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Esophagogastric varices were diagnosed in a non-cirrhotic liver case during long-term follow-up after oxaliplatin-based chemotherapy

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Abstract

Oxaliplatin, a chemotherapeutic agent for colorectal cancer, has been associated with pathological evidence of sinusoidal endothelial injury in the liver. However, esophagogastric varices are a poorly recognized outcome of oxaliplatin-based chemotherapy. We report a 78-year-old man, whose past history of colon cancer was resection and treatment with mFOLFOX6 for 20 weeks, as adjuvant chemotherapy. After 3.5-year follow-up of the oxaliplatin-based chemotherapy, he was diagnosed with esophageal varices without liver dysfunction, indicating that the hepatotoxicity caused by oxaliplatin could be prolonged after its administration. Patients who have received oxaliplatin-based chemotherapy should be followed up carefully over the long term.

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Acknowledgements

This study was supported, in part, by a grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan, and a grant-in-aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

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Authors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan

    Ryuta Shigefuku, Tsunamasa Watanabe, Kotaro Matsunaga, Nobuhiro Hattori, Takuya Ehira, Tatsuya Suzuki, Hiroyasu Nakano, Yoshinori Sato, Yasumasa Matsuo, Kazunari Nakahara, Hiroki Ikeda, Nobuyuki Matsumoto, Hiroshi Yasuda & Fumio Itoh

  2. Department of Clinical Oncology, St. Marianna University, Kawasaki, Japan

    Takuro Mizukami, Takashi Tsuda & Takako Eguchi Nakajima

  3. Division of Gastroenterological and General Surgery, St. Marianna University, Kawasaki, Japan

    Masafumi Katayama, Satoshi Koizumi & Takehito Otsubo

  4. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital, Kawasaki, Japan

    Chiaki Okuse & Michihiro Suzuki

Authors
  1. Ryuta Shigefuku
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  2. Tsunamasa Watanabe
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  3. Takuro Mizukami
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  4. Kotaro Matsunaga
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  5. Nobuhiro Hattori
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  6. Takuya Ehira
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  7. Tatsuya Suzuki
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  8. Hiroyasu Nakano
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  9. Yoshinori Sato
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  10. Yasumasa Matsuo
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  11. Kazunari Nakahara
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  12. Hiroki Ikeda
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  13. Nobuyuki Matsumoto
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  16. Satoshi Koizumi
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  17. Chiaki Okuse
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  18. Michihiro Suzuki
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  19. Takehito Otsubo
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  20. Takako Eguchi Nakajima
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  21. Hiroshi Yasuda
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  22. Fumio Itoh
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Corresponding author

Correspondence to Tsunamasa Watanabe.

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Shigefuku, R., Watanabe, T., Mizukami, T. et al. Esophagogastric varices were diagnosed in a non-cirrhotic liver case during long-term follow-up after oxaliplatin-based chemotherapy. Clin J Gastroenterol 11, 487–492 (2018). https://doi.org/10.1007/s12328-018-0873-1

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  • DOI: https://doi.org/10.1007/s12328-018-0873-1

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