagulopathies from drugs. Br Dent J 195(9):405–501
Madan GA, Madan SG, Madan G, Madan AD (2005) Minor oral surgery without stopping daily low-dose aspirin therapy: a study of 51 patients. J Oral Maxillofac Surg 63:1262–1265
Sonksen JR, Kong KL, Holder R (1999) Magnitude and time course of impaired primary haemostasis after stopping chronic low and medium dose aspirin in healthy volunteers. Br J Anaesth 82:360–365
Valerin MA, Brennan MT, Napenas JJ et al (2006) Relationship between aspirin use and post operative bleeding from dental extractions in a healthy population. OOOE 102:326
Anti-platelet Trialists Collaboration (1994) Collaborative overview of randomized trials of antiplatelet therapy: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Br Med J Clin Res 308:81
Terezhalmy GT, Lichitin AE (1996) Antithrombotic, anticoagulant and thrombolytic agents. Dent Clin N Am 40:649
De Caterina R, Lanza M, Manca G et al (1994) Bleeding time and bleeding: an analysis of the relationship of the bleeding time test with parameters of surgical bleeding. Blood 84:3363
Kitchen L et al (1982) Effect of drug-induced platelet dysfunction on surgical bleeding. Am J Surg 143:215
Ferraris VA, Swanson E (1983) Aspirin usage and perioperative blood loss in patients undergoing unexpected operations. Surg Gynecol Obstet 156(4):439–442
Ferraris VA, Ferraris SP, Lough FC, Berry WR (1988) Preoperative aspirin ingestion increases operative blood loss after coronary artery bypass grafting. Ann Thorac Surg 45(1):71–74
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Eapen, B.V., Baig, M.F. & Avinash, S. An Assessment of the Incidence of Prolonged Postoperative Bleeding After Dental Extraction Among Patients on Uninterrupted Low Dose Aspirin Therapy and to Evaluate the Need to Stop Such Medication Prior to Dental Extractions. J. Maxillofac. Oral Surg. 16, 48–52 (2017). https://doi.org/10.1007/s12663-016-0912-8
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DOI: https://doi.org/10.1007/s12663-016-0912-8