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Effect of ZnO Doping on Biological Properties of SiO2-CaO-P2O5-SrO Bioactive Nanoglasses Synthesized via the Sol–Gel Method

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Abstract

The current research was done to evaluate the effect of zinc on the structural and biological characteristics of 58 s bioactive glasses. To this end, SiO2–CaO–P2O5–SrO–ZnO bioactive nanoglasses containing different content of ZnO (0, 1, 3, and 5 mol.%) were produced by the sol–gel process. To assess their bioactivity, the specimens were soaked in the simulated body fluid (SBF) solution for 21 days and analyzed employing Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), and scanning electron microscopy (SEM) techniques. The results indicated that the bioactive nanoglass sample containing 1 mol.% Zn possessed the highest potential in terms of hydroxyapatite formation. The results obtained by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay proved the superior biocompatibility of Zn-containing nanoglasses compared to Zn-free samples. Accordingly, the sample containing 1 mol.% Zn was considered a suitable candidate for medical applications.

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Acknowledgements

All authors would like to acknowledge the support of the Science and Research University of Technology for this research.

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Authors and Affiliations

  1. Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Tehran, Iran

    Negar Azizabadi, Parviz Aberoomand Azar & Mohammad Saber Tehrani

  2. Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Tehran, Iran

    Pirouz Derakhshi

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  1. Negar Azizabadi
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Negar Azizabadi: Methodology, Investigation. Parviz Aberoomand.

Azar: Supervision, Project administration. Mohammad Saber Tehrani: Writing—original draft. Pirouz Derakhshi: Writing—review & editing.

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Correspondence to Parviz Aberoomand Azar.

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Azizabadi, N., Azar, P.A., Tehrani, M.S. et al. Effect of ZnO Doping on Biological Properties of SiO2-CaO-P2O5-SrO Bioactive Nanoglasses Synthesized via the Sol–Gel Method. Silicon 15, 4835–4844 (2023). https://doi.org/10.1007/s12633-023-02399-2

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