Skip to main content

Advertisement

Log in

A Case of Primary Bone Marrow B-Cell Non Hodgkin’s Lymphoma with Severe Thrombocytopenia: Case Report and A Review of the Literature

  • Case Report
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

A 78-year-old man presented with persistent gingival bleeding. He had low platelet count of 1.0 × 109/L without any lymphadenopathy. Bone marrow specimen showed diffusely distributed small-sized lymphocytes. Combined with immunophenotypic analysis, a diagnosis of primary bone marrow B-cell non-Hodgkin’s lymphoma was made. Thrombocytopenia was considered to be caused by autoimmune destruction of platelets.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Conlan MG, Bast M, Armitage JO, Weisenburger DD (1990) Bone marrow involvement by non-Hodgkin’s lymphoma: the clinical significance of morphologic discordance between the lymph node and bone marrow. Nebraska Lymphoma Study Group. J Clin Oncol 8:1163–1172

    CAS  PubMed  Google Scholar 

  2. Newton R, Ferlay J, Beral V, Devesa SS (1997) The epidemiology of non-Hodgkin’s lymphoma: comparison of nodal and extra-nodal sites. Int J Cancer 17:923–930

    Article  Google Scholar 

  3. Hassan K, Nagi AH, Hayee A (1982) Non-Hodgkin’s lymphoma of bone marrow—an unusual presentation. JPMA 32:230–236

    CAS  Google Scholar 

  4. Barton JC, Conrad ME, Vogler LB, Parmley RT (1980) Isolated marrow lymphoma: an entity of possible T-cell derivation. Cancer 46:1767–1774

    Article  CAS  PubMed  Google Scholar 

  5. Ponzoni M, Li C-Y (1994) Isolated bone marrow Non-Hodgkin’s lymphoma: a clinicopathologic study. Mayo Clin Proc 69:37–43

    CAS  PubMed  Google Scholar 

  6. Chachashvili S, Almoznino-Sarafian D, Yona R, Sandbank J, Shteinshnaider M, Modai D et al (2003) Isolated bone marrow non-Hodgkin’s lymphoma. Report of two cases and literature review. Eur J Intern Med 14:116–119

    Article  PubMed  Google Scholar 

  7. Strauchen JA (2003) Primary bone marrow B-cell lymphoma: report of four cases. Mt Sinai J Med 70:133–138

    PubMed  Google Scholar 

  8. Alvares CL, Matutes E, Scully MA, Swansbury J, Min T, Gruszka-Westwood AM et al (2004) Isolated bone marrow involvement in diffuse large B cell lymphoma: a report of three cases with review of morphological, immunophenotypic and cytogenetic findings. Leuk Lymphoma 45:769–775

    Article  PubMed  Google Scholar 

  9. Hauswirth AW, Skrabs C, Schützinger C, Raderer M, Chott A, Valent P et al (2008) Autoimmune thrombocytopenia in non-Hodgkin’s lymphomas. Haematologica 93:447–450

    Article  PubMed  Google Scholar 

  10. Foucar K, McKenna RW, Frizzera G, Brunning RD (1982) Bone marrow and blood involvement by lymphoma in relationship to the Lukes–Collins classification. Cancer 49:888–897

    Article  CAS  PubMed  Google Scholar 

  11. Arber DA, George TI (2005) Bone marrow biopsy involvement by non-Hodgkin’s lymphoma: frequency of lymphoma types, patterns, blood involvement, and discordance with other sites in 450 specimens. Am J Surg Pathol 29:1549–1557

    Article  PubMed  Google Scholar 

  12. Torlakovic E, Torlakovic G, Brunning RD (2002) Follicular pattern of bone marrow involvement by follicular lymphoma. Am J Clin Pathol 118:780–786

    Article  PubMed  Google Scholar 

  13. Amakawa R, Fukuhara S, Ohno H, Doi S, Oguma S, Tanabe S et al (1989) Involvement of bcl-2 gene in Japanese follicular lymphoma. Blood 73:787–791

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Yuki Kagoya.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kagoya, Y., Sahara, N., Matsunaga, T. et al. A Case of Primary Bone Marrow B-Cell Non Hodgkin’s Lymphoma with Severe Thrombocytopenia: Case Report and A Review of the Literature. Indian J Hematol Blood Transfus 26, 106–108 (2010). https://doi.org/10.1007/s12288-010-0040-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-010-0040-4

Keywords

Navigation