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Pathological and therapeutic roles of innate lymphoid cells in diverse diseases

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Abstract

Innate lymphoid cells (ILCs) are a recently defined type of innate-immunity cells that belong to the lymphoid lineage and have lymphoid morphology but do not express an antigen-specific B cell or T-cell receptor. ILCs regulate immune functions prior to the formation of adaptive immunity and exert effector functions through a cytokine release. ILCs have been classified into three groups according to the transcription factors that regulate their development and function and the effector cytokines they produce. Of note, ILCs resemble T helper (Th) cells, such as Th1, Th2, and Th17 cells, and show a similar dependence on transcription factors and distinct cytokine production. Despite their short history in immunology, ILCs have received much attention, and numerous studies have revealed biological functions of ILCs including host defense against pathogens, inflammation, tissue repair, and metabolic homeostasis. Here, we describe recent findings about the roles of ILCs in the pathogenesis of various diseases and potential therapeutic targets.

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Acknowledgements

This work was supported by the National Research Foundation (NRF), funded by the Ministry of Science, ICT, and Future Planning [2015R1C1A2A01054457 to H.M.].

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  1. College of Pharmacy, Chung-Ang University, 84 Heukseokro, Dongjakgu, Seoul, 06974, Korea

    Jisu Kim, Geon Kim & Hyeyoung Min

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Kim, J., Kim, G. & Min, H. Pathological and therapeutic roles of innate lymphoid cells in diverse diseases. Arch. Pharm. Res. 40, 1249–1264 (2017). https://doi.org/10.1007/s12272-017-0974-2

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