Abstract
A 16-year-old girl presented to our hospital with diarrhea and abdominal pain. The macroscopic findings of colonoscopy revealed multiple submucosal tumors and multiple ulcers, which were localized in the sigmoid colon, and diffuse granular mucosa which extended to the total colon. The pathological diagnosis was malignant lymphoma comprising both components of diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue (MALT) lymphoma, because the large lymphoma cells were CD20+, CD10−, and CD5−. Furthermore, immunohistochemical analysis of colorectal biopsy samples from multiple ulcers revealed cytomegalovirus (CMV)-positive cells. The patient was diagnosed with primary colorectal lymphoma comprising both components of DLBCL and MALT lymphoma combined with CMV colitis. She received anti-viral medication and chemotherapy.
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Ryo Katsumata, Hiroshi Matsumoto, Osawa Motoyasu, Takahisa Murao, Manabu Ishii, Minoru Fujita, Hirotoshi Tokunaga, Takashi Akiyama, Hideho Wada, Takashi Sugihara, Akiko Shiotani, and Ken Haruma declare that they have no conflict of interest.
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All procedures followed were performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
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Informed consent was obtained from the patient for inclusion in the study.
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Katsumata, R., Matsumoto, H., Motoyasu, O. et al. Primary colorectal lymphoma comprising both components of diffuse large B-cell lymphoma and mucosa-associated lymphoid tissue lymphoma combined with cytomegalovirus colitis . Clin J Gastroenterol 9, 59–62 (2016). https://doi.org/10.1007/s12328-016-0642-y
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DOI: https://doi.org/10.1007/s12328-016-0642-y