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Silver Nanoparticles Derived from Probiotic Lactobacillus casei—a Novel Approach for Combating Bacterial Infections and Cancer

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Abstract

In the face of rising antibiotic resistance and the need for novel therapeutic approaches against cancer, the present study delves into the various facets of biosynthesized silver nanoparticles (AgNPs) derived from the probiotic strain Lactobacillus casei (AgNPs-LC), assessing their efficacy in combating bacterial infections, disrupting biofilm formation, interfering with quorum sensing mechanisms, and exhibiting anti-cancer properties. The results showed that the AgNPs-LC had a spherical shape with an average size of 15 nm. The biosynthesized AgNPs-LC showed a symmetrical absorption spectrum with a peak at 458 nm with a diameter of 5–20 nm. AgNPs-LC exhibited significant antibacterial activity against Gram-positive and Gram-negative bacteria and inhibited the biofilm formation (> 50% at sub-MIC) and quorum sensing-mediated virulence factors, such as the production of violacein in C. violaceum (> 80% at sub-MIC), pyocyanin in P. aeruginosa (> 70% at sub-MIC), and prodigiosin in S. marcescens (> 80% at sub-MIC). The exopolysaccharides (EPS) were also found to reduce in the presence of AgNPs-LC. Furthermore, the AgNPs-LC showed anti-cancer and anti-metastasis activity via inhibiting cell migration and invasion of human lung cancer (A-549) cells. Overall, the present study brings out the multifaceted therapeutic capabilities of AgNPs-LC which offer exciting prospects for the development of innovative biomedical and pharmaceutical interventions, making AgNPs-LC a versatile and promising candidate for a wide range of applications in healthcare and medicine. However, further research is essential to fully harness their therapeutic potential.

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Data Availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

I would like to thank and appreciate all the support and technical assistance provided by the Scientific Research Deanship at the University of Ha’il, Saudi Arabia, through project number RG-23049.

Funding

This research has been funded by the Scientific Research Deanship at the University of Ha’il, Saudi Arabia, through project number RG-23049.

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Authors and Affiliations

  1. Department of Biology, College of Science, University of Ha’il, P.O. Box 2440, Ha’il, Saudi Arabia

    Arif Jamal Siddiqui, Abdelmushin Abdelgadir, Mohammad Jahoor Alam, Riadh Badraoui & Mohd Adnan

  2. Research and Development Cell, Department of Biotechnology, Parul Institute of Applied Sciences, Parul University, Vadodara, 391760, India

    Mitesh Patel

  3. Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Al Majmaah, 11952, Saudi Arabia

    Sadaf Jahan & Wael Alturaiki

  4. Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, 1988, Najran, 61441, Saudi Arabia

    Mohammed Merae Alshahrani

  5. Department of Oral Radiology, College of Dentistry, University of Ha’il, P.O. Box 2440, Ha’il, Saudi Arabia

    Manojkumar Sachidanandan

  6. Department of Biosciences, Faculty of Science, Integral University, Lucknow, 22602, India

    Andleeb Khan

  7. Department of Pharmacology and Toxicology, College of Pharmacy, Jazan University, Jazan, 45142, Saudi Arabia

    Andleeb Khan

  8. Section of Histology-Cytology, Medicine Faculty of Tunis, University of Tunis El Manar, 1017 La Rabta, Tunis, Tunisia

    Riadh Badraoui

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  1. Arif Jamal Siddiqui
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Contributions

Conceptualization: A.J.S., M.P., and M.A.; methodology: M.M.A., W.A, S.J., M.K., M.J.A., and A.K.; validation, R.B., M.J.A, A.A., W.A., M.K., and S.J; formal analysis: M.A., R.B., M.M.A., A.K., M.P., M.K. and W.A.; investigation, M.M.A., A.K., R.B., W.A., A.A., and S.J.; data curation, M.M.A., M.J.A., A.K., M.P., A.A., W.A., M.K., and R.B.; writing—original draft preparation, A.J.S. M.P., and M.A.; writing—review and editing, A.J.S., M.P., M.A., and S.J.; visualization, A.A., A.B. M.A., and R.B.; supervision, A.J.S.; project administration, A.J.S. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Arif Jamal Siddiqui.

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Siddiqui, A.J., Patel, M., Jahan, S. et al. Silver Nanoparticles Derived from Probiotic Lactobacillus casei—a Novel Approach for Combating Bacterial Infections and Cancer. Probiotics & Antimicro. Prot. (2023). https://doi.org/10.1007/s12602-023-10201-3

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