Abstract
Purpose
This article acts as an introduction to the challenges involved in the development of a code of practice for the dosimetry of BNCT beams. It seeks to identify the key components that would require consensus agreement including the appropriate reference conditions and a selection of potentially suitable technologies.
Methods
The article draws on the extensive experience of the authors in dosimetry applied to BNCT beams. The highly complex radiation field and mix of dose components that varies with depth in phantom brings specific challenges. Overall BNCT requires approaches to dosimetry that have some commonalities with other radiotherapy modalities, but also some areas of considerable difference. The requirement for a code of practice to manage this novel situation is identified, along with the requirement to accommodate methodologies and technologies that have already achieved a degree of acceptance in sections of the BNCT community.
Results
Provisional guidance is provided on the scope of a Code of Practice for BNCT beams, and on approaches to manage the unique characteristics of the delivered dose and the mix of dose components. The relatively unique role of full transport simulations in BNCT is also highlighted as an area of difference with more established radiotherapy modalities. The particular challenge of accurate dosimetry for the fast neutron component at the patient surface is identified.
Conclusions
The need for broadly-based community support for a code of practice is identified. The next stage of development of this project will require the mobilisation of a group of experts from within the BNCT community and also from dosimetry experts more familiar with conventional radiotherapy.
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References
Munck af, Rosenschold P, et al. Photon quality correction factors for ionization chambers in an epithermal neutron beam. Phys Med Biol. 2002;47:2397–409.
Hirose K, et al. Determining a methodology of dosimetric quality assurance for commercially available accelerator-based boron neutron capture therapy system. J Radiat Res. 2022;63:620–35. https://doi.org/10.1093/jrr/rrac030.
Kumada H, et al. Evaluation of the characteristics of the neutron beam of a linac-based neutron source for boron neutron capture therapy. Appl Radiation Isot. 2020;165. https://doi.org/10.1016/j.apradiso.2020.109246.
Voorbraak W et al. 2003, Recommendations for the Dosimetry of Boron Neutron Capture Therapy (BNCT) Petten, 1 December 2003, NRG Report 21425/03.55339/C.
Rogus DR, Harling OK, Yanch JC. Mixed field dosimetry of epithermal neutron beams for boron neutron capture therapy at the MITR-II research reactor. Med Phys. 1994;21(10):1611–25.
Sakurai Y, Kobayashi T. Characteristics of the KUR Heavy Water Neutron Irradiation Facility as a neutron irradiation field with variable energy spectra. Nucl Instrum Methods Phys Res Sect A. 2000;453(3):21–569.
International Atomic Energy Agency. Advances in Boron Neutron capture Therapy. Vienna: Non-serial Publications, IAEA; 2023.
Acknowledgements
The authors would like to thank Dr Ben Phoenix who performed the simulations providing data for Fig. 1 of this paper, which is used here to illustrate the general trends in the different dose components in a BNCT beam.
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Contributions
Material preparation, data collection and analysis were performed by Stuart Green. The first draft of the manuscript was written by Stuart Green and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Authors S. Green and H. Kumada declare they have no financial interests. Author H. Koivunoro is employed by Neutron Therapeutics.
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Green, S., Koivunoro, H. & Kumada, H. Considerations for a dosimetry code of practice for BNCT. Health Technol. (2024). https://doi.org/10.1007/s12553-024-00852-9
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DOI: https://doi.org/10.1007/s12553-024-00852-9