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Debridement using Piezosurgical Device and Incorporation of Autologous Platelet-Rich Fibrin in Management of Stage III Medication-Related Osteonecrosis of the Jaw — A Case study and Review of Literature

  • Surgical Techniques and Innovations
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Abstract

Medication-related osteonecrosis of the jaw (MRONJ) is a condition of persistent exposure of bone or an introral/extraoral fistula through which the bone can be probed for more than 8 weeks in a patient who is under treatment with antiresorptive or antiangiogenic agents (bisphosphonates, denosumab, antiangiogenic agents, tyrosine kinase inhibitors, and monoclonal antibody targeting vascular endothelial growth factors) in the maxillofacial region without any previous history radiation therapy to the jaws or obvious metastatic disease to the jaws. High index of suspicion is required to identify this entity and treat them accordingly. We hereby present a case report where we highlighted the methods to establish the diagnosis of medication-related osteonecrosis of the jaw and its complex management from medical management to surgical management with debridement using piezosurgical device along with the incorporation of autologous platelet concentrate and review the literature of this entity.

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Authors and Affiliations

  1. Department of Prosthodontics and Surgical Oncology, SMS Medical College and Hospital, Jaipur, Rajasthan, India

    Aishwarya Chatterjee, Manish Sahni, Suresh Singh, Sandeep Jain & Sandeep Jasuja

  2. Department of Surgical Oncology, M.G Medical College, Jaipur, Rajasthan, India

    Rajgovind Sharma

  3. Department of Medicine, Rajasthan University of Health Sciences, Jaipur, Rajasthan, India

    Sudhir Bhandari

Authors
  1. Aishwarya Chatterjee
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  2. Manish Sahni
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  3. Suresh Singh
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  4. Sandeep Jain
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  5. Sandeep Jasuja
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  6. Rajgovind Sharma
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  7. Sudhir Bhandari
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Contributions

A, B, C made and reviewed the manuscript and D,E, F, G reviewed the manuscript.

Corresponding author

Correspondence to Manish Sahni.

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Ethical approval was waived by the local Ethics Committee as it isa record based study.

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The authors declare no competing interests.

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Chatterjee, A., Sahni, M., Singh, S. et al. Debridement using Piezosurgical Device and Incorporation of Autologous Platelet-Rich Fibrin in Management of Stage III Medication-Related Osteonecrosis of the Jaw — A Case study and Review of Literature. Indian J Surg (2024). https://doi.org/10.1007/s12262-024-04040-x

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  • DOI: https://doi.org/10.1007/s12262-024-04040-x

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