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Identification Process and Physiological Properties of Transporters of Carboxylic Acids in Escherichia coli

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Abstract

Carboxylic acids (CAs) are important organic compounds that participate in various cellular metabolic pathways. Since maintenance of intracellular CA concentration is vital for cell growth, cells utilize transporter systems to regulate CA concentration based on the cell growth phase and extracellular environmental conditions. Metabolic engineering has received a considerable amount of attention in recent years, and although the importance of membrane transporters has been overlooked for decades, the scientific community and biotechnology companies have finally turned their attention to transporter engineering as a method to improve production efficiency in microbial cell factories. Several physiological and genetic studies conducted to date have deepened our understanding of CA transporters. In this review, we summarized the current knowledge about CA transporters in Escherichia coli, including the identification process and physiological properties of transporters, and regulation of transporter expression and activity.

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Acknowledgements

This research was supported by the Korea Institute of Marine Science & Technology Promotion (KIMST) funded by the Ministry of Ocean and Fisheries (20220258).

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  1. Seungjin Kim and Hye Kyung Lee contributed equally to this work.

Authors and Affiliations

  1. Department of Chemical Engineering, Pohang University of Science and Technology, Pohang, 37673, Korea

    Seungjin Kim & Gyoo Yeol Jung

  2. School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 37673, Korea

    Hye Kyung Lee & Gyoo Yeol Jung

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Kim, S., Lee, H.K. & Jung, G.Y. Identification Process and Physiological Properties of Transporters of Carboxylic Acids in Escherichia coli. Biotechnol Bioproc E 27, 900–908 (2022). https://doi.org/10.1007/s12257-022-0305-4

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