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Liver metastases of colorectal adenocarcinoma with intrahepatic biliary spread pattern: clinical manifestation and importance of immunohistochemical analysis

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Abstract

Liver metastases of colorectal carcinoma (LMCC) with macroscopic intrabiliary ductal involvement are a rare entity that can clinically and radiologically mimic a cholangiocarcinoma. However, a thorough anatomopathologic and immunohistochemical study of biliary ductal involvement is required because of its distinctive clinical features and relatively indolent biological behavior, reflecting a better prognosis and long-term survival. We present the case of a patient who debuted with LMCC with intrahepatic biliary ductal involvement, whose definitive diagnosis was established by immunohistochemical analysis, showing a characteristic CK7 − /CK20 + pattern.

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Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of General Surgery, Hospital Universitario Rey Juan Carlos, Calle Gladiolo S/N, 28933, Móstoles, Madrid, Spain

    Tamara Díaz Vico, Camilo José Castellón Pavón, Gustavo Adolfo Díaz García, Ana Torres Alemán, María Teresa Pérez Domene, Silvia Sánchez Infante & Manuel Durán Poveda

  2. Department of Pathological Anatomy, Hospital Universitario Rey Juan Carlos, Madrid, Spain

    Daniela Carolina Fuel Gómez

Authors
  1. Tamara Díaz Vico
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  2. Camilo José Castellón Pavón
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  3. Gustavo Adolfo Díaz García
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  4. Ana Torres Alemán
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  5. María Teresa Pérez Domene
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  6. Silvia Sánchez Infante
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  7. Daniela Carolina Fuel Gómez
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  8. Manuel Durán Poveda
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Contributions

Study conception and design: TDV. Acquisition of data: CJCP, GADG, ATA, and DCFG. Drafting the manuscript: TDV, MTPD, and SSI. Critical review of the manuscript for important intellectual content: CJCP and MDP. Manuscript supervision: CJCP. Approval of the version to be published: all authors.

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Correspondence to Tamara Díaz Vico.

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Díaz Vico, T., Castellón Pavón, C.J., Díaz García, G.A. et al. Liver metastases of colorectal adenocarcinoma with intrahepatic biliary spread pattern: clinical manifestation and importance of immunohistochemical analysis. Clin J Gastroenterol 16, 693–697 (2023). https://doi.org/10.1007/s12328-023-01819-5

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  • DOI: https://doi.org/10.1007/s12328-023-01819-5

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