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A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.

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Abstract

One new C29 sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC50 in the range of 12.8–27.8 μM.

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Authors and Affiliations

  1. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam

    Nguyen Huu Tung, Chau Van Minh, Phan Van Kiem, Hoang Thanh Huong, Tran Thu Ha, Nguyen Tien Dat, Nguyen Xuan Nhiem & Nguyen Xuan Cuong

  2. College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea

    Nguyen Huu Tung, Nguyen Xuan Nhiem & Young Ho Kim

  3. School of Medicine, Institute of Medical Sciences, Jeju National University, Jeju, 690-756, Korea

    Jae-Hee Hyun & Hee-Kyoung Kang

Authors
  1. Nguyen Huu Tung
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  2. Chau Van Minh
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  3. Phan Van Kiem
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  4. Hoang Thanh Huong
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  5. Tran Thu Ha
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  6. Nguyen Tien Dat
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  7. Nguyen Xuan Nhiem
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  8. Nguyen Xuan Cuong
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  9. Jae-Hee Hyun
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  10. Hee-Kyoung Kang
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  11. Young Ho Kim
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Correspondence to Young Ho Kim.

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Tung, N.H., Van Minh, C., Van Kiem, P. et al. A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.. Arch. Pharm. Res. 32, 1695–1698 (2009). https://doi.org/10.1007/s12272-009-2205-y

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  • DOI: https://doi.org/10.1007/s12272-009-2205-y

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