Abstract
Bioassay-guided fractionation of the MeOH extract of Magnolia grandiflora seeds resulted in the isolation of a new dimeric neolignan, named bishonokiol A (1), as well as two known neolignans magnolol (2) and honokiol (3). The structures of the compounds were determined on the basis of data obtained using NMR and MS. Bishonokiol A (1) showed potent anti-proliferative activities in four human cancer cell lines, with IC50 values ranging from 5.1 to 7.5 µM. Additionally, bishonokiol A (1) induced apoptosis, as well as down-regulated the expression of the anti-apoptotic protein Bcl-2 and caspase-3 cleavage in HepG2 cell line.
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This work was financially supported by the National Natural Science Foundation of China under Grant (no. 81302671, 81372899); the Natural Science Foundation of Anhui Province under Grant (no. 1408085QH162); the Natural Science Foundation of Bengbu Medical College under Grant (Bykf1326).
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Hong-Mei Li and Su-Rong Zhao have contributed equally to this work.
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Li, HM., Zhao, SR., Huo, Q. et al. A new dimeric neolignan from Magnolia grandiflora L. seeds. Arch. Pharm. Res. 38, 1066–1071 (2015). https://doi.org/10.1007/s12272-014-0476-4
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DOI: https://doi.org/10.1007/s12272-014-0476-4