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The Prevalence of Pulmonary Arterial Hypertension in Patients with Beta Thalassemia Major

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Abstract

Pulmonary arterial hypertension (PAH) remains a concern in patients with Beta thalassemia major (TM). However, this study aims to investigate the prevalence of PAH in TM patients in Kerman City placed in the south of Iran. In this cross-sectional study on 271 IranianBeta-thalassemia patients (mean age 19.8 \(\pm \) 7.9 in the range 10–60), Age, sex, weekly deferral taking, the number of blood transfusion in a month, and last echocardiography report data was gathered from every patient's file. SPSS for Windows (version 21) was used for analysis. According to the results, the prevalence of PAH was 10.3% (28 patients). PAH had significant associations with weekly deferral consumption (P = 0.028), ferritin serum level (P = 0.001), and ejection fraction (EF) (P = 0.001). PAH is positively associated with deferral consumption and is negatively associated with EF (respectively, P = 0.031, P = 0.001). It is very important to consider prevention and treatment for decreasing the mortality and morbidity of PAH patients in health planning and policy.

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Acknowledgements

We thank the people who participated in the study, the study-site personnel, and members of the Samen al-Hujjaj health center, Kerman, Iran.

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Authors and Affiliations

  1. Cardiovascular Research Center, Institute of Basic and Clinical Physiology Science, Kerman University of Medical Science, Kerman, Iran

    Masoumeh Kahnoji

  2. Department of Epidemiology, Iran University of Medical Sciences, Tehran, Iran

    Saeid Bitaraf

  3. Physiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

    Narjes Soltani

  4. Shariati Hospital, Tehran University of Medical Science, Tehran, Iran

    Hamidreza Esmaeili-Nadimi

Authors
  1. Masoumeh Kahnoji
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  2. Saeid Bitaraf
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  3. Narjes Soltani
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  4. Hamidreza Esmaeili-Nadimi
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Contributions

MK Contributed to the design of the study, analysis, and drafting of the manuscript. HE contributed to data collection, and drafting of the manuscript. SB contributed to data collection, and drafting of the manuscript. NS contributed to a critical review of the draft manuscript. MK and HE contributed to the design of the study, data collection, and critical review of the draft manuscript. All authors read and approved the final manuscript.

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Correspondence to Hamidreza Esmaeili-Nadimi.

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Kahnoji, M., Bitaraf, S., Soltani, N. et al. The Prevalence of Pulmonary Arterial Hypertension in Patients with Beta Thalassemia Major. Indian J Hematol Blood Transfus 40, 74–77 (2024). https://doi.org/10.1007/s12288-023-01678-7

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  • DOI: https://doi.org/10.1007/s12288-023-01678-7

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