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Functional Striatal Abnormalities: A Distinct Brain Signature of Schizophrenia

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References

  1. Tsuang MT, Lyons MJ, Faraone SV. Heterogeneity of schizophrenia. Conceptual models and analytic strategies. Br J Psychiatry 1990, 156: 17–26.

    Article  CAS  Google Scholar 

  2. Li A, Zalesky A, Yue W, Howes O, Yan H, Liu Y, et al. A neuroimaging biomarker for striatal dysfunction in schizophrenia. Nat Med 2020, 26: 558–565.

    Article  CAS  Google Scholar 

  3. Sarpal DK, Robinson DG, Lencz T, Argyelan M, Ikuta T, Karlsgodt K, et al. Antipsychotic treatment and functional connectivity of the striatum in first-episode schizophrenia. JAMA Psychiatry 2015, 72: 5–13.

    Article  Google Scholar 

  4. Sarpal DK, Argyelan M, Robinson DG, Szeszko PR, Karlsgodt KH, John M, et al. Baseline striatal functional connectivity as a predictor of response to antipsychotic drug treatment. Am J Psychiatry 2016, 173: 69–77.

    Article  Google Scholar 

  5. Ehrlich S, Yendiki A, Greve DN, Manoach DS, Ho BC, White T, et al. Striatal function in relation to negative symptoms in schizophrenia. Psychol Med 2012, 42: 267–282.

    Article  CAS  Google Scholar 

  6. Howes OD, Nour MM. Dopamine and the aberrant salience hypothesis of schizophrenia. World Psychiatry 2016, 15: 3–4.

    Article  Google Scholar 

  7. Kapur S. Psychosis as a state of aberrant salience: a framework linking biology, phenomenology, and pharmacology in schizophrenia. Am J Psychiatry 2003, 160: 13–23.

    Article  Google Scholar 

  8. Brugger SP, Angelescu I, Abi-Dargham A, Mizrahi R, Shahrezaei V, Howes OD. Heterogeneity of striatal dopamine function in schizophrenia: Meta-analysis of variance. Biol Psychiatry 2020, 87: 215–224.

    Article  CAS  Google Scholar 

  9. White TP, Wigton R, Joyce DW, Collier T, Fornito A, Shergill SS. Dysfunctional striatal systems in treatment-resistant schizophrenia. Neuropsychopharmacology 2016, 41: 1274–1285.

    Article  CAS  Google Scholar 

  10. Koblan KS, Kent J, Hopkins SC, Krystal JH, Cheng H, Goldman R, et al. A Non-D2-receptor-binding drug for the treatment of schizophrenia. N Engl J Med 2020, 382: 1497–1506.

    Article  CAS  Google Scholar 

  11. Suckling J, Barnes A, Job D, Brenan D, Lymer K, Dazzan P, et al. Power calculations for multicenter imaging studies controlled by the false discovery rate. Hum Brain Mapp 2010, 31: 1183–1195.

    PubMed  PubMed Central  Google Scholar 

  12. Brandl F, Avram M, Weise B, Shang J, Simoes B, Bertram T, et al. Specific substantial dysconnectivity in schizophrenia: A transdiagnostic multimodal meta-analysis of resting-state functional and structural magnetic resonance imaging studies. Biol Psychiatry 2019, 85: 573–583.

    Article  Google Scholar 

  13. Karcher NR, Rogers BP, Woodward ND. Functional connectivity of the striatum in schizophrenia and psychotic bipolar disorder. Biol Psychiatry Cogn Neurosci Neuroimaging 2019, 4: 956–965.

    PubMed  PubMed Central  Google Scholar 

  14. Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, et al. A test of the transdiagnostic dopamine hypothesis of psychosis using positron emission tomographic imaging in bipolar affective disorder and schizophrenia. JAMA Psychiatry 2017, 74: 1206–1213.

    Article  Google Scholar 

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Acknowledgements

This highlight article was supported by the National Natural Science Foundation of China (81630030, 81920108018, and 81801326) and the 1.3.5 Project for Disciplines of Excellence, West China Hospital of Sichuan University (ZY2016103, ZY2016203, and ZYGD20004).

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Authors and Affiliations

  1. Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China

    Sugai Liang & Tao Li

  2. West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu, 610041, China

    Sugai Liang & Tao Li

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  1. Sugai Liang
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  2. Tao Li
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Correspondence to Tao Li.

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Liang, S., Li, T. Functional Striatal Abnormalities: A Distinct Brain Signature of Schizophrenia. Neurosci. Bull. 37, 284–286 (2021). https://doi.org/10.1007/s12264-020-00598-0

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  • DOI: https://doi.org/10.1007/s12264-020-00598-0

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