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Antidyslipidemic and Antioxidant Activities of Tinospora cordifolia Stem Extract in Alloxan Induced Diabetic Rats

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Abstract

The antidyslipidemic activities of Tinospora cordifolia (T. cordifolia): family Menispermaceae, Hindi name: Giloya; Gurch or Tinospora in english, extract have been studied in alloxan induced diabetic rats. In this model, oral administration of stem extract (500 mg/kg bw. p.o.) for 30 days resulted significant decreased in the levels of blood glucose, plasma lipids and reactivated post heparin lipoprotein lipase activity in alloxan induced diabetic rats. Furthermore, the stem extract (50–500 μg) when tested for its antioxidant activity, shown to inhibit the generation of super oxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems in vitro. The results of the present study demonstrated antidyslipidemic and antioxidant activities of T. cordifolia which could help in prevention of diabetic-dyslipidemia and related complications.

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Authors and Affiliations

  1. Department of Biochemistry, Era’s Lucknow Medical College & Hospital, Sarfarazganj, Hardoi Road, Lucknow, 226003, India

    Vishnu Kumar

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  1. Vishnu Kumar
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Correspondence to Vishnu Kumar.

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Kumar, V. Antidyslipidemic and Antioxidant Activities of Tinospora cordifolia Stem Extract in Alloxan Induced Diabetic Rats. Ind J Clin Biochem 30, 473–478 (2015). https://doi.org/10.1007/s12291-015-0485-1

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  • DOI: https://doi.org/10.1007/s12291-015-0485-1

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