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A case of eosinophilic esophagitis with autoimmune polyendocrine syndrome type 2, including autoimmune gastritis

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Abstract

Both eosinophilic esophagitis (EoE) and autoimmune polyendocrine syndrome (APS) are relatively rare diseases in Japan. We herein report a case of EoE with APS in a 67-year-old Japanese man who presented with chest pain and dysphagia. On the basis of endoscopic findings and histological analysis, we diagnosed the patient with EoE along with autoimmune gastritis. Additional serological examinations revealed the presence of Hashimoto’s thyroiditis and type 1 diabetes, which led to the final diagnosis of APS. His symptoms did not respond to treatment with a proton-pump inhibitor but improved with topical steroid therapy. This case of coexisting EoE and APS-2 is quite rare and has several implications for the pathogenesis of both conditions.

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Acknowledgements

We thank Edanz Group (https://en-author-services.edanzgroup.com/ac) for editing a draft of this manuscript.

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All authors disclose no financial relationships relevant to this publication. The authors received no specific funding for this article.

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Authors and Affiliations

  1. Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, 2-6-1, Nakasange, Kita-ku, Okayama, 700-8505, Japan

    Maki Ayaki, Noriaki Manabe, Minoru Fujita & Jun Nakamura

  2. Department of Health Care Medicine, Kawasaki Medical School, Okayama, Japan

    Aya Sunago & Tomoari Kamada

  3. Division of Gastroenterology, Department of Internal Medicine 2, Kawasaki Medical School, Okayama, Japan

    Ken Haruma

Authors
  1. Maki Ayaki
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  2. Noriaki Manabe
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  3. Minoru Fujita
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  4. Jun Nakamura
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  5. Aya Sunago
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  6. Tomoari Kamada
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  7. Ken Haruma
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Correspondence to Maki Ayaki.

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Ayaki, M., Manabe, N., Fujita, M. et al. A case of eosinophilic esophagitis with autoimmune polyendocrine syndrome type 2, including autoimmune gastritis. Clin J Gastroenterol 14, 460–465 (2021). https://doi.org/10.1007/s12328-020-01333-y

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  • DOI: https://doi.org/10.1007/s12328-020-01333-y

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