Abstract
Introduction
Third molar surgery (TMS) became a routine, safe office procedure with generally predictable outcomes and relative low cost. It affects quality of life (QOL) of patients by causing considerable pain, swelling and trismus; by changing what people eat, their speech in the first few days after surgery. The purpose of the present study was to improve QOL of patient after lower TMS by injecting single dose 8 mg submucosal dexamethasone.
Materials and Methods
Forty healthy adult subjects of either gender underwent surgical removal of the lower impacted third molar under local anaesthesia and after being randomly assigned to receive either 8 mg dexamethasone submucosal injection or normal saline injection in proximity to surgical site.
Statistical Analysis Used
Chi-square test, Mann–Whitney U test (Z), t student and unpaired t test, and Fisher extract test were used for calculation of data.
Results
Facial swelling, trismus showed significant reduction immediate postoperative day in dexamethasone groups. Patient perception postoperative pain on VAS score was not significant. PoSSe statistics, only three out of seven subscales showed a statistically significant difference between groups viz., Eating subscale, Appearance subscale, Sickness subscale but over all improvement in QOL was observed.
Conclusions
Submucosal dexamethasone effectively reduces postoperative sequelae and improves postoperative QOL after TMS.
Similar content being viewed by others
Abbreviations
- ASA:
-
American society of anesthesiologists (physical status classification system)
- CTG:
-
Control group
- DXG:
-
Dexamethasone group
- Fig:
-
Figure
- IIO:
-
Inter incisor opening
- POD:
-
Postoperative day
- PoSSe:
-
Postoperative symptoms and severity scale
- PONV:
-
Postoperative nausea and vomiting
- QOL:
-
Quality of life
- TMS:
-
Third molar surgery
- VAS:
-
Visual analog scale
- VAS1-7:
-
Total VAS score in a week
References
Pais-Ribeiro JL (2004) Quality of life is a primary end-point in clinical settings. Clin Nutr 23(1):121–130
McGrath C, Comfort MB, Lo EC, Luo Y (2003) Patient-centred outcome measures in oral surgery: validity and sensitivity. Br J Oral Maxillofac Surg 41(1):43–47
Ogden GR, Bissias E, Ruta DA, Ogston S (1998) Quality of life following third molar removal: a patient versus professional perspective. Br Dent J 185(8):407–410
Doward LC, McKenna SP (2004) Defining patient-reported outcomes. Value Health 7(Suppl 1):S4–S8
Kaplan RM (2003) The significance of quality of life in health care. Qual Life Res 12(Suppl 1):3–16
Swaine-Verdier A, Doward LC, Hagell P, Thorsen H, McKenna SP (2004) Adapting quality of life instruments. Value Health 7(Suppl 1):S27–S30
Colorado-Bonnin M, Valmaseda-Castellón E, Berini-Aytés L, Gay-Escoda C (2006) Quality of life following lower third molar removal. Int J Oral Maxillofac Surg 35:343–347
Markiewicz MR, Brady MF, Ding EL, Dodson TB (2008) Corticosteroids reduce postoperative morbidity after third molar surgery: a systematic review and meta-analysis. J Oral Maxillofac Surg 66(9):1881–1894
Antunes AA, Avelar RL, MartinsNeto EC, Frota R, Dias E (2011) Effect of two routes of administration of dexamethasone on pain, edema, and trismus in impacted lower third molar surgery. Oral Maxillofac Surg 15(4):217–223
Graziani F, D’Aiuto F, Arduino PG, Tonelli M, Gabriele M (2006) Perioperative dexamethasone reduces post-surgical sequelae of wisdom tooth removal. A split-mouth randomized double-masked clinical trial. Int J Oral Maxillofac Surg 35(3):241–246
Nobuhara WK, Carnes DL, Gilles JA (1993) Anti-inflammatory effects of dexamethasone on periapical tissues following endodontic overinstrumentation. J Endod 19(10):501–507
Mehrvarzfar P, Shababi B, Sayyad R, Fallahdoost A, Kheradpir K (2008) Effect of supraperiosteal injection of dexamethasone on postoperative pain. Aust Endod J 34(1):25–29
Grossi GB, Maiorana C, Garramone RA, Borgonovo A, Beretta M, Farronato D, Santoro F (2007) Effect of submucosal injection of dexamethasone on postoperative discomfort after third molar surgery: a prospective study. J Oral Maxillofac Surg 65(11):2218–2226
Majid OW, Mahmood WK (2011) Effect of submucosal and intramuscular dexamethasone on postoperative sequelae after third molar surgery: comparative study. Br J Oral Maxillofac Surg 49(8):647–652 (Epub 2010 Oct 29)
Deo SP, Shetty P (2011) Effect of submucosal injection of dexamethasone on post-operative sequelae of third molar surgery. J Nepal Med Assoc 51(182):72–78
Majid OW (2011) Submucosal dexamethasone injection improves quality of life measures after third molar surgery: a comparative study. J Oral Maxillofac Surg 69(9):2289–2297
Gersema L, Baker K (1992) Use of corticosteroids in oral surgery. J Oral Maxillofac Surg 50:270–277
Ruta DA, Bissias E, Ogston S, Ogden GR (2000) Assessing health outcomes after extraction of third molars: the postoperative symptom severity (PoSSe) scale. Br J Oral Maxillofac Surg 38(5):480–487
White RP Jr, Shugars DA, Shafer DM, Laskin DM, Buckley MJ, Phillips C (2003) Recovery after third molar surgery: clinical and health-related quality of life outcomes. J Oral Maxillofac Surg 61(5):535–544
Phillips C, Gelesko S, Proffit WR, White RP Jr (2010) Recovery after third-molar surgery: the effects of age and sex. Am J Orthod Dentofacial Orthop 138(6):700.e1–700.e8
McGrath C, Comfort MB, Lo EC, Luo Y (2003) Can third molar surgery improve quality of life? A 6-month cohort study. J Oral Maxillofac Surg 61(7):759–763
Sato FR, Asprino L, de Araujo DE, de Moraes M (2009) Short-term outcome of postoperative patient recovery perception after surgical removal of third molar. J Oral Maxillofac Surg 67(5):1083–1091
Shugars DA, Gentile MA, Ahmad N, Stavropoulos MF, Slade GD, Phillips C, Conrad SM, Fleuchaus PT, White RP Jr (2006) Assessment of oral health-related quality of life before and after third molar surgery. J Oral Maxillofac Surg 64(12):1721–1730
Sheldon TA, Cullum N, Dawson D, Lankshear A, Lowson K, Watt I, West P, Wright D, Wright J (2004) What’s the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients’ notes, and interviews. BMJ 329(7473):999
Dodson TB (2012) Surveillance as a management strategy for retained third molars: is it desirable? J Oral Maxillofac Surg 70(9 Suppl 1):S20–S24
Evan AW, Leeson RM, Petrie A (2005) Correlation between patients centered outcome score and surgical skill in oral surgery. Br J Oral Maxillofac Surg 43(6):505–510
Uva L, Migual D, Pinheiro C, Antunes J, Cruz D, Ferreira J, Filipe P (2012) Mechanisms of action of topical corticosteroids in psoriasis. Int J Endocrinol 2012:561018
Tiwana PS, Foy SP, Shugars DA, Marciani RD, Conrad SM, Phillips C, White RP (2005) The impact of intravenous corticosteroids with third molar surgery in patients at high risk for delayed health-related quality of life and clinical recovery. J Oral Maxillofac Surg 63(1):55–62
Negreiros RM, Biazevic MG, Jorge WA, Michel-Crosato E (2012) Relationship between oral health-related quality of life and the position of the lower third molar: postoperative follow-up. J Oral Maxillofac Surg 70(4):779–786
Bradshaw S, Faulk J, Blackey GH, Philips C, Phero JA, White RP Jr (2012) Quality of life outcome after third molar removal in subjects with minor symptoms of pericoronitis. J Oral Maxillofac Surg 70(11):2494–2500
Kaan MN, Odabasi O, Gezer E, Daldal A (2006) The effect of preoperative dexamethasone on early oral intake, vomiting and pain after tonsillectomy. Int J Pediatr Otorhinolaryngol 70(1):73–79
Acknowledgments
My heartfull thanks to Mrs Rachana Deo for her technical support.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None.
Rights and permissions
About this article
Cite this article
Deo, S.P. Single-Dose of Submucosal Injection of Dexamethasone Affects the Post Operative Quality of Life After Third Molar Surgery. J. Maxillofac. Oral Surg. 15, 367–375 (2016). https://doi.org/10.1007/s12663-015-0846-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12663-015-0846-6