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Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities

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Abstract

In our screening for antitubercular agents, five naphtho-γ-pyrones including two new naphtho-γ-pyrones glycosides, indigotides G and H (1 and 2), and two diphenyl ethers were isolated from the extract of a sponge-derived fungus Metarhizium anisopliae mxh-99. Their structures were established on the basis of chemical and spectroscopic evidence. The antitubercular activities of all the compounds were evaluated against Mycobacterium phlei. The known isochaetochromin B2 (6) and ustilaginoidin D (7) exhibited the highest activity with MICs 50.0 μg/mL.

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Acknowledgments

This work was supported by the Chinese National Science Fund (No. 41176120), Promotive Research Fund for Excellent Young and Middle-aged Scientists of Shandong Province (No. BS2010HZ027), Specialized Research Fund for the Doctoral Program of Higher Education (No. 20100132120026), the Public Projects of State Oceanic Administration (No. 2010418022-3), and the Program for Changjiang Scholars and Innovative Research Team in University (No. IRT0944).

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Authors and Affiliations

  1. Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, People’s Republic of China

    Xianglan Kong, Xinhua Ma, Shengxin Cai, Tianjiao Zhu, Qianqun Gu & Dehai Li

  2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, People’s Republic of China

    Yunying Xie

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  1. Xianglan Kong
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  2. Xinhua Ma
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  3. Yunying Xie
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  4. Shengxin Cai
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  5. Tianjiao Zhu
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  6. Qianqun Gu
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  7. Dehai Li
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Correspondence to Dehai Li.

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Kong, X., Ma, X., Xie, Y. et al. Aromatic polyketides from a sponge-derived fungus Metarhizium anisopliae mxh-99 and their antitubercular activities. Arch. Pharm. Res. 36, 739–744 (2013). https://doi.org/10.1007/s12272-013-0077-7

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  • DOI: https://doi.org/10.1007/s12272-013-0077-7

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