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Antilaminaribioside and antichitobioside antibodies in inflammatory bowel disease

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Abstract

Testing antilaminaribioside (ALCA) and antichitobioside (ACCA) antibodies in 89 Crohn’s disease (CD), 31 ulcerative colitis (UC) and 50 controls, mean values were 38.6 and 53.0 ELISA units for CD, 34.0 and 32.6 for UC, 34.5 and 36.4 for controls, respectively. There was no significant difference of ALCA values between CD and UC (p = 0.401), CD and control subjects (p = 0.698) or UC and controls (p = 0.898). ACCA were significantly higher in CD compared with UC (p = 0.011) but not with the controls (p = 0.095). No significant difference of ACCA values between UC and controls (p = 0.107) was found. ALCA and ACCA values significantly correlated in CD (r = 0.548, p < 10−4) and UC (r = 0.885, p < 10−4) but not in controls (r = 0.153, p = 0.287). The positive predictive value for CD was only 20 (ALCA) and 8 % (ACCA), the negative ones (to exclude CD) 25 (ALCA) and 86 % (ACCA). Small and/or large bowel involvement or disease type (i.e. stenosing, perforating or inflammatory) of CD did not differ in the two values. The idea that ALCA and ACCA may be useful either to differentiate between CD, UC and healthy subjects or to stratify CD was not confirmed.

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Abbreviations

ACCA:

antichitobioside antibodies

EU:

ELISA unit

ALCA:

antilaminaribioside antibodies

IBD:

inflammatory bowel disease

AMCA:

antimannobioside antibodies

pANCA:

antineutrophil cytoplasmic antibodies

ASCA:

anti-Saccharomyces cerevisiae antibodies

UC:

ulcerative colitis

CD:

Crohn’s disease

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Authors and Affiliations

  1. 2nd Department of Medicine, Charles University in Prague, 500 05, Hradec Králové, Czechia

    S. Rejchrt, M. Kopáčová, J. Cyrany, T. Douda, M. Pintér & J. Bureš

  2. Institute of Clinical Immunology and Allergology, University Teaching Hospital, Faculty of Medicine at Hradec Králové, Charles University in Prague, 500 05, Hradec Králové, Czechia

    M. Drahošová

Authors
  1. S. Rejchrt
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  2. M. Drahošová
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  3. M. Kopáčová
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  4. J. Cyrany
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  5. T. Douda
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  6. M. Pintér
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  7. J. Bureš
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Correspondence to S. Rejchrt.

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Rejchrt, S., Drahošová, M., Kopáčová, M. et al. Antilaminaribioside and antichitobioside antibodies in inflammatory bowel disease. Folia Microbiol 53, 373–376 (2008). https://doi.org/10.1007/s12223-008-0058-2

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  • DOI: https://doi.org/10.1007/s12223-008-0058-2

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