Abstract
G protein-coupled receptors (GPCRs) comprise the largest family of integral membrane proteins that regulate many important physiological functions. Despite the extensive investigations on GPCRs, the effect of intermittent restraint stress and recovery on the major GPCRs in brain/gut axis is very limited. We thus hypothesized that GPCRs such as adrenergic, dopamine, serotonin and melatonin receptors in the segments of brain and gut might have involved during intermittent restraint stress and its recovery in mice. The mRNA abundance of 8 GPCR genes (adrenergic receptor beta 1 (Adrb1) and beta 2 (Adrb2), dopamine receptor1 (Drd1) and 2 (Drd2), serotonin receptor 1D (Htr1d) and 2B (Htr2b), melatonin receptor 1A (Mtnr1a) and 1B (Mtnr1b)) in the brain segments and gut of mice were analyzed after exposed to intermittent restraint stress and recovery. The qPCR analysis of these gene expression patterns in cortex, hippocampus and cerebellum of brain and anterior ileum of gut region of mice showed both spatial and differential pattern of mRNA abundance of GPCRs in restraint stressed mice. We found that activation of adrenergic receptors in the brain segments after intermittent restraint stress and activation of melatonin/serotonin receptors in gut of recovery mice. Our data thus support the hypothesis that a two-way neuroendocrine communication exists between brain/gut axis of mice during restraint stress and its recovery where activation of adrenergic, dopamine, melatonin and serotonin receptor systems seems to be essential during stress and ease response.
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Acknowledgements
The authors thank iCEIB Project in the University of Kerala funded by Higher Education Department of Government of Kerala during 2017-22. Indu B Nair acknowledges the CSIR-UGC, New Delhi for providing Junior and Senior Research Fellowships (Student ID: 321995).
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Nair, I.B., Manish, K. & Peter, M.C.S. Intermittent Restraint Stress and Recovery on GPCR Expression in Brain/Gut Axis of Mice: Activation of Adrenergic, Dopamine, Serotonin and Melatonin Receptors During Stress and Ease Response. Proc Zool Soc 77, 58–74 (2024). https://doi.org/10.1007/s12595-023-00508-y
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DOI: https://doi.org/10.1007/s12595-023-00508-y