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Cationic engineered nanodiamonds for efficient antibacterial surface with strong wear resistance

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Abstract

The spread of diseases caused by bacterial adhesion and immobilization in public places constitutes a serious threat to public health. Prevention of bacteria spread by the construction of an antibacterial surface takes precedence over post-infection treatment. Herein, we demonstrate an effective antibacterial surface with strong wear resistance by constructing cationic engineered nanodiamonds (C-NDs). The C-NDs with positive surface potentials interact effectively with bacteria through electrostatic interactions, where the C-NDs act on the phospholipid bilayer and lead to bacterial membrane collapse and rupture through hydrogen bonding and residual surface oxygen-containing reactive groups. In this case, bactericidal rate of 99.99% and bacterial biofilm inhibition rate of more than 80% can be achieved with the C-NDs concentration of 1 mg/mL. In addition, the C-NDs show outstanding antibacterial stability, retaining over 87% of the antibacterial effect after stimulation by adverse environments of heat, acid, and external abrasion. Therefore, an antibacterial surface with high wear resistance obtained by integrating C-NDs with commercial plastics has been demonstrated. The antibacterial surface with a mass fraction of 1 wt.% C-NDs improved abrasion resistance by 3981 times, with 99% killing of adherent bacteria. This work provides an effective strategy for highly efficient antibacterial wear-resistant surface, showing great practical applications in public health environments.

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Acknowledgements

The authors acknowledge the National Natural Science Foundation of China (Nos. 12274378, 62075198 and U21A2070), Outstanding Youth Foundation of Henan (No. 222300420087) for financial support of this work.

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  1. Fu-Kui Li and Wen-Bo Zhao contributed equally to this work.

Authors and Affiliations

  1. Henan Key Laboratory of Diamond Optoelectronic Materials and Devices, Key Laboratory of Materials Physics, Ministry of Education, and School of Physics & Microelectronics, Zhengzhou University, Zhengzhou, 450052, China

    Fu-Kui Li, Wen-Bo Zhao, Yong Wang, Wen-Tao Huang, Ya-Lun Ku, Hang Liu, Rui Guo, Hui-Hui Yu, Kai-Kai Liu & Chong-Xin Shan

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  1. Fu-Kui Li
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Correspondence to Kai-Kai Liu or Chong-Xin Shan.

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Li, FK., Zhao, WB., Wang, Y. et al. Cationic engineered nanodiamonds for efficient antibacterial surface with strong wear resistance. Nano Res. 17, 939–948 (2024). https://doi.org/10.1007/s12274-024-6417-8

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